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Course: Computational Systems Biology of Cancer: Single Cell Analysis

September 23-28, 2019

Place: Institut Curie, Paris, France




Registration: no fees (the free-of-charge registration is compulsory)

Application deadline20 June, 2019

Selection results: July 1, 2019


Course objective

To improve interpretation and use of omics data that nowadays are accumulated in any biological or medical lab.  This year, the course will particularly focus on SysBio approaches for single cell data analysis. We will review current methods and tools for the analysis and interpretation of single cell data, along with concrete applications related to cancer. In particular, we will emphasize the role of single cell data research for understanding the heterogeneity of tumor.


Deciphering and modelling of biological networks involved in cancer

-Comprehensive signalling/metabolic networks and pathway databases in cancer

-Cell type-specific pathways resources

-Single cell omics data visualisation, analysis and interpretation

-Network inference from big data

-Mathematical modelling of cancer molecular mechanisms


Big data: single cell and clinical data analysis

-Inferring and analysing tumor heterogeneity from single cell data

-Prediction of response to treatment

-Single cell data for more precise patients' stratification

-Bioimage informatics as highcontent screening in single cell research

-Spatial transcriptomics in organs


Career development workshop (half a day on Saturday)

Introduction to career development opportunities in computational systems biology of cancer. Presentation of career paths and assistance of students during round tables with invited speakers, pharma representatives, scientific editing bodies.


Peter Kharchenko (Harvard Medical School, Boston, USA)

Oliver Stegle (EMBL-EBI, Hinxton, UK)

Nikolaus Rajewsky (MDC, Berlin, Germany)



Augustin Luna (Harvard Medical School, Boston, USA)

Reinhard Schneider (Luxembourg University, Luxembourg)

Heather Marlow (Institut Pasteur, Paris, France)

Luca Pinello (Harvard Medical School, Boston, USA)

Denis Thieffry (IBENS-ENS, Paris, France)

Julio Saez-Rodriguez (EMBL-EBI, Hinxton, UK)

Vassili Soumelis (INSERM, Paris, France)

Andrei Zinovyev (Institut Curie, Paris, France)

Jérome Galon (Cordeliers Research Center, Paris, France)

Estelle Duprez (CRCM, Marseille, France)

Lodewyk Wessels (National Cancer Institute, Amsterdam, The Netherlands)

Kathleen Marchal (Ghent University, Ghent, Belgium)

Ioannis Xenarios (UNIL, Lausanne, Switzerland)

Thomas Walter (Centre for Computational Biology, MINES ParisTech, Paris, France)

Jean-Philippe Vert (Google, MINES ParisTech, Paris, France)

Antoine De Weck (Novartis, Basel, Switzerland)

Andrew Teschendorff (University College London - London, UK)



Master 1, 2 and PhD students, postdoctorants from French and international universities/teams. In addition, we expect free attendees among researchers and medical doctors that interested to learn about systems biology impact into cancer research and treatment.  



Emmanuel BARILLOT Institut Curie - INSERM U900, Paris, France

Inna KUPERSTEIN Institut Curie - INSERM U900, Paris, France

Vassili SOUMELIS Institut Curie - INSERM U932, Paris, France

Denis THIEFFRY Institut de Biologie de l'École Normale Supérieure, Paris, France

Thomas WALTER Centre of Computational Biology, MINES - ParisTech, Paris, France


Scientific committee

Laurence CALZONE Institut Curie - INSERM U900, Paris, France

Tatiana POPOVA Institut Curie - INSERM U830, Paris, France

Andrei ZINOVYEV Institut Curie - INSERM U900, Paris, France