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Tenure Track/Tenure Investigator Positions in Systems Immunology and Infectious Disease Modeling closed

The National Institute of Allergy and Infectious Diseases (NIAID), Division of Intramural Research (DIR) is seeking several outstanding individuals for its new Program in Systems Immunology and Infectious Disease Modeling (PSIIM).

Modern technology allows the analysis of immune responses and hostpathogen interactions at multiple levels - from intracellular signaling networks, to individual cell behavior, to the functioning of a tissue, organ, and even the whole organism. The challenge is not only to collect the large amounts of data, but also to organize it in a manner that enhances our understanding of how the immune system operates or how pathogens affect their hosts. To do this, it is necessary to develop detailed quantitative models that can be used to predict the behavior of a complex biological system. These models can help explain the mechanisms underlying physiological and pathological responses to infection or vaccination, which can then be employed to design better therapies or vaccines.

Achieving these goals requires an interdisciplinary effort and for this reason the PSIIM is organized as an integrated team of scientists and support staff. Within the PSIIM, there will be groups with expertise in the areas of computational biology, bioinformatics, proteomics, genomics, cell biology, immunology, and infectious diseases. These teams will have access to the latest technology for gene expression profiling, high content screening of RNAi libraries for the discovery of pathway components, imaging tools, genomic and proteomic analysis, cores for the genetic manipulation of animals, and a substantial computer infrastructure. They will also have access to BSL3 facilities for working with infectious agents of high priority for human health and biodefense. Although the PSIIM has been established within NIAID and has an immune / infectious disease focus, it is also expected to play a major role in fostering the growth of systems biology efforts throughout the NIH and involving diverse biomedical areas.

Current teams in the PSIIM include Immunology, Computational Biology - Modeling and Simulation, and Molecular / Cell Biology - High-throughput screening. The PSIIM is now recruiting for tenure track or tenure level team leader appointments in the following areas:

Bioinformatics / Biostatistics:
the incumbent will lead a group focused on developing and implementing computational tools and statistical methods for the analysis of genomic and proteomic data. The ideal candidate will have a strong background in statistics, mathematics, programming, and modeling biological systems as well as a strong interest in collaboration with biologists for the elucidation of biological mechanisms. The group will include expertise in software development (C++, Java, Perl, SQL etc.), knowledge of bioinformatic tools, databases and algorithms, and experience with heterogeneous computer environments (UNIX, Windows, Mac).

Proteomics: the incumbent will lead a group involved in the development and application of new methods for the determination of protein number, binding affinities, post-translational modification, and other qualitative and quantitative aspects of protein expression and behavior that are necessary for computer modeling and simulation. Tools such as mass spectrometry and microfluidic-based multiplexed binding assays are expected to be key elements in the efforts of this group. A strong background in protein biochemistry and the relevant instrumentation needed for high-throughput, high-sensitivity analysis is required.

the incumbent will be responsible for developing novel approaches to the systems-wide analysis of such issues as transcription factor and epigenetic control of gene expression, the effects of allelic polymorphism on gene expression and function, quantitative measurement of gene expression, and the role of non-coding regions and transcripts such as miRNAs in regulating gene/gene product expression patterns.

Knowledge of modern methods in high-throughput analysis of gene transcription, transcription factor binding site identification, analysis of epigenetic modifications, and analysis of gene regulatory circuits is required; bioinformatics experience is desirable. These positions and the research activities they conduct are fully funded by the intramural research program of NIAID. Each team leader is expected to build a working group consisting of postdoctoral fellows, students, technicians, and staff scientists. The team leaders will work with the Program Director to help set the goals for the PSIIM and to determine how best to reach these goals as an integrated group. To ensure appropriate career trajectories for those joining the PSIIM team effort, the NIH has modified its tenure policies to take specific account of contributions made in such a team science setting. Applicants should be seeking a difficult
challenge in which creativity, technical expertise, and a strong desire to achieve in a team setting will be critical for success.

Interested candidates may contact Dr. Ronald Germain, Program Director, PSIIM, DIR, NIAID at (301) 496-1904 or email (rgermain @ niaid.nih.gov) for additional information about these positions.

To apply, submit your curriculum vitae, bibliography, and a detailed statement of how your expertise can contribute to the success of the PSIIM program, to Wanda Jackson at NIAID.DIR.Search @ niaid.nih.gov.
In addition, three letters of reference must be sent directly from your three referees to Dr. Robert Hohman, Chair, NIAID Search Committee, c/o Wanda Jackson at NIAID.DIR.Search @ niaid.nih.gov or 10 Center Drive, MSC 1356, Building 10, Room 4A22, Bethesda, Maryland 20892-1356.
Email is preferred. Completed applications MUST be received by Friday, May 23rd.
Please refer to ad #019 for bioinformatics/biostatistics, #020 for proteomics, and #021 for genomics on all correspondence.
Further information regarding the DIR laboratories is available at:http://www3.niaid.nih.gov/about/organization/dir/default.htm and information on working at NIAID is available on our website at: http://healthresearch.niaid.nih.gov

For more information about the NIAID systems biology program, please visit http://www.nih.gov/catalyst/2006/06.09.01/page1.html

posted 2008.04.14