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Systems Biology Short Course, Reykjavik, Iceland - September 1-5, 2008

September 1 - 5, 2008

The University of Iceland, Reykjavik
http://systemsbiology.hi.is/

The short course is organized by Bernhard O. Palsson (Professor of Bioengineering and Medicine at UCSD and Adjunct Professor University of Iceland) and Ines Thiele (PhD Candidate in Bioinformatics at UCSD).

Registration Deadline: July 15, 2008

Bringing Genomes To Life: Reconstruction & application of genome-scale networks

The ability to experimentally generate detailed information about biological components, determine their interactions, and develop genome-wide data sets has lead to the emergence of systems biology. Systems biology is a new and rapidly growing discipline. It is widely believed to have a broad transformative potential on both basic and applied studies in the life sciences. Its core paradigm is described as a four set process:

  • reconstructed networks
  • computational models
  • physiological functions

Systems Biology is thus an interdisciplinary science that connects many diverse fields including high-throughput technologies (e.g. genomics, proteomics, etc), bioinformatics, engineering, cell biology and genetics, with mathematics and computation, in order to characterize living cells. This course will cover all these topics, with emphasis on network reconstruction and the formulation of computer models.

The course is focused on helping PhD students, current university faculty, life- science researchers, and others gain an advanced understanding of the cutting-edge field systems biology. This course will provide hands-on experience in combining experimentation and mathematical modeling with emphasis on kinetic modeling of cellular pathways. The course focuses on bacteria yeast as model systems as these are amenable to simple studies to verify predicted models. The course will be taught by world experts in the field of Systems Biology.

COURSE CONTENT
The following 4 modules will be covered during the 5 day short course:
1. High-throughput data types
    • How to generate and interpret
    • How to use for cellular reaction network Reconstruction
2. Reconstruction and model formulation
    • How to reconstruct chemically and geneticallystructured databases
    • How to represent mathematically
3. Topological and steady state analysis
    • How to analyze steady state network capabilities, properties, and topology
4. Analysis of dynamic states
    • How to determine steady state and dynamic properties of networks
    • How to use of public and commercial software packages for such analysis

Each day will be divided into a lecture part and a computational part which allows the participant to acquire hands-on experience with the taught material. Comprehensive class material will be distributed. The course is modular if students are only interested in portions of the course.

INSTRUCTORS
  • Dr. Bernhard Palsson is a Professor of Bioengineering and Adjunct Professor of Systems Biology at the University of Iceland. He has been developing in silico models of cellular processes for over 20 years. He has written a text book on Systems Biology and developed a series of courses on the subject.
  • Ines Thiele is a Senior PhD student of Bioinformatics at UCSD. She has participated in offering several short courses on Systems Biology where she covers network reconstruction technology, the COBRA toolbox, and computational methods. TBN: the names of additional lecturers will included in the final version of this flyer.
COURSE FEE
The registration fee of 200 € includes comprehensive course material. The organizers applied for Nordforsk grant which could, if accepted, cover registration fee and some travel cost of nordic participants (more information will be available mid July). 4 ECTS Credits will be given for the Systems Biology Course for course participation and successful pass of the final exam.

TIME & LOCATION
University of Iceland, Reykjavik September 1 - 5, 2008
Morning Lecture: 8.30 am - 12 am Lunch: 12 pm - 1 pm Computer Session: 1 pm - 3.30 pm Afternoon Session: 3.30 pm - 5.30 pm

REGISTRATION & CONTACT
The registration deadline is July 15, 2008. Contatct: Ines Thiele ithiele @ ucsd.edu