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Bioinformatician/Computational Biologist

Job Title: Bioinformatics Specialist I 
Job Posting ID: 3032741
Salary Plan: Full-Time, Exempt
Lab: Walker
Direct Supervisor: Bruce D. Walker, M.D.
Email Contact: David Collins (drcollins [at] mgh.harvard.edu)
Employing Hospital and Department:
Ragon Institute of MGH, MIT, and Harvard
Minimum degree and field of knowledge: Bachelor's
Years experience required: 2

Summary:
A position is open for a full-time bioinformatician at the Ragon Institute of MGH, Harvard and MIT. The candidate will perform computational analysis of data generated from HIV patient specimens. Knowledge gained from these studies will inform the design of more effective vaccines and treatments against HIV.

Job Duties: 
Under the direction of the principal investigator and collaborating bench scientists, and with guidance from other computational biologists at the Ragon Institute, the candidate will develop and implement analytical pipelines for the analysis of high-throughput assay data including single-cell and population RNA-seq, atomic-resolution protein structure data, and high-dimensional flow and mass cytometry. In addition to communicating methods and results to lab members and collaborators, the candidate will be expected to contribute to manuscript preparation. The candidate will contribute to multiple projects with the goal of improving our understanding of human immunology and enabling the development of novel HIV therapies. Specific responsibilities include the following: 
Analysis 
  • Advise bench scientists as they design experiments to produce robust data sets that are amenable to analysis and statistical testing. 
  • Communicate with collaborators to understand and develop requirements and specifications for analysis. 
  • Develop reproducible pipeline for data analysis of specific assay data (e.g., single-cell RNA-Seq) 
  • Integrate multiple data types using system approaches for generating novel biological insights 
  • Write detailed reports to be used to disseminate results to collaborators and prepare manuscripts 
Data management and high performance computing
  • Implement creative solutions for large volume data management challenges (e.g. databases) 
  • Create reusable high performance computing solutions for processing large data sets (e.g. write specific parallel code or scripts to send multiple jobs to a queue) 

Qualifications: 
Minimum Qualifications
  • Bachelor's or Master's degree with 2 or more years of demonstrated bioinformatics or computational biology experience 
  • Proficiency in R and a scripting language (Python especially preferred)
  • Familiarity with high performance computing and computing clusters
 Preferred Qualifications 
  • Prior experience with single-cell RNA-seq analysis strongly preferred
  • Familiarity with network analysis 
  • Familiarity with bioinformatic databases, such as GEO, UCSC Genome Browser, and MSigDB; and workflows such as those within Galaxy and GenePattern 
  • Experience with version control tools (preferably Git) 
Expectations
  • Demonstrate integrity, excellence, accountability, and teamwork in all interactions
  • Good oral and written communication skills
  • Ability to maintain organized, detailed, and up-to-date documentation 
  • Strong interest in human immunology and infectious disease research
Application Information: 
The position is open immediately, although the start date is flexible. Please submit a cover letter, CV, and references to David Collins
(drcollins [at ] mgh.harvard.edu). Unfortunately, due to the number of applications we receive, we may not be able to reply individually to all inquiries. All applicants must be able to come to Cambridge, MA USA for an interview.

The above job description details the major duties and qualifications of the listed position. The employee hired to this position confirms that he/she is able to perform all duties outlined. Although the specific duties and responsibilities of this position may vary slightly, the supervisor of this position will ensure that the employee hired to this position is trained and qualified to complete each task assigned. If the duties or responsibilities of this position need to change significantly, then the supervisor must submit an updated job description to the Office Manager for review.

posted 2017.01.25