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2011

Doctoral Candidate (PhD student) in Systems Biochemistry closed

(m/f)Application End :  Friday November 25 2011
The University of
Luxembourg is looking for the newly established Luxembourg Centre for Systems Biomedicine (LCSB) for a Doctoral Candidate (PhD student) in Systems Biochemistry (m/f)

Ref. I1C-DIR-COM-11ICOO
Fixed-term contract 3 years, 40h/week renewable
once Student and Employee status
The PhD student will be a member of the
highly interdisciplinary research centre, integrating experimental biological and computational biology approaches in order to develop the foundation of a future predicitive, preventive and personalised medicine.

Area:
Biochemistry/Medical Biochemistry/Neurochemistry.

Mission:

Experimental determination of metabolic flux and concentration is a critical tool for developing understanding of the physiological state of a cell. Using isotopically labeled substrates with different
labeling patterns, experimental techniques are used to measure the mass isotopomer distributions of select metabolites. Estimation of metabolic flux is by integration of mass isotopomer distributions with
an isotopomer (isotope isomer) mapping model, that traces the path of each isotopomer through a metabolic network. Recently an algorithm for automated generation of draft genome-scale isotopomer mapping models has been develope. The latest reconstruction of human metabolism (Recon 2.0) is a stoichiometric model of a generic human cell. It is necessary to tailor Recon 2.0 to represent the metabolic capabilities of a particular cell type of interest. Extensive manual curation of neurochemical experimental data is necessary to tailor Recon 2.0 to accurately represent the metabolism of a normal neuron. A tailored stoichiometric model of a dopaminergic neuron, that also represents atom transitions for each reaction, would be an invaluable resource for estimation of metabolic flux and concentration in cultured dopaminergic cell lines.

Tasks:

To address the aforementioned challenges, the PhD project objectives are:
Reconstruction of a tailored stoichiometric model of a normal
dopaminergic neuron by literature review.

Manual curation of an existing algorithmically created draft isotopomer mapping model of Recon 2.0 to retain only biochemically realistic atom transitions.Biological interpretation of whole cell metabolic flux and concentration data in normal and diseased dopaminergic neuronal cells toward a deeper understanding of Parkinsonism pathogenesis.

Profile:

A broad and deep knowledge of metabolic biochemistry e.g. M.Sc. level Medical Biochemist, Biochemist, Neurochemist.Excellent English writing and speaking skills.

Offer:

Contribution to an international, interdisciplinary project: Dr. Karsten Hiller, LCSB, Dr. Ronan Fleming, Center for Systems Biology, University of Iceland (CSBUI).
International interdisciplinary
training: In the first year, a 6 month training period in metabolic networkreconstruction & modeling at the CSBUI.
The University of
Luxembourg offers competitive salaries and is an equal opportunity employer.

Application:

All applications (in English) should contain the following documents:
A detailed curriculum vitae
Cover letter mentioning the reference
number
List of publications
Description of past research experience and
future interests
Name and addresses of three referees
Please send your
electronic applications until the 23rd Dec 2011 to the following address:   katrin.effenberger at uni.lu

posted 2011.11.24

two assistant professors in systems biology open

University of Colorado Denver  Department of Integrative Biology
  • Molecular Biologist [Job Posting #815425]
  • Geneticist [Job Posting #815436]
  • Systems Biologist [Job Posting #815434]
     

The Department of Integrative Biology at the University of Colorado Denver is seeking qualified applicants at the rank of assistant professor for the positions of 1) Molecular Biologist, 2) Geneticist, and 3) Systems Biologist. We seek candidates with active research programs, successful funding records, experience teaching and mentoring students, and innovative approaches to research problems.  

The University of Colorado Denver is an urban research university comprised of the Denver Campus and the Anschutz Medical Campus.  It is a recently consolidated university within the University of Colorado system.  The consolidated university confers more graduate degrees each year than any other higher education institution in Colorado, offers over 130 degree programs in 13 schools and colleges, and brings in nearly $400 million annually in sponsored research.

The Denver Campus is located on Auraria Campus next to a vibrant downtown commercial and cultural district, three major professional sports venues, the Denver Convention Center, and city and state government offices.  Student housing is available adjacent to campus. The Denver Campus alone has an enrollment of over 15,000 students and a highly diverse student population.

The Biology Major in the Department of Integrative Biology emphasizes basic knowledge in biology ranging from cell and molecular biology to ecology and evolution, as well as the development of skill sets in the scientific method, critical thinking, and technical writing.  The Denver Campus Health Professions Advising office is based within Integrative Biology. The department is on a growth trajectory; it currently has 13 tenured or tenure-track faculty and 6 full-time instructors.  The department has an active Masters program, with a joint doctoral degree program with the Anschutz Medical Campus under development.  

  

1) Molecular Biologist [Job Posting #815425]

Job responsibilities:

The successful candidate will establish an independent, externally funded research program related to the field of molecular biology.  Teaching responsibilities include undergraduate and graduate level courses in molecular biology and other areas of the candidate's expertise.  The successful candidate will mentor undergraduate and graduate students.

Required qualifications:

A Ph.D. in the biological sciences or related field and a strong record of publishing in molecular biology, or a related field, are required.  We encourage scientists with a broad range of research questions and systems to apply.  The candidate should be self-motivated and able to collaborate with faculty members in Integrative Biology and other UCD programs, and possibly scientists at the Anschutz Medical Campus.

Preferred qualifications:

Postdoctoral research, experience applying to national funding agencies, and experience with mentoring students and teaching are highly desirable qualifications.

 

2) Geneticist [Job Posting #815436]

Job responsibilities: 

The successful candidate will establish an independent, externally funded research program in genetics.  The Department is particularly interested in the use of molecular approaches in the candidate's research program.  Teaching responsibilities include an undergraduate course in general genetics and upper division or graduate level courses in population and evolutionary genetics or in the candidate's area of expertise.  The successful candidate will mentor undergraduate and graduate students.

Required qualifications:

A Ph.D. in the biological sciences or related field and a strong record of publishing in genetics or a related field are required.  We encourage scientists with a broad range of research questions and systems to apply.  Research areas could include plant, animal, or microbial systems and should complement, but are not limited to, current faculty interests.  The candidate should be self-motivated and able to collaborate with faculty members in Integrative Biology and other UCD programs.

Preferred qualifications:

Postdoctoral research, experience applying to national funding agencies, and experience with mentoring students and teaching are highly desirable qualifications.

3) Systems Biology [Job Posting #815434]

Job responsibilities: 

The successful candidate will establish independent, externally funded research programs related to systems biology.  Teaching responsibilities include undergraduate and graduate courses in the candidates' areas of expertise; the successful candidate will instruct courses directly related to the proposed doctoral program and develop new courses related to their research areas.  The candidate will be expected to mentor undergraduate and graduate students.     

Required qualifications:

A Ph.D. in the biological sciences or related field and a strong record of publishing in the area of systems biology, or a related field are required.  We are searching broadly in systems biology, and research areas of the applicant pool should span all levels of biological organization from the genome to ecology and evolution.  All study systems will be considered and should complement, but are not limited to, current faculty interests.  The candidate should be self-motivated and able to collaborate with faculty members in the Department of Integrative Biology and other UCD programs, including those at the Anschutz Medical Campus.

Preferred qualifications:

Candidates should have experience in computational methods and modeling necessary to study how systems operate.  Experience with experimental approaches to research is also preferred. Additional highly desirable qualifications include a demonstrated record of funding and applying to national funding agencies, a record of mentoring students, and teaching experience. 



Applications are submitted electronically at www.jobsatcu.com

Review of applications will begin as they are received, and will continue until the position is filled.

 

 
 

 

 


For all positions, salary is commensurate with skills and experience.  The University of Colorado offers a full benefits package.  Information on University benefits programs and eligibility are available at http://www.cu.edu/pbs/

Applications must include:

1.    A letter of introduction, which addresses the position requirements and summarizes the qualifications of the applicant.

2.    Full Curriculum Vitae.

3.    Research Statement, describing research interests.

4.    Teaching Statement, describing philosophy and courses taught and history of mentoring graduate and undergraduate students.

5.    The names, addresses, and daytime phone numbers for four professional references.

Questions regarding the Molecular Biologist and Genetics positions should be directed to Dr. Brad Stith: brad.stith@ucdenver.edu.

Questions regarding the positions in Systems Biology should be directed to Dr. Mike Greene: michael.greene@ucdenver.edu.

UCD is dedicating to ensuring a safe and secure environment for our faculty, staff, and students.  To achieve that goal, we conduct background investigations for all prospective employees.

The University of Colorado is committed to diversity and equality in education and employment.

 

 

posted 2011.11.07

Junior Researchers / Post Doctoral Researchers at COSBI open

The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI) is a dynamic, multicultural and multidisciplinary research center based in Northern Italy where scientists collaborate with the aim of improving the understanding of biological processes using programming languages. Along with advanced research programs, COSBI activities include many collaborations worldwide, and the development of solutions to academic and industrial partners.

 

COSBI is currently looking for highly motivated and experienced Junior Researchers / Post Doctoral Researchers: 

Junior Researcher in Ad-Hoc Language Design and Implementation

Junior Researcher in Hybrid Symulation

Junior Researcher in Computational Systems Ecology

Junior Researcher in Molecular Nutrition

Junior Researcher in Static Analysis

Junior Researcher in Bioinformatics, Data Inference and Manipulation

Junior Researcher in the field of Compilation of concurrent languages on parallel architectures

 

The positions listed above require a PhD in bioinformatics, computational biology, computer science or molecular biology and some years of research experience in the specific field.

An extensive description of our Institute and of our vacancies currently available at COSBI are given at www.cosbi.eu/index.php/people/careers.

Learn more at www.cosbi.eu!

posted 2011.10.18

Assistant Professor in Systems Biology open

This job listing is available here: http://jobs.ucmerced.edu/n/academic/position.jsf?positionId=3523

Assistant Professor in Systems Biology
Position Title:         Assistant Professor
Position Code:          ASNS3523A
Status:         Open


Description:            The University of California, Merced is a dynamic new university campus in Merced, California, which opened in September 2005 as the tenth campus of the University of California and the first American research university in the 21st century. In keeping with the mission of the University to provide teaching, research and public service of the highest quality, UC Merced offers research-centered and student-oriented educational opportunities at the undergraduate, master's and doctoral levels through three academic schools: Engineering, Natural Sciences and Social Sciences/Humanities/Arts.
The School of Natural Sciences at the University of California, Merced announces a tenure-track faculty position at the level of Assistant Professor in the area of systems biology. Systems biology is a research approach that uses high-throughput comprehensive datasets and integrates multiple types of analysis to relate the overall function of an organism, cell, organelle, or regulatory pathway to the underlying physiological, biochemical or biophysical processes, with an ultimate goal of a predictive understanding of the system's behavior. Applicants of special relevance to research emphases at UC Merced include gene expression mechanisms, RNA biology in development and regeneration, mechanisms of cell fate decisions, complex diseases such as diabetes or inflammatory disorders, and microbial systems. The successful candidate will have the opportunity to participate in the Health Sciences Research Institute at UC Merced and with UC campuses and UC-affiliated national laboratories.
The University of California at Merced is an affirmative action/equal opportunity employer with a strong institutional commitment to the achievement of diversity among its faculty, staff, and students. The University is supportive of dual career couples.

Qualifications:         Applicants must have a Ph.D. in biology, biochemistry, biophysics or other relevant field, and a record of research, publication, and teaching commensurate with a faculty appointment at the UC at the assistant professor level. Candidates should demonstrate their potential to establish an externally-funded research program in systems biology, have a demonstrated record of collaboration, and be able to teach biology effectively at both undergraduate and graduate levels.


Salary:         Salary is negotiable, based on University of California payscale.
To Apply: http://jobs.ucmerced.edu/n/user/academic/application/instruct.jsf?positionId=3523
Closing Date:           12/05/2011

posted 2011.10.14

PhD Systems/Computational Biology (open) open

In the frame of multiple systems biological projects funded by the German Ministry for Education and Research (BMBF: MEDSYS, FORSYS, Virtual Liver, GerontoSys) the Hamamatsu TIGA (Tissue Imaging and Analysis) Center of the University Hospital Heidelberg is looking for a

PhD Systems Biology / Computational Biology: Biological Networks & Simulation.

 

You will work in close collaboration with multiple research groups of the University Hospital (e.g. National Center for Tumor Diseases), German Cancer Research Center (DKFZ) on multiple clinically relevant questions. Goal of the work is the development of algorithms for building logical and qualitative networks from existing biological databases of regulatory interactions, which will be used for interpreting experimental high-throughput data from our own lab or partners. Logical or qualitative reasoning and simulation approaches will be used for deriving predictions from the networks. Together with the project partners and other team members you will structure the projects, implement apply novel algorithms and publish the results.

 

Environment: The TIGA Center is a cooperative unit with multiple partners and is hosted in the internationally leading systems biological center BIOQUANT at the University Heidelberg.  You will work in close collaboration with multiple research groups of the University Hospital (e.g. National Center for Tumor Diseases), German Cancer Research Center (DKFZ) and other groups. The open position therefore offers an exciting environment for interdisciplinary research with state-of-the art modern systems biology. We offer a friendly but dynamic working atmosphere where you have the unique opportunity to work daily with experimentalists in our own and related groups to optimally continue your scientific career.

 

Position: We are looking for a committed and integrating personality who values this special environment and would like to contribute his or her outstanding experience. Your background should be from computer science, computational biology or a related discipline. Experience in software developing (for example C++, JAVA, Python or Perl) is essential. Experience with graph algorithms, mathematical and computer modeling of biological systems will be appreciated. You will closely interact with computer scientists and biologists, therefore you should be able to communicate in English in daily routine and demonstrate interest in contributing to scientific publications.

 

Your application should contain

a) a detailed CV

b) a description of previous scientific experiences

c) your interests and method spectrum

d) two possible contacts for references

 

Salary is according to TV-L 13/2 (50%).

The University of Heidelberg is an equal opportunity employer.

 

Please send your application exclusively by e-mail to: tiga.jobs @ googlemail.com

PD Dr. Niels Grabe,

Institute for Medical Biometry and Informatics,

University Hospital Heidelberg.

posted 2011.10.05

Postdoc Systems/Computational Biology (open) open

In the frame of multiple systems biological projects funded by the German Ministry for Education and Research (BMBF: MEDSYS, FORSYS, Virtual Liver, GerontoSys) the Hamamatsu TIGA (Tissue Imaging and Analysis) Center of the University Hospital Heidelberg is looking for a 

PostDoc Systems Biology / Computational Biology: Biological Networks & Simulation.

 

You will work in close collaboration with multiple research groups of the University Hospital (e.g. National Center for Tumor Diseases), German Cancer Research Center (DKFZ) on multiple clinically relevant questions. Goal of the work is the development of algorithms for building logical and qualitative networks from existing biological databases of regulatory interactions, which will be used for interpreting experimental high-throughput data from our own lab or partners. Logical or qualitative reasoning and simulation approaches will be used for deriving predictions from the networks. Together with the project partners and other team members you will structure the projects, implement apply novel algorithms and publish the results.

 

Environment: The TIGA Center is a cooperative unit with multiple partners and is hosted in the internationally leading systems biological center BIOQUANT at the University Heidelberg.  You will work in close collaboration with multiple research groups of the University Hospital (e.g. National Center for Tumor Diseases), German Cancer Research Center (DKFZ) and other groups. The open position therefore offers an exciting environment for interdisciplinary research with state-of-the art modern systems biology. We offer a friendly but dynamic working atmosphere where you have the unique opportunity to work daily with experimentalists in our own and related groups to optimally continue your scientific career.

 

Position: We are looking for a committed and integrating personality who values this special environment and would like to contribute his or her outstanding experience. Your background should be from computer science, computational biology or a related discipline. Experience in software developing (for example C++, JAVA, Python or Perl) is essential. Experience with graph algorithms, mathematical and computer modeling of biological systems will be appreciated. You will closely interact with computer scientists and biologists, therefore you should be able to communicate in English in daily routine and demonstrate interest in contributing to scientific publications.

 

Your application should contain

a) a detailed CV

b) a description of previous scientific experiences

c) your interests and method spectrum

d) two possible contacts for references

 

The position is currently limited for 2 years.

Salary is according to TV-L 13.

The University of Heidelberg is an equal opportunity employer.

 

Please send your application exclusively by e-mail to: tiga.jobs @ googlemail.com

PD Dr. Niels Grabe,

Institute for Medical Biometry and Informatics,

University Hospital Heidelberg.

posted 2011.10.05

Postdoctoral Position in Computational/Systems Biology open

A Network Biology Approach to Understanding the Impact of Genetic Variation on Susceptibility to Bovine Infectious Diseases.

A two-year Science Foundation Ireland funded postdoctoral position is currently available in the newly established Teagasc (Irish Agriculture & Food Development Authority), Animal & Bioscience Department, in Co. Meath in Ireland.

The successful candidate will utilise a network/systems biology approach to investigate the impact of genetic variation on molecular interaction networks regulating host susceptibility to infectious disease in cattle and other organisms (human/mouse). In particular, this position will seek to identify potentially new candidate genes which influence susceptibility to bovine tuberculosis. Tuberculosis is a devastating disease of humans and animals. Bovine tuberculosis, caused by Mycobacterium bovis, is a major zoonotic pathogen and causes losses to global agriculture of approx. €2.2 billion per annum.

This project is a computational biology project and as such the applicant should have a PhD in computational biology/bioinformatics, along with strong programming skills (Perl, C, Java) and should be very familiar with working in a Linux and HPC environment. Database management skills (e.g. MySQL) would also be useful. Demonstrated experience in network/systems biology would be a strong asset, as would knowledge/interest in immunology/infectious disease research. Experience with interpreting large-scale genotype data and genome-wide association data is also sought.

This is a collaborative project between Dr. David Lynn's group at the Teagasc Animal & Bioscience Department and Prof. Dan Bradley's group at the Smurfit Institute of Genetics, Trinity College Dublin. The Animal & Bioscience Department is located in brand-new state-of-the-art facilities in the rolling Irish countryside of Ireland's Heritage Capital, County Meath, and yet is within easy commuting distance of Dublin City, one of the most vibrant cities in Europe.

Salary
The successful candidate will be appointed in accordance with SFI's post-doctorate researcher pay-scale with starting salary of €41,808 per annum. The current salary scale is €41,808 to €51,228.

Starting pay will be at the minimum of the scale per Government Circular E100/8/82. Exceptional circumstances may apply for candidates with current or previous service in the public sector (including Teagasc). Remuneration may be adjusted from time to time in line with Government Policy.

How to Apply
If you wish to apply for this position please log on to the following link, http://www.publicjobs.ie/publicjobs/en/star/goToJobDetails.do?id=1968.

Please ensure to include and attach a covering letter, a Curriculum Vitae, and contact details for three referees along with your completed application form and submit online to Public Appointments.

Candidates must register their details through www.publicjobs.ie prior to applying. Application forms cannot be accepted after the closing date.

The completed application documents must be forwarded so as to reach the Public Appointments Service not later than midnight, 10th October 2011.

If you are interested in this position and would like further information please email Dr. David Lynn, at david.lynn @ teagasc.ie.

posted 2011.10.05

OPEN POSITIONS IN COMPUTATIONAL SYSTEMS BIOLOGY open

Two PhD Marie-Curie positions available to start in early 2012.

Location: IIM-CSIC, Vigo, Spain
Duration: 36 months
Conditions: Marie Curie Early Stage Researcher positions

For detailed information about requirements and how to apply, please check:
http://www.iim.csic.es/~julio/positions.html

Julio R. Banga
Email: julio at iim.csic.es

posted 2011.09.29

two PhD positions in systems biology of evolution and development open

Helsinki University
Institute of Biotechnology
Helsinki evo-devo research community
Salazar-Ciudad group

We are looking for two students, preferably biologists, to start two grants for two PhDs in systems biology and/or evo-devo about:

        -Gene network simulations of pattern formation, morphogenesis and
        morphological evolution of mammalian organs.

                         or/and

        -Variational phenomics, 3D morphometrics, development and evolution

 One of the current challenges of evolutionary biology is to understand how genetic variation leads to specific morphological variation (the genotype-phenotype map) and how that process affects the direction of morphological change in evolution. Our group is devoted to address this question by using gene network models and empirical analysis of developmental and  variational data.

Programming skills or a willingness to acquire them are required.

 The grants are provided through the Finnish academy of sciences.
 One of the positions is between Isaac Salazar-Ciudad´s Group and Jukka Jernvall's group and the other is in Isaac Salazar-Ciudad's group.
 The exact topic of the theses would be discussed in detail after an interview.

 For an outline of the groups' research:
 http://www.biocenter.helsinki.fi/bi/evodevo/group_isaac.shtml
 http://www.biocenter.helsinki.fi/bi/evodevo/index.shtml

 For further inquiries:
 isaac.salazar at uab.cat

 Article example:

Salazar-Ciudad I, Jernvall J.A computational model of teeth and the developmental origins of morphological variation. Nature. 2010 Mar 25;464(7288):583-6.

posted 2011.09.27

Postdoctoral Position in Computational/Systems Biology open

A Network Biology Approach to Understanding the Impact of Genetic Variation on Susceptibility to Bovine Infectious Diseases.

A two-year Science Foundation Ireland funded postdoctoral position is currently available in the newly established Teagasc (Irish Agriculture & Food Development Authority), Animal & Bioscience Department, in Co. Meath in Ireland.

The successful candidate will utilise a network/systems biology approach to investigate the impact of genetic variation on molecular interaction networks regulating host susceptibility to infectious disease in cattle and other organisms (human/mouse). In particular, this position will seek to identify potentially new candidate genes which influence susceptibility to bovine tuberculosis. Tuberculosis is a devastating disease of humans and animals. Bovine tuberculosis, caused by Mycobacterium bovis, is a major zoonotic pathogen and causes losses to global agriculture of approx. €2.2 billion per annum.

This project is a computational biology project and as such the applicant should have a PhD in computational biology/bioinformatics, along with strong programming skills (Perl, C, Java) and should be very familiar with working in a Linux and HPC environment. Database management skills (e.g. MySQL) would also be useful. Demonstrated experience in network/systems biology would be a strong asset, as would knowledge/interest in immunology/infectious disease research. Experience with interpreting large-scale genotype data and genome-wide association data is also sought.

This is a collaborative project between Dr. David Lynn's group at the Teagasc Animal & Bioscience Department and Prof. Dan Bradley's group at the Smurfit Institute of Genetics, Trinity College Dublin. The Animal & Bioscience Department is located in brand-new state-of-the-art facilities in the rolling Irish countryside of Ireland's Heritage Capital, County Meath, and yet is within easy commuting distance of Dublin City, one of the most vibrant cities in Europe.

Salary
The successful candidate will be appointed in accordance with SFI's post-doctorate researcher pay-scale with 
starting salary of €41,808 per annum. The current salary scale is €41,808 to €51,228.

Starting pay will be at the minimum of the scale per Government Circular E100/8/82. Exceptional circumstances may apply for candidates with current or previous service in the public sector (including Teagasc). Remuneration may be adjusted from time to time in line with Government Policy.

How to Apply
If you wish to apply for this position please log on to the following link, http://www.publicjobs.ie/publicjobs/en/star/goToJobDetails.do?id=1968.

Please ensure to include and attach a covering letter, a Curriculum Vitae, and contact details for three referees along with your completed application form and submit online to Public Appointments.

Candidates must register their details through www.publicjobs.ie prior to applying. Application forms cannot be accepted after the closing date.

The completed application documents must be forwarded so as to reach the Public Appointments Service not later than midnight, 10th October 2011.

If you are interested in this position and would like further information please email Dr. David Lynn, at david.lynn at teagasc.ie.

posted 2011.09.27

SYSTEMS BIOLOGIST: TT assistant faculty position open

SYSTEMS BIOLOGIST

Loyola University Chicago (LUC), College of Arts and Sciences, Department of Biology, invites applications for a full-time tenure-track position in Systems Biology at the rank of Assistant Professor, beginning August, 2012. For an overview of the department visit www.luc.edu/biology. Candidates must have a Ph.D. and post-doctoral experience, and will be expected to establish a vigorous, externally-funded research program involving undergraduates and M.S. students. Preference will be given to candidates with expertise in systems biology who use bioinformatics approaches. Teaching responsibilities will include Cell Biology, Developmental Biology and an advanced course in the candidate's area of specialization that can contribute to the Bioinformatics program (www.luc.edu/bioinformatics). Candidates should complete the online application in full at www.careers.luc.edu with cover letter, CV, research plan, teaching philosophy statement, and names/contact information for 3
references. Review of applications will begin November 1, 2011, and continue until the position is filled.
Inquiries about the position can be sent to: Systems Biology Search Committee, Department of Biology, Loyola University Chicago, 1032 West Sheridan Road, Chicago, IL 60660. Loyola University Chicago is an Equal Opportunity/Affirmative Action employer with a strong commitment to diversifying its faculty.
Applications from women and minority candidates are especially encouraged. For information about LUC visit www.luc.edu.

posted 2011.09.27

Postdoctoral Researcher Positions on the Molecular Basis of Persister Cell Formation in Camplyobacter open

This post will be part of a multidisciplinary project that aims to decipher the molecular mechanisms underpinning the obsrvation of persister cells in Camplyobacter jejuni (Cj). The hired candidate will focus on the system dynamics analysis and in silico evolution of molecular systems that can underlie persister cell formation and will also analyse the interaction between signalling and metabolism in the persister phenotype. These theoretical analyses will be performed in conjunction with experimental and bioinformatics work, which will focus on the characterisation of the persister phenotype. 

Further information and application details are available here;
https://jobs.exeter.ac.uk/hrpr_webrecruitment/wrd/run/ETREC107GF.open?VACANCY_ID=5074784DIG&WVID=3817591jNg&LANG=USA

posted 2011.09.09

Research Fellow (postdoc) position open

Research Fellow (postdoc) position

 

Job description:

 

The laboratory of Dr. Jean-Francois Rual in the Department of Pathology at University of Michigan is looking for a highly motivated individual with exceptional organizational skills and strong background in basic molecular and cell biology techniques to join our team as a Research Fellow. Our research interests lie in the field of systems biology and the use of proteomic approaches to study cellular networks. We focus on the systematic analysis of protein interactions in biological systems and their relationship to human disease, with particular interest in the cancer-related Notch pathway. The Rual laboratory uses biochemical, molecular, cell biological, and genetic means in high-throughput settings to address these questions. The successful candidate will have the opportunity to participate in research projects in a collaborative and interdisciplinary team environment.

 

Responsibilities:

 

Under the guidance of the PI, the Research Fellow will lead a research project related to the characterization of the Notch molecular network across metazoans by combining the use of the yeast two-hybrid system (Y2H) with co-affinity purification followed by mass spectrometry analysis (coAP-MS). The fellow will participate in project planning, data generation, interpretation and evaluation and communication of results. She/he will also be expected to acquire manuscript and grant writing skills and participate in seminars, lectures, poster sessions and presentations at national meetings. The fellow may be required to supervise junior lab members, develop new methods and protocols for research and assist with the development of other projects in the lab. While the foundations of the lab are being developped, the candidate will be expected to take responsibility for a wide range of experimental and non-exprimental activities which will contribute greatly to her/his training and development into a successful independent investigator.

 

Required qualifications:

 

Requirements for this position include a PhD or MD/PhD in the biological sciences and the ability to master a variety of cellular and molecular biology techniques. The successful candidate must have strong interpersonal, communication and organizational skills and be a committed team player.

 

Application:

Completed applications for these positions will include: (1) a CV; (2) a cover letter describing your specific interest in this position and relevant qualifications and skills; and (3) the names and contact information of three or more references. All files should be sent as PDF files, electronically to: jrual at umich.edu and cniemiec at med.umich.edu, subject line "Rual Laboratory Research Fellow position".

posted 2011.08.05

Postdoc Position in Medical Systems Biology open

The Division of Theoretical Bioinformatics (Kst. B080) , The German Cancer Research
Center is seeking a Postdoc Position in Medical Systems Biology
(Ref-No. 101/2011)

Description:

Within our division, we are looking for an experienced Postdoc to work in a project within the BMBF-funded project AGENET (GerontoSys II), which studies molecular mechanisms of aging. The highly interdisciplinary project will involve close interaction with experimental partners, statistical analysis of high-throughput data, and development and curation of ODE-based dynamic gene expression models. The project will aim at combining high-throughput func-tional genomics data with detailed mechanistic modeling at different time scales.

Your profile:
Candidates should hold an excellent PhD in physics, applied mathematics, engineering or biological sciences and have profound expertise in interdis-ciplinary research, systems biology, biophysics and/or nonlinear dynamics. Experienced applicants will have the opportunity to lead an established systems biology team together with Prof. Eils including the supervision of Postdocs and PhD-students. Applications should include cover letter, CV, copies of diploma/PhD certificates, details of previous research experience, two references with email addresses, research interests (~1 page).

Duration: The position is limited for 3 years.

Compensation/Financing: E13/E14, Grant funding

Contact: Dr. Jan Eufinger, phone 06221 42-3623, j.eufinger@dkfz.de

Application Deadline: August 15, 2011

The position can in principle be part-time.

The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference. Please send your application to

Deutsches
Krebsforschungszentrum
Personalabteilung
Im Neuenheimer Feld 280
D-69120 Heidelberg

Or apply preferably online: www.dkfz.de

posted 2011.07.13

Two Postdoctoral positions in Bacterial Evolutionary Genomics University of Basel, Switzerland open

We are seeking two independent, highly motivated postdoctoral candidates to begin work in our group. We have a new project focused on quantitatively characterizing how bacterial phenotypes evolve over short evolutionary time scales, with the aim of relating phenotypic changes to underlying genomic changes. We will use high-throughput phenotypic and genomic characterization of a large number of environmental isolates of bacteria. An integral part of the project will involve computational analysis to relate the observed phenotypic changes to genomic changes. However, the direction that this projects proceeds in is dependent on the interests of the candidates and for this reason, candidates who display the ability and desire to work independently will be given priority.
Both positions require strong mathematical or computational skills; at least one position will also require a solid background in experimental biology (preferably microbiology). In addition, familiarity with phylogenetic and comparative methods would be highly advantageous.

The research group is headed by Prof. Erik van Nimwegen and is in the Computational and Systems Biology Program at the Biozentrum, University of Basel. Dr. Olin Silander heads the experimental work in the group. The research interests of our group concern the evolution of genomes and the function and evolution of molecular interaction networks, including transcriptional regulatory networks and signaling networks. Our group is highly interdisciplinary, with members whose backgrounds range from molecular biology to theoretical physics.

The candidates should have a good knowledge of English. German is helpful but not necessary. The salary is generous and is set according to the guidelines of the Swiss National Science Foundation; the start date will by mutual arrangement. Each position has funding for up to three years.

Basel is a very international city and a center of life science research, with over 900 companies in the area, including Novartis and Roche. Several other academic institutions are also in the city, including the Swiss Tropical Institute, the Frederich Miescher Institute, and the ETH Zurich Biosystems Science and Engineering Department. The city is less than 5km from both France and Germany and less then two hours from the Swiss Alps.

To apply, please send a single pdf containing your application letter, CV and the names of two or three references to
olin.silander @ unibas.ch
Review of applications will begin immediately, and the start date will be by mutual agreement.

posted 2011.05.10

Medical Research Associate, Systems Biology open


· Full -time & Part -time opportunities
· Lighthouse Laboratories, Western Australia
· Salary (Full-time) $70K - $90K PA (AUS) - Pro rata Part-time

Lighthouse was established in Feb 2003 as a not for profit charitable research entity with a mission thus summarised: Medical research to stop the human hurt without hurting animals.

Located in Western Australia Lighthouse is still emerging as a research body to encompass diverse research themes in an interdisciplinary approach. Child cancer, in particular neuroblastoma, represents the founding research theme. Both autonomous and collaborative research is pursued on a national and international level.

This position represents a pivotal role to assist the scientific director with the development and implementation of an inaugural systems biology research program. As such, the role requires more than an essential relevant PhD qualification and experience; the ideal candidate(s) will have a desirable flair for enterprise to pioneer the application of Systems Biology principles to areas of child cancer biology. With a policy not to use animals in human research, the program intention centres on the integration of pre-gathered data from clinical sources and human tissue samples that will be both evaluated (bio-statistics/ informatics) and incorporated into models (mathematically/computationally) at a basic and translational level.

For further information visit www.lighthouselabs.org.au www.lighthouseIRC.org.au and/or see contact details below for a position description.

Contact: Mr Graeme Tucker, Executive Chairman & Scientific Director of Lighthouse Laboratories. +61 8 9250 4330 gtucker @ lighthouselabs.org.au

Closing date: May 15, 2011

Anticipated commencement date: Between June 22 -29, 2011
Application:
Lighthouse is endorsed as a 457 work visa sponsor and as such encourages overseas applicants. Please email your resume, details of two referees (one being you most recent employer/supervisor) and a covering letter in PDF format to gtucker @ lighthouselabs.org.au

posted 2011.05.09

Postdoctoral position. Columbia University, New York open

A postdoctoral position is available for a highly motivated individual in an interdisciplinary team at Columbia University, in New York, US. The main project will be associated to the development and implementation of techniques to analyze genomic alterations in cancers using High Throughput Sequencing Technologies. The project is a collaboration between different laboratories in the US and Europe.

Applicants must have a PhD degree in any quantitative science (preferably computer science, physics, astrophysics, computational biology, statistics or mathematics). Expertise in High Throughput Sequencing Technologies is not expected but highly valued. The candidate should have a working knowledge of programming, statistical analysis with demonstrated experience in problem solving. Excellent organizational and communication skills are a must.

Interested applicants should submit a letter of interest, CV, and name and contact information of three references by e-mail to *rabadan @ dbmi.columbia.edu*. Deadline: 20th May 2011.

Columbia University is an affirmative action/equal opportunity employer and encourages applications from women and underrepresented minorities.

Raul Rabadan, PhD

Assistant Professor
Department of Biomedical Informatics Center for Computational Biology and Bioinformatics

Columbia University College of Physicians and Surgeons
1130 St. Nicholas Ave
ICRC Bldg 8th Floor, Office 803B
New York, NY 10032

posted 2011.05.09

Senior Scientific Researcher - Computational Biology Software Programmer open

Located in Austin, TX, Seralogix is a systems biology bioinformatics and research company with a mission to make breakthrough medical discoveries for diagnosing and treating diseases of high public health concern. Seralogix is developing state-of-the-art computational systems biology methods and tools in one of the fastest moving fields today.

We are seeking software programmers with strong mathematical background to support research and development of computationally intensive systems biology software employing a variety of algorithms including machine learning and Bayesian techniques. The successful applicant will be responsible for new algorithmic development, software implementation, contributing to publications, grant writing, and interacting with Seralogix's clients.

Preferred candidate background is in computer science, computational biology, math, operations research, physics or statistics with a variety of combinations of degree and experience being considered (BS/MS with directly applicable industry experience or PhD with applicable postdoc). Experience in bioinformatics, systems biology, data mining or pattern recognition is important. Candidate should ideally have familiarity with genomics, proteomics and metabolomics and have some experience in microarray, mass spec, and next generation sequencing data processing and analysis.

The candidate should be fluent in Java, R, SQL and Perl, PHP or similar programming language, C++, MATLAB a plus. Proven ability to design and implement computational algorithms, user interfaces, APIs. Installing, configuring, and maintaining RDBMSs and developing software using RDBMS APIs. Candidate should have hands on experience with Linux and Microsoft operating systems.

The candidate should be able to demonstrate the ability to quickly learn and apply methods and procedures to accomplish research and development objectives. The ideal candidate must have demonstrated ability to:
- Develop scientific-based software independently and in a team environment.
- Design and implement statistical and probability algorithms
- Communicate the algorithms and/or results to both technical and non-technical audiences.

Salary commensurate with experience and education. Comprehensive benefits included.

To Apply: Send your Resume of CV to careers @ seralogix.com.

Website: www.seralogix.com

posted 2011.04.27

Research Assistant (2 year post): Semantic Web & Biomedical Ontologist open

DERI - National University of Ireland, Galway

The Unit for Health Care and Life Sciences (HCLS) at the Digital Enterprise Research Institute (DERI: http://www.deri.ie/) of the National University of Ireland, Galway invites applications for two research assistant positions.

DERI is a leading research institute in semantic technologies that offers a stimulating, dynamic and multi-cultural research environment, excellent ties to research-groups worldwide, close collaboration with industrial partners and up-to-date infrastructure and resources.

 The DERI HCLS group has embarked on an ambitious European FP7 project which uses semantic web technologies to enable sharing and collaboration between life scientists in cancer chemoprevention. Research in the DERI HCLS research group is carried out in close collaboration with other research units in DERI, along with other collaborating institutions and industrial partners.

The successful candidates will have key roles in this project as DERI's role and experience in Linked Data is central to the technology to be used in the project. Candidates should have at least two of the following:

  • Previous experience with Linked Data/SPARQL/Semantic Web tools
  • Previous experience with Biomedical Ontologies, in specific NCBO
  • Previous work with wet lab /bench researchers; knowledge about biomedical databases,  commonly used biological UI (genome browsers, clustering tools) and commonly used Bioinformatics tools (BLAST, CLUSTAL-W, etc)
  • Knowledge about deployment of web services/API/Domain specific languages
  • Experience with Natural Language Processing tools, preferably with extraction from PDF

 Successful candidates are expected to have the willingness to combine formal scientific work, design, and implementation, with hands-on evaluation with life scientists.

Please send your application (CV, two letters of reference) in PDF format to the email address below - by April 1st, 2011

Further details can be obtained from:

 

Ronan Fox

Domain for Health Care and Life Sciences

DERI - National University of Ireland, Galway

IDA Business Park,

Lower Dangan,

Galway, Ireland

 

ronan.fox@deri.org

posted 2011.03.31

Expert in bioinformatics - Systems Modeling open

 A senior postdoc ("experienced researcher") position is available at BRFAA (http://www.bioacademy.gr/) as part of the FP7 Infrastructure grant "TRANSMED" (Translating basic research findings in major human diseases: emphasis on obesity, metabolic syndrome and neurodegeneration) (http://www.bioacademy.gr/transmed).

 Candidates should have a PhD in Bioengineering, Bioinformatics, or related disciplines, and at least 3 years experience in data analysis and systems modeling. Experience in signal processing, pattern recognition, predictive modeling, dynamical systems, and programming in Matlab will also be an advantage.

 The successful candidate will collaborate with members of the TRANSMED consortium on translational medicine projects and (i) provide expertise in bioinformatics data analysis, data mining,  and simulation methods to formulate new hypotheses based on the integration heterogeneous data sources (genomic, proteomic, imaging), (ii) provide expertise for the development of a translational bioinformatics platform supporting the full research cycle of storage, integrative data analysis/visualization: from databases of clinical and molecular data to pathway analysis, network inference,  mathematical model building for in-silico prediction.

 The position is available for a duration of 18 months. Interested candidates should
 send their CV, including contact details for 3 referees, and a letter of intent to:
 Prof. Elias S. Manolakos,eliasm@di.uoa.gr,
 Dr.Leonidas  Stefanis,lstefanis@bioacademy.gr  and
 Dr. Katia Karalis,kkarali@bioacademy.gr.

 Closing date: 16/05/2011
 Employment start date: 01/07/2011
 Contract length: 18 months
 Institution: Biomedical Research Foundation of the Academy of Athens.
 Contact Information:Prof. Elias S.  Manolakos, Affiliated Investigator.

posted 2011.03.30

Senior Scientist (Postdoc) Skin Biology (m/f) open

Within the frame of multiple systems biological projects funded by the German Ministry for Education and Research (BMBF: MEDSYS, FORSYS) the Hamamatsu TIGA (Tissue Imaging and Analysis) Center of the University Hospital Heidelberg is looking for a

Post-Doc in Skin Biology

Environment: The TIGA Center is a cooperative unit with multiple partners and is hosted in the internationally leading systems biological center BIOQUANT at the University Heidelberg. You will work in close collaboration with multiple research groups of the University Hospital (e.g. National Center for Tumor Diseases), German Cancer Research Center (DKFZ) and others. The open position therefore offers an exciting environment for interdisciplinary research at the pulse of modern systems biology. We offer a friendly and dynamic working atmosphere where you have the unique opportunity to work daily with experimentalists and computer scientists in our own and related groups to optimally continue your scientific career. The TIGA is running manifold research projects covering clinically relevant questions in terms of the semi-automatic and automatic processing of tissues by using organotypic tissue cultures, automated immunohistochemistry, high-throughput microscopy, particularly virtual microscopy and image analysis.

Job description: Goal of the cooperative MedSys-project is the development of an integrated approach towards the understanding of wound healing. Using in vitro-, in vivo- and in silico models, the re-epithelialization process in healing skin wounds is studied. To this end, a multi-scale approach integrating the molecular and cell biological level is pursued with the goal of deriving therapeutically relevant insights into the molecular mechanisms of the skin. You focus on characterization and further development of our existing wound model with respect to molecular make-up including gene expression, protein analysis and specific markers. In detail you are responsible for cultivation of cells and tissues with wounding and treatment of organotypic skin cultures. Furthermore you investigate the influence of various cytokines on the re-epithelialization process of the wound model and you are responsible for the coordination of activities within the projects.

Your qualifications: You have a university degree in biology, biochemistry or other life sciences and received a PhD or comparable qualification in the field of cell biology or molecular biology. You possess a deep knowledge in skin biology and a good overall knowledge of cell biology and molecular biology. You are organized, self-motivated and possess good interpersonal skills that enable you to work within and across interdisciplinary teams. Also we expect a strong interest for systems biology, the ability to communicate in English in daily routine and to write scientific publications. Participation in teaching is welcome.

To apply: Please upload a single pdf file including: (1) a cover letter explaining why you would like to join our Institute, (2) your detailed CV including your publication list, (3) description of previous scientific experience, (4) your future research plans and (5) contact details for 2 academic references who are willing to write a reference letter on your behalf.

The position is currently limited for 2 years. Salary is according to TV-L 13. The University of
Heidelberg is an equal opportunity employer.

Please send your application till 30. April 2011 exclusively by e-mail to: tiga.jobs @ googlemail.com

PD Dr. Niels Grabe, Institute for Medical Biometry and Informatics, University Hospital Heidelberg.

posted 2011.03.23

Postdoctoral position - Cancer Systems Biology open

Date posted: February 24, 2011
Application deadline: open until filled

A postdoctoral position is open at Institut Curie, Paris (http://www.curie.fr) as a joint appointment in the "Immunity and cancer" Unit led by Vassili Soumelis and the "Bioinformatics and Computational Systems Biology of Cancer" Unit led by Emmanuel Barillot. This position is supported by a 6-12 months start-up funding, which will have to be followed by application to individual post-doctoral fellowships.

Context:
Institut Curie is one of the biggest European institutions for cancer research with strong and old interdisciplinary traditions. It also comprises a hospital specialized in cancer treatment, and therefore dispose of a continuum of expertise from fundamental research to patient care. It is located in the center of Paris in a both cultural and scientific rich environment. The project will be co-developed by the "Immunity and cancer" Unit and "Bioinformatics and Computational Systems Biology of Cancer" Unit. Those immunology and bioinformatics teams have established a tight and fruitful collaboration, which has been successful over the past few years to improve our understanding of complex inflammatory and immune reactions.

Project:
Living systems are open systems that change state and behavior in relation to their environment. Conversely, their state impact the way they respond to given environmental stimuli. Hence, the state of a living system is highly intricated with its environment.
In this project, we consider the cell as the system of reference. We use two models to study the reciprocal interaction between cell state and its environment.

1. Tumor development:
Tumor cell state and the surrounding microenvironment are evaluated by their transcriptional profiling, combined to multiparametric functional characterization. The successful candidate will use computational biology and modeling methods to describe and explain the complex interactions between tumor cell state and tumor microenvironment in a quantitative and multiparametric manner. It will also be important to study the impact of these biological parameters on tumor outcome and response to therapy.

2. Immune cell behavior:
we study dendritic cells of the immune system to address their interaction with environmental stimuli during an immune response. As for project 1, transcriptional profiling is mostly used in order to assess the global state of the cells, and how this states impacts the cell response to individual or combined environmental stimuli.

Profile:
Ideal candidate would have a PhD in statistics, applied mathematics, bioinformatics or biology and good publication records. Theoretical and applied knowledge in statistical signal processing, estimation theory, random processes theory, model selection theory will be valued.
Some knowledge of cancer biology, cell biology and/or immunology is not mandatory but would be appreciated. Excellent communication skills and team spirit as well as a capacity to work in autonomy are essential. Both projects involve a tight interaction between computational and experimental work.

Contact:
For any questions about this position or to submit an application (a letter of motivation, a CV and two letters of reference), please contact:

Alix Scholer-Dahirel, PhD
Institut Curie
26 rue d'Ulm, 75005 Paris, France
Tel: +33 (0)1 56 24 58 05
bcsb47 at curie.fr

posted 2011.03.08

Post doc in computational design of multicellular systems open

In the frame of a collaborative project between INRIA (Paris), Verimag (Grenoble) and MIT (Boston), we are looking for a postdoctoral researcher to work on computational design of multicellular systems. The goal of the project is to engineer a genetic system enforcing artificial tissue homoeostasis.
The postdoc will be in charge of developing novel computational approaches for guiding tissue design, and of applying them to assist the experimental work currently done in the Weiss Lab. From a methodological point of view, this task consists in computing abstract cell population models from (a population of) single cell models.

The research will be carried out at INRIA Paris. The Contraintes research group has a solid expertise in the development of computational methods for the modeling and analysis of biomolecular systems. Together, the Bang research group (tissue models), the Verimag lab (formal methods), the Weiss lab (synthetic biology), and our group form a strong consortium that offers an exciting environment for interdisciplinary research.

The candidate should have a background in computer science, applied mathematics/engineering, or computational biology. The ideal candidate will have expertise in the analysis of stochastic dynamical systems, modeling in systems and synthetic biology, and programming.
The position is for 2 years and is expected to start in April 2011. The amount of the fellowship is competitive and varies according to previous experience.
Contact: Gregory Batt (gregory.batt @ inria.fr)

posted 2011.02.18

Postdoctoral Systems Biology of Ageing open

Applications are invited from highly motivated individuals to work in an interdisciplinary environment, combining mathematical modeling with molecular cell biology.

The position is available from spring 2011 for a period of up to three years and are paid according to the German academic pay scale (E13 100%), which varies with age and experience. The research is conducted as part of a research network, involving six experimental groups in the Faculty of Medicine at the University of Rostock, two industrial partners and two external academic partners in Leipzig and Lübeck. Mitochondria and ROS production are key elements in the pathogenesis of degenerative diseases which ultimately determines the overall process of ageing. The experimental partners in the network will measure data on the subcellular level from different tissues of mouse mutants. The posts will focus on mathematical modeling of ROS production in the respiratory chain in dependence on its mutation status. The modeling work is embedded in an iterative cycle of quantitative cell biology, mathematical modeling, parameter estimation, study of patterns in transient dynamics and sensitivity analysis, design of refined experiments and experimental validation of model predictions to understand ROS effects at the subcellular level.

The Department of Systems Biology & Bioinformatics provides a vibrant research environment, with extensive experience in interdisciplinary collaborations, covering a wide range of methodologies and technologies. The group moved in July 2009 into a new building and provides excellent facilities. The University of Rostock, founded in 1419, is one of the oldest in Europe. Rostock is located in the north‐east of Germany with road and train connections to Berlin and Hamburg, as well short ferry links to Denmark, Sweden and other Baltic states. The area around Rostock is one of the most popular tourist regions in Germany.

Applications, including a full CV, copies of certificates, PDFs of the main publications with description of the own contribution and contact information of three referees should be send to Prof. Olaf Wolkenhauer in PDF format by Email: peggy.sterling @ uni‐rostock.de (Subject: "ROSage").

posted 2011.02.07

Two PhD positions in Computational Biology and Biological Physics closed

The Computational Biology and Biological Physics group at Lund University is recruiting two PhD candidates in the area of dynamical modelling of gene networks, primarily in plants. The work will be done within interdisciplinary collaborations with experimental biologists. The positions are open for all nationalities and the candidates should have a bachelor's degree plus an additional full year of advanced-level courses in computational biology, physics, applied mathematics, bioinformatics, computer science or engineering, or in other ways obtained equivalent qualifications.

Further details can be found at http://cbbp.thep.lu.se/activities/phd.html
Also see the homepages of the supervisors, Henrik Jönsson and Carl Troein.

The closing date for applications is February 14, 2011. Applications should be submitted through Lund University's online application system, which can be found through the above link.

The Computational Biology and Biological Physics group is part of the Department of Astronomy and Theoretical Physics at Lund University. The group pursues a broad spectrum of research activities, in collaboration with life scientists locally and globally. In particular, the group builds models of macromolecules and living systems, and investigates biological processes by applying machine learning and statistical techniques.

Founded in 1666, Lund University is today one of the largest, oldest and broadest universities in Scandinavia and is consistently ranked among the world's top 100 universities.

posted 2011.01.31

Post-Doc Systems Biology Multi-Cellular Simulation (open) closed

In the frame of multiple systems biological projects funded by the German Ministry for Education and Research (BMBF: MEDSYS, FORSYS, Virtual Liver, GerontoSys) the Hamamatsu TIGA (Tissue Imaging and Analysis) Center of the University Hospital Heidelberg is looking for a

Post-Doc in Multi-Cellular Simulation (in Bioinformatics, Software Engineering, Visualization)

We have developed the foundations of a novel multi-cellular simulation environment based on multi-agent systems (Bioinformatics, 25(16):2057-63) for epithelial tissue, especially for the simulation of the rapid renewal process of human skin. In this simulation behavioral models of individual cells interact to form the emergent properties of epithelial tissue. We are now aiming at further developing the simulation towards a more realistic histomorphological behavior and integrating gene functions (molecular networks) into the cell behavioral models. We are looking for a skilled scientist, with experiences in software development, simulation, visualization with knowledge in bioinformatics or related disciplines. Experimental (e.g. histological) reference data are generated in our own lab from native tissue and in vitro experiments. The molecular networks to be integrated are constructed by cooperating team members and will be implemented in close collaboration.

Environment: The TIGA Center is a cooperative unit with multiple partners and is hosted in the internationally leading systems biological center BIOQUANT at the University Heidelberg. You will work in close collaboration with multiple research groups of the University Hospital (e.g. National Center for Tumor Diseases), German Cancer Research Center (DKFZ) and other groups. The open position therefore offers an exciting environment for interdisciplinary research at the pulse of modern systems biology. We offer a friendly but dynamic working atmosphere where you have the unique opportunity to daily work with experimentalists in our own and related groups to optimally continue your scientific career.

Position: We are looking for a committed and integrating personality who values this special environment and would like to contribute his or her outstanding experience. Your background could be from computer science, bioinformatics or a related discipline. The existing software package has been developed using state-of-the art software engineering techniques in JAVA. Therefore we expect according knowledge in working on larger software packages. Experience in visualization would be beneficial. Also we expect a strong interest for multi-cellular systems biology, the ability to communicate in English in daily routine and to write scientific publications. Participation in teaching is welcomed.

Your application should contain
a) a detailed CV
b) description of previous scientific experiences (please select a representative publication)
c) your interests or method spectrum
d) two possible contacts for references

The position is currently limited for 2 years. Salary is according to TV-L 13.
The University of Heidelberg is an equal opportunity employer.

Please send your application exclusively by e-mail to: tiga.jobs @ googlemail.com
PD Dr. Niels Grabe,
Institute for Medical Biometry and Informatics,
University Hospital Heidelberg.

posted 2011.01.26

Post-Doc Systems Biology Large-Scale Networks (open) closed

In the frame of multiple systems biological projects funded by the German Ministry for Education and Research (BMBF: MEDSYS, FORSYS, Virtual Liver, GERONTOSYS) the Hamamatsu TIGA (Tissue Imaging and Analysis) Center of the University Hospital Heidelberg is looking for a

Post-Doc Systems Biology / Bioinformatics: Qualitative Large-Scale Networks and Simulation.

Topic: You will work in close collaboration with multiple research groups of the University Hospital (e.g. National Center for Tumor Diseases), German Cancer Research Center (DKFZ) as well as international companies on multiple clinically relevant questions. Goal of the works is the development of algorithms for modeling and simulation of qualitative large-scale networks. The logical or qualitative networks are to be constructed from different gene and protein databases and used for interpreting experimental high-throughput data from our own lab or partners. Logical or qualitative reasoning and simulation approaches will be used for deriving predictions from the networks. Together with the project partners and other team members you will structure the projects, implement apply novel algorithms and publish the results.

Environment: The TIGA Center is a cooperative unit with multiple partners and is hosted in the internationally leading systems biological center BIOQUANT at the University Heidelberg. The open position therefore offers an exciting environment for interdisciplinary research with state-of-the art experimental and theoretical techniques. We offer a friendly but dynamic working atmosphere where you have the unique opportunity to daily work with experimentalists in our own and related groups to optimally continue your scientific career.

Position: We are looking for a committed and integrating personality who values this special environment and would like to contribute his or her outstanding experience. Your background could from bioinformatics or a related discipline. You should have demonstrated experience in developing theoretical methods for handling large-scale networks, should have sufficient software development experience and be acquainted with the according databases. Experience in dealing with microarray data is expected. We expect a demonstrated interest for systems biology and the ability to communicate in English in daily routine. Participation in teaching is welcomed.

Your application should contain
a) a detailed CV
b) description of previous scientific experiences (please select a representative publication)
c) your interests or method spectrum
d) two possible contacts for references

The position is currently limited for 2 years. Salary is according to TV-L 13.
The University of Heidelberg is an equal opportunity employer.

Please send your application exclusively by e-mail to: tiga.jobs @ googlemail.com
PD Dr. Niels Grabe,
Institute for Medical Biometry and Informatics,
University Hospital Heidelberg. 

posted 2011.01.25

Systems Biology Postdoc Position in Qatar open

Start Date: available immediately

This is a two year postdoctoral opportunity for an EE Ph.D. (Signal Processing or Controls) to retrain in the Genomic Signal Processing Lab (http://gsp.tamu.edu) under the supervision of Aniruddha Datta, Edward Dougherty, Hazem Nounou and Mohamed Nounou. The source of funding requires that the postdoc relocate to Qatar for the duration of the retraining.

The salary and benefits are as follows:
Salary: $3k - 3.5k (depending on background and experience)

Benefits according to (Texas A & M University, Qatar) TAMUQ's policy: (i) Fully-furnished apartment including utilities, (ii) Local transportation allowance (currently about $375), (iii) Annual travel allowance, (iv) Relocation allowance at the beginning and upon completion of contract, and (v) Health insurance.

If interested, please send a CV with cover letter to Aniruddha Datta (datta@ece.tamu.edu) with copy to Hazem Nounou (hazem.nounou@qatar.tamu.edu). Early application is encouraged. The position
will be filled as soon as a suitable candidate is identified.

posted 2011.01.13

Available Positions for Young Chief Investigator RIKEN Research Center for Allergy and Immunology (RCAI), Yokohama, Japan closed

Purpose
The purpose of this new program is to provide a career path for young investigators who conduct multidisciplinary and/or strategic research that will bridge immunology with other research fields. The selected Young Chief Investigators will run an independent research laboratory but will be mentored by specialists in related research fields, i.e. Group Directors (GD) and Team Leaders (TL) in all of the RIKEN Institutes, including Brain Science Institute (neuroscience), Center for Developmental Biology (developmental science), Plant Science Center (plant science), Center for Genome Medicine (SNPs), Systems and Structural Biology Center (protein research), Omics Science Center (genomics), Bioinformatics And Systems Engineering division (phenome research), Center for Research Network for Infectious Diseases (network for infectious diseases), Advanced Science Institute (basic Science), Center for Molecular Imaging Science (imaging), BioResource Center (biological resources), Harima Institute (SPring-8, XFEL), Nishina Center for Accelerator-Based Science (physics), Innovation Center, Program for Drug Discovery and Medical Technology Platforms (R&D), Biomass Engineering Program (green technologies) and Center for Computational and Quantitative Life Science (systems biology). The Young Chief Investigators are expected to be pioneers in new research fields and, if successful, they will be candidates for future TL or GD positions to establish the new research field as one of the core research programs at RIKEN RCAI.

Research structure
The Young Chief Investigator (YCI) will run the laboratory independently in terms of funding and research. The laboratory will, however, share space, equipment and facilities with a host lab (RCAI Research Group or Team). The Young Chief Investigators are supported by the following mentor system and the RCAI Program Committee and will be evaluated by the RIKEN RCAI External Advisory Council (RCAI AC) and the RCAI Internal Review Systems as described in sections 3 to 5.

Evaluation
  1. The YCI reports progress to the RCAI Program Committee twice a year.
  2. The YCI makes a presentation to the RCAI AC (once every 1-2 years) and receives their review and recommendations.
  3. In the fifth year, the YCI will be reviewed by the RCAI AC and the RCAI Internal Review Board. If successful, his/her position may be extended for two years or he/she may be encouraged to apply for TL or GD positions.
Mentors
Three specialists from related fields will serve as mentors (Refer to the figure).

  1. Mentors support the research of the YCI.
  2. Mentors provide guidance for experimental design, preparation of papers and presentations, promotion of international visibility, and obtaining research funding.
  3. Mentors attend the RCAI Program Committee meeting and offer evaluation of the YCI.
  4. Mentors provide and annual report to the Director on the YCI's research progress.
Role of the RCAI Program Committee
During the initial assessment of the proposed research project, the Committee will discuss its relevance and value as a part of the core research programs at RCAI. Subsequently, the Committee will consider necessary changes in the level of RCAI support for approved YCI (e.g. additional research budget).

Candidate eligibility and application
RIKEN RCAI opens the call for applications to the public. Potential candidates must be MD or PhD no more than 40 years old who are able to work full-time. Graduate students may also apply if the student's mentor agrees them to work as part-time researchers. The aim of this program is to facilitate multidisciplinary and strategic research in immunology.

Term and budget
The term is for 5 years (until March 31, 2016). The YCI will be evaluated at the end of the fifth year, and if it receives an excellent evaluation the term can be extended for another 2 years. (However, this possibility is contingent on the national economic status, etc.). The lab will receive a maximum annual budget of 15 million yen, which includes the YCI's salary as well as those of the other researchers in the laboratory. However, if necessary, additional funding will be considered by the RIKEN RCAI and the RCAI Program Committee.

Selection and appointment
Once the applications are received, the selection committee of the RIKEN Yokohama Institute will choose a candidate and the president of RIKEN (Dr. Ryoji Noyori: Nobel Prize Laureate for Chemistry, 2001) will appoint the YCI.

Application
Electonically submit the following documents to
Keiichi Abe (Mr.)
Personnel Group, Yokohama Research Promotion Division, RIKEN Yokohama Institute
1-7-22, Suehirocho, Tsurumi-ku, Yokohama,
Kanagawa, 230-0045, Japan
e-mail: k-abe @ riken.jp
Phone: +81-(0)45-503-9467

  1. Research plan
    This should contain the project title, background, project detail and relation to the investigator's previous research. (Maximum of 10 A4 pages, single spaced).
  2. Annual plans
    Briefly describe the annual plans for the first two years. Include for each year a detailed research plan, research goal, employment plan and budget plan. Indicate major milestones for 3rd 4th and 5th year. If there are any outside funds available to support the research, they should be itemized.
  3. Host lab
    Nominate or specify, if possible, the names of the preferred host lab(s) for your preference. RCAI will coordinate a host lab and mentors.
  4. Mentor
    Indicate the preferred field of research. Applicants may specify the preferred PI mentor.
  5. Provide a critical self-evaluation to demonstrate capability to complete the research project.
  6. A CV and two recommendation letters addressed to RIKEN RCAI Director Masaru Taniguchi are required.

Application deadline is February 11, 2011.
  • Inquiries
    Contact Dr. Haruka Iwano, Research Coordinator at RIKEN RCAI, at haruka @ rcai.riken.jp for any inquiries.

http://www.rcai.riken.jp/english/recruitment/101222/

posted 2011.01.12

Postdoc Researcher in Microbial Metabolic Network Modeling open

Geomicrobial Kinetic Research (http://pages.uoregon.edu/qjin/) at the University of Oregon is looking for a postdoctoral researcher to develop and apply genome-based simulation approaches for studying microbes of environmental significance. Successful candidates will construct biochemical reaction networks based on genome sequences, and perform kinetic/flux-based simulations to study the interactions between environmental chemistry and metabolic functions. Ph.D. in related fields is required. Preference will be given to candidates with a proven publication record. Applicants should send a cover letter with a current CV and contact information for three references to Qusheng Jin, qjin @ uoregon.edu.

Salary is dependent upon experience. The University offers a comprehensive and largely employer-paid benefits package including medical insurance and retirement. The University of Oregon is an Equal Opportunity/Affirmative Action Institution committed to cultural diversity and compliance with the Americans with Disabilities Act. Women and minorities encouraged to apply. We invite applications from qualified candidates who share our commitment to diversity.

posted 2011.01.12

Postdoctoral Research Fellow in Quantitative Systems Biology closed

The Quantitative Systems Biology group, within the Clinical Sciences Centre of the Medical Research Council and the Faculty of Medicine of Imperial College in London (UK), is seeking postdoctoral candidates with a motivated interest in interdisciplinary research, aimed towards a quantitative understanding of the function of complex biological systems. The successful applicant will investigate the quantitative and systems-level properties of signaling, genetic and transcriptional networks in primary T lymphocytes, carrying out projects that integrate experimental measurements with data analysis and mathematical modeling.

The successful candidate will have recently completed a Ph.D. in a biological discipline with a strong publication record. In addition, a sound knowledge of the standard laboratory techniques of molecular and cell biology is expected, as well as experience with immunoassays, flow cytometry, and handing of primary cells. Familiarity with protein biochemistry, small RNAs, high-throughput methods for the analysis of genomes, transcriptomes or proteomes and a working knowledge of mathematical and computational methods will be advantageous.  We are a recently established and expanding research lab seeking enthusiasm, flexibility and willingness to learn across disciplines.

Additional information can be found on our website http://qsb.csc.mrc.ac.uk. Informal enquiries about the research projects are particularly encouraged and should be made to Dr Alberto Polleri, Group Head, at polleri @ csc.mrc.ac.uk

This post is a Career Development Fellowship to support post-doctoral scientists in early or changed career training and help establish them as a successful and independent research scientist in their chosen field. It is a 3-year training and development post, which incorporates both scientific and transferable skills training.

Applications are handled by the RCUK Shared Services Centre; to apply please visit our job board at https://ext.ssc.rcuk.ac.uk and complete an online application form.  Applicants who would like to receive this advert in an alternative format (e.g. large print, Braille, audio or hard copy), or who are unable to apply online should contact us by telephone on 01793 867003, Please quote reference number IRC9910.  

Closing date for applications: 13th January 2011.

The MRC is an Equal Opportunities Employer

Final appointments will be subject to a pre employment screening

posted 2011.01.12


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