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Environmental Protection Agency Cross-ORD Postdoctoral Program Mapping Toxicity Pathways for Environmental Chemicals closed

A key mission of US EPA's Office of Research and Development (ORD) is the development and implementation of robust and efficient methods to identify chemical hazards. Determining the mechanisms of action of toxic chemicals is a critical step toward improving our ability to achieve this mission.  A promising approach to this problem is to delineate toxicity pathways that are activated by chemicals. Toxicity pathways describe the key molecular level details of mechanisms of action and link chemical interactions at target sites with higher level adverse outcomes. The data that are required for pathway mapping come from assays that probe a system as it is perturbed by introduction of toxic chemicals. EPA researchers are generating large and diverse data sets that are ideal for use in mapping toxicity pathways. These include high throughput screening (HTS), high content screening (HCS) and genomics data from both in vitro and in vivo systems. A critical need is the development of robust analytical approaches that use these data sets to systematically map toxicity pathways.

EPA has an immediate opening at the postdoctoral level to develop new approaches to use HTS, HCS, genomics and whole animal toxicology data sets to map out toxicity pathways. This project will requires skills in bioinformatics (required to manage and manipulate large, multi-domain data sets and to link these with other related data); in statistics (required to mine the data sets for correlations that are indicative of true interactions); and in computational sciences (required to build the requisite software and databases). Novel tools will be tested on data being generated by mission critical EPA programs. The position is at the EPA campus in Research Triangle Park, NC, but will involve significant interactions with EPA researchers at other sites.

The ideal candidate would have experience in one or more of the areas of computational modeling, computer science, data mining and statistical analysis, combined with a background in bioinformatics, systems biology, molecular biology, cell biology, physiology or genomics. Because the position requires both the conceptual development and the implementation of this system, both biological knowledge and software development experience are critical.

Benefits: Salary range of $54,494 - $84,913; Full four-year appointments; Paid relocation to EPA duty location; Vacation and sick leave; Federal health benefits, life insurance, and retirement program; Travel to professional and scientific meetings; Flexible start date in 2008

Application Deadline: March 14, 2008

For more information, please contact
Richard Judson
judson.richard @ epa.gov
(919) 541-3085

posted 2008.02.13