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Intership/Student project: PARTICLE SIMULATION OF ANTIBODY - TARGET INTERACTION open

Description:

To design a new generation of monoclonal antibody (mAb) drugs we are applying novel modeling and simulation approaches. An accurate modeling of antibody-target interaction is critical for reliable predictions which directly feed into the drug development process. The current project aims to study the fundamentals of antibody-target interaction. Commonly this system is modeled with ordinary differential equations. For a one-to-one partner binding system this model is an accurate description. However, for the case of cell surface targets or where the target has multiple binding sites it is unclear how the interactions must be modeled in an ODE framework. The idea is to develop a particle simulation tool that can be used to study the fundamentals of antibody dynamics and derive the appropriate ODEs. This study is  also expected to impact the design of more complex biological constructs and is therefore at the leading edge of modeling and simulation in drug development.
Contact:
Prof. J. H. Walther (jhw @ mek.dtu.dk)
Technical University of Denmark
Fluid Mechanics Section, Dept. of Mech. Engng.
Building 403, DK-2800 Kgs. Lyngby, Denmark  
Phone : (+45) 4525 4327
Fax : (+45) 4588 4325
Web : http://www.mek.dtu.dk

posted 2008.05.07