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2012

Researcher / Post-Doc Positions Available for Disease Systems Modeling open

Positions open at Kitano group at a new center at RIKEN. Integrative Medical Sciences Center will be established in RIKEN Yokohama starting April 2013. Researchers and post-doc positions are available. Dr. Hiroaki Kitano will be directing Disease Systems Modeling Group and will be responsible on systems biology approach to explore new prevention and cure for disease areas center will be focusing on that are atopic dermatitis and auto-immune disorders. The group will mainly work on computational side but will secure dedicated "wet" experimental facilities so that both dry and wet work can be done an integrated manner. The team will not only work with other groups in RIKEN, but also work with the team in Okinawa Institute of Science and Technology (OIST) and the Systems Biology Institute (SBI)

Application deadline is 15 January 2013
The team will most likely to be very international team,  with English as a main working language. 

For details, please check the website:

posted 2012.12.29

Research Associate/Postdoctoral Fellow open

December 17, 2012

Brigham and Women's Hospital/Harvard Medical School
Longwood Medical Area, Boston, MA

Research Associate/Postdoctoral Fellow

Seeking individuals with a Ph.D. or Master's degree in bioinformatics, computational biology, bioengineering, or related field with a strong background in using system biology approaches to understand normal and disease physiology. The successful candidate will join an interdisciplinary team using network-based methods to uncover the underlying determinants of common intermediate pathophenotypes that contribute to cardiovascular disease. Experience with statistical and programming languages is preferred. Experience with transcriptomic/genomic based-research, inflammation or thrombosis, and/or wet lab skills would be helpful, but not required.

Interested candidates should send their curriculum vitae along with the names and contact information of three references to the attention of Joseph Loscalzo, M.D., Ph.D. care of Stephanie Tribuna at the following email address: stribuna @ partners.org.
Applicants must be US citizens, permanent residents, or eligible for a J1 visa.

posted 2012.12.18

Web Developer/Programmer Position at Harvard Medical School open

Web developer position available immediately in The Wall Lab at Harvard Medical School to participate in the design of mobile and web-based health applications that make diagnostic processes more efficient. Successful applicants must have superior programming skills and web design capabilities. We are looking for an enthusiastic candidate interested in research, autism, and enjoys learning new web-based and programming applications.

You will be designing a cloud-based web application for scientific research with multiple user login, administrative backend, and secure data collection and reporting.

Required:
Expertise in Python, HTML, MySQL, CSS, git (and github), and Unix command-line tools
Experience in web development with Django or other Python web frameworks (Flask, Pyramid, etc.)
Basic knowledge of system administration and security best-practices
Preferred: Highly preferred:
experience with Amazon Web Services or other cloud computing environments
knowledge of encryption and secure transmission/storage of data and files
Bachelor's degree in Computer Science or related discipline
Experience in team-based development
Willingness to learn new applications
Please respond with a cover letter and resume when applying.
Jena Daniels
Study Coordinator
The Wall Lab: Harvard Medical School
(603) 661-1312
http://wall.hms.harvard.edu

posted 2012.12.18

CHAIR IN METABOLIC SYSTEMS BIOLOGY open

LEONARD P ULLMANN CHAIR IN METABOLIC SYSTEMS BIOLOGY
CHARLES PERKINS CENTRE / FACULTIES OF SCIENCE AND MEDICINE
REFERENCE NO. 942/0612
  • Lead world-changing research to improve health outcomes
  • Lead systems metabolism research and education
  • Unique opportunity to be part of a rich multidisciplinary community
The University has applied its internationally recognised academic credentials to ease the burden of obesity, diabetes and cardiovascular disease by forming the Charles Perkins Centre - a unique collaboration of scholars across many disciplines.

To this end, we are seeking a scholar of international distinction to join us in leading cross-disciplinary research that translates into real-world solutions.

This position will sit within one of the four main research domains within the centre: the biological mechanisms of disease. You will lead the development of research into the functioning of metabolic systems in healthy and diseased states. You will lead education in this area for the centre, and may also be asked to assume the role of Domain Leader and to sit as a member of the Executive Committee for the Charles Perkins Centre.

You will be based in the Charles Perkins Centre's new 47,000 m2 building, and will be appointed jointly through the Faculty of Science and the Faculty of Medicine.

As Chair/Professor, you will:
  • provide leadership in scholarship through innovative and distinguished research
  • attract and build strong strategic alliances in metabolic research across universities, academic and health related organisations, government, philanthropic organisations, the media, and the general public
  • foster an environment for collaboration and synergy among Charles Perkins Centre members across all disciplines
  • engage your vision and enthusiasm to foster excellence in scholarship, in promoting research and research policy and in developing research training
  • utilise your excellent management skills to provide leadership in policy development and the development of staff
  • draw upon your experience in leading research teams to build successful teams and obtain substantial funding to support a research program
  • provide leadership in postgraduate teaching and research training
  • take an active role in the development of cross-disciplinary educational programs and in the promotion of innovation in curriculum design and teaching methods.
Term and remuneration
The position is full-time continuing, subject to the completion of a satisfactory probation period for new appointees. Membership of a University approved superannuation scheme is a condition of employment for new appointees. The successful candidate will be offered an attractive remuneration package commensurate with the responsibilities of the position and the candidate's relevant experience and qualifications.

How to apply
For more information and to apply, search by the reference number at sydney.edu.au/positions
Specific enquiries about the role can be directed to Professor Stephen Simpson, Academic Director, on +61 2 9351 5633 or stephen.simpson @ sydney.edu.au Enquiries about the recruitment process can be directed to Rodney Waterson on +61 2 8627 1214.

CLOSING DATE: 27 January 2013

posted 2012.12.14

CHAIR IN OBESITY SCIENCE open

LEONARD P ULLMANN CHAIR IN OBESITY SCIENCE
CHARLES PERKINS CENTRE / FACULTIES OF MEDICINE AND SCIENCE
REFERENCE NO. 944/0612
  • Lead world-changing research to improve health outcomes
  • Lead the development of obesity science research and education
  • Unique opportunity to be part of a rich multidisciplinary community
The University has applied its internationally recognised academic credentials to ease the burden of obesity, diabetes and cardiovascular disease by forming the Charles Perkins Centre - a unique collaboration of scholars across many disciplines.

To this end, we are seeking a scholar of international distinction to join us in leading cross-disciplinary research that translates into real-world solutions.

This position will sit within two of the four research domains within the centre: the biological mechanisms of disease, and developing new solutions for the prevention, management and treatment of disease. You will be expected to lead the development of research into the biological mechanisms and consequences of obesity, and to contribute to the development of new educational programs in the centre. You may also be asked to assume the role of Domain Leader and to sit as a member of the Executive Committee for the Charles Perkins Centre.

The position will be based in the Charles Perkins Centre's new 47,000 m2 building and will be appointed jointly through the Faculty of Medicine and the Faculty of Science.

As Chair/Professor, you will:
  • provide leadership in scholarship through original and distinguished research
  • attract and build strong strategic alliances and research collaborations in obesity research
  • foster an environment for collaboration and synergy among centre members across all disciplines
  • engage your vision and enthusiasm to foster excellence in scholarship, in promoting research and research policy and in encouraging and developing research training
  • utilise your excellent management skills to provide leadership in policy development and to encourage the development of staff
  • build successful research teams and obtain substantial funding to support a research program
  • build successful partnerships with stakeholders such as universities, academic and health related organisations, government, philanthropic organisations, the media, and the general public
  • provide leadership in postgraduate teaching and research training
  • take an active role in the development of cross-disciplinary educational programs and in the promotion of innovation in curriculum design and teaching methods.
Term and remuneration
The position is full-time continuing, subject to the completion of a satisfactory probation period for new appointees. Membership of a University approved superannuation scheme is a condition of employment for new appointees. The successful candidate will be offered an attractive remuneration package commensurate with the responsibilities of the position and the candidate's relevant experience and qualifications.

How to apply
For more information and to apply, search by the reference number at sydney.edu.au/positions
Specific enquiries about the role can be directed to Professor Stephen Simpson, Academic Director, on +61 2 9351 5633 or stephen.simpson @ sydney.edu.au Enquiries about the recruitment process can be directed to Rodney Waterson on +61 2 8627 1214.

CLOSING DATE: 27 January 2012

posted 2012.12.14

Postdoctoral Associate Position(s) open

In a pioneering national initiative, Qatar Computing Research Institute was established two years ago by Qatar Foundation for Education, Science and Community Development. Located in Doha, Qatar, QCRI seeks candidates for postdoctoral associate positions in:

Bioinformatics and Systems Biology for genetic mappings.
This work will help provide a sound foundation for human association studies that seek to link variations in our genomes to our propensity for human disease.
Discovering mechanistic linkages to disease causing genes will provide clues that can help the development of disease therapeutics and provide important prognostic information.

Dr. Bensmail, working closely with the Shafallah Genetics center to attack the classical genetics problems such as consanguinity through the analysis of high-throughput DNA sequencing.
A robust method for determining the genetic elements that underlie a phenotype is to gather groups of individuals of opposite phenotypes, interrogate the genome sequences of each group, and identify elements that are present in different proportions between the groups. Our work is using this approach computational methodologies for analyzing high-throughput DNA sequencing reads obtained from large pools of phenotypically-extreme individuals.

Candidates must hold a Ph.D. degree in bioinformatics, systems biology, or a closely related field. In-depth experience with large-scale data analysis using Linux-based systems with perl/python and R (or equivalent) is required. A strong background in statistics (hypothesis testing) is a plus. Candidates should have demonstrated creative computational analysis on projects from start to finish as proven by a solid publication track record.

QCRI, a proud member of Qatar Foundation for Education, Science and Community Development (QF), is building a multidisciplinary research group in computer science synonymous with innovation, excellence and expertise. The QCRI research program offers a collaborative, multidisciplinary team environment, endowed with a comprehensive
support infrastructure. Details regarding the QCRI research program and facilities can be accessed at http://www.qcri.com.

Salary is commensurate with experience and is accompanied by an attractive foreign-service benefits package, including paid housing and a car allowance.

Qualified applicants are invited to submit a letter of application, which should outline their interest in the position, along with their curriculum vitae including the names and contact details of three referees to info @ qcri.org or directly to hbensmail @ qf.org.qa

Positions are open until filled. Please note that, due to the high volume of applications, only short-listed candidates will be contacted.
QCRI is an equal opportunity employer committed to excellence through diversity.

posted 2012.11.27

Department Chair of Biological Sciences Professor in Systems Biology Southern Methodist University open

The Department of Biological Sciences at SMU invites applications for the position of Departmental Chair (Position No. 6024), starting in August 2013. The successful applicant will have a Ph.D. degree, a strong record of academic achievement and extramural funding, experience in graduate student education, and enthusiasm for mentoring faculty. It is anticipated that the successful candidate will lead a transformation of the department into one with a strong emphasis in Systems Biology. This effort will include the hiring of several additional faculty members, including at least one endowed chair, and the creation of a vibrant Systems group that will also complement existing departmental strengths. Resources available include high-performance computing facilities and opportunities for interdisciplinary interactions with faculty conducting relevant research in other departments. For further information please visit our website (http://smu.edu/biology). Applicants at the Associate and Full Professor levels will be considered. Applications may be submitted electronically or by letter, and should include a statement of interest, curriculum vita, and the names and contact information for three professional references. To ensure full consideration, the application must be received by December 1, 2012, but the committee will continue to accept applications until the position is filled.

Applications should be sent to Steven Vik, Department of Biological Sciences, Southern Methodist University, P.O. Box 750376, Dallas, Texas 75275 or to svik @ smu.edu.

SMU will not discriminate on the basis of race, color, religion, national origin, sex, age, disability, or veteran status. We particularly welcome applications from minority and women scholars. SMU is also committed to the principle of nondiscrimination on the basis of sexual orientation. Hiring is contingent upon the satisfactory completion of a background check.

posted 2012.11.14

Faculty Positions in Interdisciplinary Science/Science Education Research open

Virginia Tech College of Science
Faculty Positions in Interdisciplinary Science/Science Education Research
 
The College of Science at Virginia Tech (http://science.vt.edu) is expanding its research presence in teaching and learning of undergraduate science with two tenure-track openings in interdisciplinary science/science education, to start Fall 2013 at our Blacksburg, VA Campus. Appointments at the rank of Assistant, Associate, or Full Professor will be made in one of the College's eight departments:  biological sciences, chemistry, economics, geosciences, mathematics, physics, psychology, and statistics. The position signifies a continued University commitment to the importance of educating future STEM professionals, empowering them to address major interdisciplinary societal challenges in energy, the environment, and health. The new faculty members will participate in the College of Science's recently launched Integrated Science Curriculum (www.science.vt.edu/isc), which serves to build strong research and educational partnerships across the sciences and mathematics. Appointments will be made within the departments that best suit the background and interests of the successful candidates.
 
Job requirements include a Ph.D. in a scientific field, a research focus in interdisciplinary science/science education, and experience teaching science.  The successful candidate will be expected to establish a vigorous research program and to provide effective instruction and advising to a diverse population of undergraduate and graduate students. Other responsibilities include continuing development of professional capabilities and scholarly activities, travel to professional conferences, curriculum development, participation in department, college, and university governance, and professional service. The faculty handbook (available athttp://www.provost.vt.edu) provides a complete description of faculty responsibilities.
 
Preference will be given to scientists experienced in undergraduate interdisciplinary science teaching and learning who demonstrate the potential to create an outstanding research program that explores topics in interdisciplinary science/science education.  Science research interests that intersect with existing areas of STEM education at Virginia Tech will be looked upon favorably.
 
Further information can be found at www.science.vt.edu. Questions regarding the position can be directed to Dr. Barbara Bekken, (bekken@vt.edu).  Applications must be submitted online at http://listings.jobs.vt.edu (#TR0122516) and should include a cover letter, curriculum vitae, a research plan, a statement of teaching philosophy that describes an integrated vision for learning in the sciences, and an annotated list of up to five references.  Review of applications will begin on December 1, 2012 and continue until the position is filled. As part of the hiring process, the successful applicant must pass a criminal background check. 
 
Virginia Tech is an EO/AA university, and offers a wide range of networking and development opportunities to women and minorities in science and engineering. Individuals with disabilities desiring accommodation in the application process should notify Ms. Mikhelle Taylor, College of Science, (540) 231-5422, or call TTY 1-800-828-1120.
 

posted 2012.11.09

ASSISTANT PROFESSOR, TENURE-TRACK BIOINFORMATICS/COMPUTATIONAL BIOLOGY open

BIOINFORMATICS/COMPUTATIONAL BIOLOGY
ASSISTANT PROFESSOR, TENURE-TRACK
DEPARTMENT OF BIOLOGY
COLORADO STATE UNIVERSITY

POSITION: The Department of Biology at Colorado State University (Fort Collins, Colorado) is recruiting a biologist advancing areas of bioinformatics or computational biology for a tenure track position at the rank of ASSISTANT PROFESSOR. Relevant areas of interest include (but are not limited to) epigenomics, evolutionary genomics, metagenomics, molecular or physiological imaging, systems biology, or synthetic biology. This is one of three positions in a cluster hire in Bioinformatics and Computational Biology launched in the College of Natural Sciences. As part of this effort, the Department of Computer Sciences and the Department of Statistics are also conducting independent faculty searches. Information about those positions can be found at:

DEPARTMENT: The Department of Biology at Colorado State University (CSU) is one of eight departments in the College of Natural Sciences. The Department has a strong commitment to undergraduate and graduate teaching, as well as excellence in research supported by more than $30 million dollars in active grants. The Department is home to about 1,450 undergraduate majors, 80 graduate students, 25 postdoctoral fellows, and 29 regular faculty members. Research interests range from molecules to ecosystems. For more information about the Department,

posted 2012.10.24

Postdoctoral position in computational biology open

A postdoctoral position is available immediately in the laboratory of Olivier Cinquin at UC Irvine, to develop computational tools that enable groundbreaking approaches to the fundamental relationship between cell cycling, mutation accumulation, and aging. The aging process has a complex relationship with cell cycling: cell cycling maintains organ function by ensuring self-renewal, but this cycling is thought to drive mutation accumulation, and to eventually lead to senescence. Our long-term aim is to elucidate the strategies used by animals to minimize the negative impact of cell cycling, and to elucidate the compromises made between self-renewal and mutation accrual. Our approach relies in large part on a computational pipeline that quantifies raw, experimental data (especially microscopy images) and extracts high-level features that can be used for machine learning. Our pipeline was designed for our own purposes and our own model system (the round worm C. elegans), but is finding uses in unrelated biological fields.

An important part of the successful applicant's project will be to design new analysis tools, design a NoSQL database to store raw data and analysis results, and actively participate in the biological interpretation of aggregated results. Numerous further projects are available for the successful applicant to explore and develop depending on his/her interests.

Applicants should hold a PhD in a theoretical discipline such as computer science. Applicants must have experience with Java and UNIX, an understanding of image processing algorithms, and a strong desire to interact with biologists. Also desirable are experience with machine learning techniques, experience with NoSQL databases such as db4o or MongoDB, experience with matrix libraries such as Colt or UJMP, knowledge of C/C++, a good understanding of performance issues and concurrency pitfalls, and experience with GPU programming.

UC Irvine provides an outstanding environment for postdoctoral scholars to broaden their skills and research interests, thanks to multidisciplinary structures such as the Center for Complex Biological Systems, one of only 13 NIH-funded national systems biology centers, or the Institute for Genomics and Bioinformatics. UC Irvine is located in Southern California, which offers clement weather throughout the year as well as numerous opportunities for outdoor activities.

To apply, send a statement of research accomplishments and interests, a CV, and have three reference letters sent directly to Olivier Cinquin, Dept. of Developmental and Cell Biology, 4103 McGaugh Hall, University of California, Irvine, CA 92697-2300, or olivier.cinquin@uci.edu by 11/1/2012.  The University of California, Irvine is an equal opportunity employer committed to excellence through diversity.

posted 2012.09.07

Postdoctoral position in systems biology of aging open

A postdoctoral position is available immediately in the laboratory of Olivier Cinquin at UC Irvine, to dissect the relationship between cell cycling, mutation accumulation, and aging. The aging process has a complex relationship with cell cycling: cell cycling maintains organ function by ensuring self-renewal, but this cycling is thought to drive mutation accumulation, and to eventually lead to senescence. Our long-term aim is to elucidate the strategies used by animals to minimize the negative impact of cell cycling, and to elucidate the compromises made between self-renewal and mutation accrual. We are establishing germline stem cells of the roundworm C. elegans as a uniquely-powerful model system to study these strategies, by asking new systems-level questions and by developing new molecular assays as well as cutting-edge computational tools.

Various specific projects are already available in the laboratory, but the successful applicant will be given the opportunity to further define his/her own project according to his/her interests. Applicants should hold a PhD in biology, or hold a PhD in a theoretical discipline and have demonstrated ability to learn experimental techniques. Prior experience with C. elegans is not required.

UC Irvine provides an outstanding environment for postdoctoral scholars to broaden their skills and research interests, thanks to multidisciplinary structures such as the Center for Complex Biological Systems, one of only 13 NIH-funded National Centers for Systems Biology, or the Institute for Genomics and Bioinformatics. UC Irvine is located in Southern California, which offers clement weather throughout the year as well as numerous opportunities for outdoor activities.

To apply, send a statement of research accomplishments and interests, a CV, and have three reference letters sent directly to Olivier Cinquin, Dept. of Developmental and Cell Biology, 4103 McGaugh Hall, University of California, Irvine, CA 92697-2300, or olivier.cinquin@uci.edu by 11/1/2012.  The University of California, Irvine is an equal opportunity employer committed to excellence through diversity.

posted 2012.09.07

Postdoctoral Research Fellowship Programme in Youth Mental Health open

Two postdoctoral research fellowships are available from November 2012 as part of a Health Research Board funded Interdisciplinary Capacity Enhancement (ICE) Award to Department of Psychiatry, Royal College of Surgeons in Ireland and the National Suicide Research Foundation, Cork, in collaboration with Inspire Ireland Foundation and the Orygen Youth Health Research Centre, Melbourne, Australia. The ICE awards are designed as development and training awards to attract, engage and mentor future leaders in population health and health services research. A detailed training programme will be devised for both postdoctoral fellows that will incorporate a period of research experience in an international centre of excellence.

Topic: Youth Mental Health - a population-based research programme.

Post 1: Postdoctoral research fellowship in youth mental health (focus on early psychosis).
This post will be based mainly in the Department of Psychiatry, RCSI Education and Research Centre, Beaumont Hospital.

Post 2: Postdoctoral research fellowship in youth mental health (focus on suicidal behaviours among young people). This post will be based mainly in the National Suicide
Research Foundation, Cork.

Salary and duration: The postdoctoral fellowship positions are available for up to three years (full-time or potentially part-time). Salary will be based on the IUA postdoctorate researcher salary scale according to experience. Posts available from 1st November 2012 (start date negotiable). There will be a review of progress after 12 months.

Essential requirements: A PhD in a population health or mental health discipline and an excellent knowledge of epidemiology and biostatistics.

Application procedure: Interested candidates are invited to submit their CV along with a brief cover note and contact details for two referees. If candidates have a preference for a particular post please state this clearly in the cover note. Applications should be sent to
Catriona O'Grady at catogrady @ rcsi.ie.
Closing date for receipt of applications is September 17th 2012 with interviews to be held in October 2012.

For enquiries regarding these posts contact either Professor Mary Cannon, RCSI (marycannon @ rcsi.ie) or Dr Helen Keeley, NSRF (Helen.Keeley1 @ hse.ie)

Relevant recent publications by the group include:
Kelleher et al, British Journal of Psychiatry 2012; 201:26-32
Kelleher et al, Schizophrenia Bulletin 2012, 38:239-46
Clarke et al, American Journal of Psychiatry 2011;168:1295-302
Perry et al, PLoS One; 2012:7(2):e31663
Wasserman et al, BMC Public Health 2010; 10:192

posted 2012.08.27

PostDoc position available in Imperial College London open

Applications are invited for the post of Research Associate in the Department of Bioengineering at Imperial College working under the supervision of Dr Reiko Tanaka.


This post is for a project aimed at understanding design principles of biological control systems. We will employ a diverse range of theoretical/engineering methodologies to model and elucidate the regulatory mechanisms for skin barrier homeostasis and inflammatory signalling. The project will include collaboration with experimentalists and clinicians. The main responsibilities of this post will include development of mathematical models for skin barrier homeostasis and inflammation, proposition of the experiments, coordination, integration and analysis of experimental data, and the statistical analysis and reformulations of these models in light of the collected data. More information on research activities in Dr Tanaka's group is found in http://www.bg.ic.ac.uk/research/r.tanaka.

Applicants should hold a PhD or equivalent in a relevant area (Computational Biology, Control Engineering, Mathematics, Applied Mathematics, or closely aligned disciplines) to undertake this project. You should also have experience in modelling and analysis of biological systems, expertise in modelling with differential equations and numerical methods, and strong interest in biology. We look for highly motivated applicants with excellent interpersonal, written and oral communication skills and enthusiasm for exposure to a diversity of scientific projects.


For further details of the post contact Dr Reiko Tanaka (r.tanaka @ imperial.ac.uk). Interested applicants should send a current curriculum vitae and research statement to Dr Tanaka by e-mail. Candidates will be required to apply online via the Imperial College website at http://www3.imperial.ac.uk/employment where you will find a job description and person specification for this post. Please select "Job Search", then enter the job title or vacancy reference number EN20120212FH into "Keywords". Complete and upload an application form as directed.

Closing date: September 5th 2012

Start date: as soon as possible

A fixed term appointment for up to 16 months

posted 2012.08.03

A post-doctoral fellowship at Sanofi R&D open

A post-doctoral fellowship is available for a period of 18 months in the department of Structure, Design & Informatics at Sanofi R&D, Vitry-sur-Seine, France for a successful applicant with a recent PhD or up to 3 years postdoctoral experience in systems biology.
The main missions of the postdoctoral fellowship are as follows:

Apply mechanistic PK/PD simulations to drug discovery projects and contribute to the development of new drug molecules
Contribute to the precise description of selected drug target networks and their interactions with small molecular and/or biologic drugs
Initiate the construction of multi-scale computational models capable of explaining organism level PK/PD features
Contribute to the understanding of the origins of the variability in drug response at the single cell, tissue, organ and patient level that arise from differences at the level of the proteome, genome and metabolome

Experience in the systems biology field, understanding of basic pharmacology concepts and good skills in mathematics as well as knowledge of modelling tools like Matlab/Freemat, Copasi, KEGG etc are prerequisites. Good communication skills, ability to work in a collaborative fashion and proficiency in English are a must.

Sanofi is a global pharmaceutical company with more than 110 000 staff worldwide.
Our research site in Vitry (15 km from the centre of Paris) employs more than 1000 people and offers a stimulating, interdisciplinary research environment. 

posted 2012.08.03

PhD Positions: Berlin, Germany open

The Berlin Institute for Medical Systems Biology at the Max-Delbrück Center for Molecular Medicine (MDC) offers an exceptional PhD Exchange Program to support interdisciplinary research projects and international PhD education.

PhD topics are structured as collaborative projects between the Center for Genomics and Systems Biology at New York University (NYU) and the Berlin Institute for Medical Systems Biology at the MDC. A Principal Investigator from each institution supervises each student, students who are expected to divide their time between Berlin and New York, taking advantage of complimentary research and training expertise. Resources are available for travel from Berlin to New York for both short and long term working periods as well as for course and conference participation. The regular guidance of an international PhD Committee supports the creation of individual research and training portfolios.

We offer projects in the areas:
  • Systems Biology and Molecular Networks
  • Gene Regulation: microRNAs, Epigenetics, Transcription, RNA Biology
  • Bioinformatics, Computational Biology and Mathematical Modeling
  • Genomics, Proteomics, Metabolomics, Single Cell Analysis and Imaging
  • Cell Fate Conversion, Neuronal Differentiation, Reprogramming and
  • Signaling

Further information on the Institute and its mission to decipher the post-transcriptional regulatory code here: www.mdc-berlin.de/en/bimsb

The program is embedded into the research and training activities of the Helmholtz Graduate School Molecular Cell Biology (MDC) and the Department of Biology (NYU).

Online registration/application is now activated.

Application deadline is August 27th, 2012.

For more information please refer to: www.mdc-berlin.de/application

posted 2012.07.05

PhD studentship in Mathematical modelling of skin aging - Imperial College London open

We invite applications for a PhD studentship in the research collaboration between the Department of Bioengineering at Imperial College London and Johnson & Johnson, a world-leading Company for skin care products. A stipend and home/EU fees for 3 years will be awarded. 

This project aims to identify basic biological control mechanisms of pH and water content in skin and its age-dependence. The PhD student will develop mathematical tools and frameworks required to provide a unified and practically applicable model to study control mechanisms of skin aging. 

Applicants should have a Masters degree (or equivalent qualification) in a relevant area (e.g. control engineering, computational biology, applied mathematics etc.) to undertake the mathematical modelling and analysis part of this project. Experience in modelling and analysis of biological systems, expertise in modelling with differential equations and numerical methods, and strong interest in biology are preferable. We look for highly motivated applicants with excellent interpersonal, written and oral communication skills and enthusiasm for exposure to a diversity of scientific projects. The PhD will involve close interactions with biological collaborators and has the possibility to visit Johnson & Johnson in France. 

More information on research activities in Dr Tanaka's group is found in http://www.bg.ic.ac.uk/research/r.tanaka 

For further details of the post contact Dr Reiko Tanaka (r.tanaka @ imperial.ac.uk). Interested applicants should send a current curriculum vitae and research statement to Dr Tanaka by e-mail. 

Closing date: July 31st 2012

posted 2012.06.29

Research scientist and lecturer - automatic analysis of cell behavior from microscopy images open

Research scientist and lecturer - automatic analysis of cell behavior from microscopy images 

The Contents of the Postdoc´s Work: 
  • Integration into the team of automatic cell behavior analysis from time lapse microscopy: 
  • Postdoc will be integrated into the team and will be working on the task of automatic segmentation, tracking and features extraction for cell behavior analysis. 
  • Involvement in teaching of the study program (stochastic systems, design of experiment) 
  • Involvement in realization of summer school and leading of own project Involvement in project activity of the group 
Necessary documents: 
  • CV 
  • Copy of the Ph.D. degree or similar degree if studied abroad 
  • Covering letter (motivation of the postdoc) 
  • Bibliography, planning of scientific activities 

Institute: 
University of South Bohemia in České Budějovice, Faculty of fisheries and protection of waters, School of complex systems FROV JU Laboratory: The laboratory deals with the basic and applied research of complex systems especially in the natural systems area. The main direction of the research is the analysis of natural systems based on automatic data processing from the controlled experiments. The laboratory is connected to other laboratories of the School of complex systems and provides the analysis of the experimental data and software tool for annotation and evaluation. 

Key activities: 
  • controlled experiment
  • asic research of light microscopy
  • experimental data filtration
  • machine image processing 
  • multi dimensional data analysis
  • systems for moving objects tracking
  • mathematical modeling of processes 

Form of employment: 
Full time employment, place of work: The University of South Bohemia in České Budějovice, Faculty of fisheries and protection of waters, School of complex systems FROV JU, Nove Hrady 

Location: 
Czech Republic, Nove Hrady 

Possible start: 
9/2012, the contract is supposed to last for 34 months, until 30. 6. 2015. 

Salary: 
1600 EUR - 1800 EUR/month. 
More information on the Postdoc position by: http://www.frov.jcu.cz/en/volna-pracovni-mista/offer-of-jobs-2 

How to apply: 
aplication shoud be send to cisar @ frov.jcu.cz

posted 2012.06.19

Researcher/Senior Researcher Position Available open

Solve challenging problems in biology & medicine! 

Challenging projects at the forefront of research in systems biology and bio-medical research in 
  • Cancer systems biology 
  • Translational research and drug discovery with leading pharmaceutical companies 
  • Systems toxicology 
Work in small, highly dynamic and multi-cultural team involving engineers and scientists. Collaborate with global leaders in systems biology and biomedicine across industry and academia

The Systems Biology Institute (SBI, http://sbi.jp), Tokyo is looking for a researcher/senior researcher for working in research projects at the intersection of basic research and industry application of systems biology approaches. 

The Systems Biology Institute (SBI) is a non-profit private research institution established in 2000 and led by Hiroaki Kitano, a pioneer in systems biology,with the aim of promoting systems biology research and its application to medicine and global sustainability. SBI is engaged in a series of research program largely funded by branches of Japanese government and private contracts for industrial applications of systems biology research in drug discovery and other areas.

Bring in your strengths! 
  • Highly motivated individual with a passion for research and its application to real-life, industry oriented problems 
  • Ability to work in goal-oriented, milestone-driven projects 
  • Team player, able to lead projects and collaborations spanning geographies 
  • Strong knowledge of state-of-the-art computational methods, algorithms, modeling/optimization tools and databases in biology 
  • Knowledge in cancer biology, translational research, drug discovery pipeline a strong plus 
  • Programming experience in R, Matlab etc. is desirable 
  • PhD level degree in engineering or sciences and relevant experience a strong plus 
Send in your CV via email addressed to Dr.Hiroaki Kitano at info at sbi.jp Tokyo, Japan 

For details, please check http://bit.ly/we-cure 

posted 2012.06.15

PhD Studentship in Systems Biology: Predictive modelling of sodium channels dynamics in transmission of pain open

PhD Studentship in Systems Biology: Predictive modelling of sodium channels
dynamics in transmission of pain

Location: Streatham Campus, University of Exeter, EX4 4QJ.

Primary supervisor: Dr Najl Valeyev
Secondary supervisors: Dr Piet Van Der Graaf, Pfizer

Voltage-gated sodium channels produce the inward membrane current and are necessary for regenerative action potential production within the mammalian nervous system. They are expressed in primary sensory neurons and have emerged as important targets in the study of the molecular pathophysiology of pain and in the search for new pain therapies.

In order to gain new insights into the underlying molecular mechanisms of action potential alterations causing painful stimuli, we will develop an extended version of the Hodgkin-Huxley model. Our model will establish the link between membrane potential, sodium, potassium and calcium ionic concentrations within and outside the cell and the channel dynamics.

The key objectives of the studentship are to:


•Develop and validate a mathematical model that would combine sodium potassium and calcium ions channels contributing to the action potential eneration relevant to mechanisms of pain.

•Investigate the effects of individual and combined mutation-induced alterations in the current-voltage characteristics of the sodium channels on the action potential eneration. The model will also be employed in order to consider the effects of sodium channels expression, reported in pain states, on the neuronal firing characteristics.

•Utilise the model predictions in order to establish the optimal targeting regime of sodium channels blockers that allows partial or full restoration of homeostasis under the pathologic conditions. The model predictions will be tested in vitro and in vivo by the Biology group in Pfizer.

For informal enquiries, contact Dr Najl Valeyev at N.Valeyev at exeter.ac.uk.

A stipend and home UK fees for 4 years will be awarded.

Application criteria

Applicants should have or expect to achieve at least a 2:1 Honours degree, or equivalent, in maths, physics or biology.

Closing date: Applications are dealt with on rolling basis

posted 2012.06.12

Postdoctorial fellow at the University of Trento open

The Computational Oncology Laboratory at the Centre for Integrative Biology (CIBIO) at the University of Trento is seeking a postdoctoral fellow (http://www.unitn.it/en/cibio/18721/laboratory-computational-oncology).
The successful candidate will participate in the development of integrative analysis methods of orthogonal high-throughput data for the characterization of the functional impact of somatic mutations in cancer patients, using high density and Next Generation Sequencing data generated from human samples and cell lines. The candidate will participate in the development of analytical methods for the prediction of protein structural variations.
The minimum requirements include a PhD degree in Computer Science or related fields. Basic knowledge of molecular biology, genetics and cancer biology is also required.
Applicants should contact the laboratory PI, Dr. Francesca Demichelis (demichelis@science.unitn.it). Application guidelines are posted at the following web-page: http://www.unitn.it/en/cibio.

posted 2012.05.23

Job posting from The Microsoft Research - University of Trento open

The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI) is a dynamic, multicultural and multidisciplinary research center based in Northern Italy where scientists collaborate with the aim of improving the understanding of biological processes using programming languages. Along with advanced research programs, COSBI activities include many collaborations worldwide, and the development of solutions to academic and industrial partners.

 

COSBI is currently looking for highly motivated and experienced Junior Researchers / Post Doctoral Researchers: 

Junior Researcher in Ad-Hoc Language Design and Implementation

Junior Researcher in Hybrid Symulation

Junior Researcher in Computational Systems Ecology

Junior Researcher in Molecular Nutrition

Junior Researcher in Static Analysis

Junior Researcher in Bioinformatics, Data Inference and Manipulation

Junior Researcher in the field of Compilation of concurrent languages on parallel architectures

 

The positions listed above require a PhD in bioinformatics, computational biology, computer science or molecular biology and some years of research experience in the specific field.

An extensive description of our Institute and of our vacancies currently available at COSBI are given at www.cosbi.eu/index.php/people/careers.

Learn more at www.cosbi.eu!

posted 2012.04.24

Post-doctoral fellowship in molecular systems biology open

The Molecular Systems Biology Group at the Center for Neuroscience and Cell Biology (CNCB) - University of Coimbra, is seeking highly motivated candidates for a post doctoral fellowship under the project PTDC/QUI-BIQ/119657/2010 - "Finding the naturally evolved design principles of prevalent metabolic circuits", funded by FCT/MCTES (PIDDAC) and co-funded by the European Fund for Regional Development (FEDER) through "COMPETE - Programa Operacional Factores de Competitividade (POFC)". Applicants of any nationality must have a Ph. D. degree, a documented strong mathematical and computational background, and a strong publication record in computational systems biology or related areas. Documented experience in mathematical modeling of biochemical processes is a preferential condition. 

The object of activity will be the characterization of principles of quantitative design of metabolic network motifs through mathematical modeling, systems analysis and analysis of available experimental data. 

The fellowship will have the duration of 12 months, eventually renewable for an additional 12 months, to start June 2012 (negotiable). The monthly salary (tax free) will be €1495, plus €750 yearly travel allowance, plus Social Security reimbursements. 

Application deadline: 
Applications can be submitted from April 2nd to May 4th 2012 indicating reference BPD1/PTDC/QUI-BIQ/119657/2010 and including all the following documents: motivation letter, curriculum vitae, publications list, copy of Ph. D. diploma/certificate, and contact information (email and phone) of at least three references.

Applications must be submitted by email to armindo.salvador @ gmail.com. 

posted 2012.04.06

PhD Student Scholarships in Bioinformatics/Systems Biology for Systems Biology open

14 PhD research projects are offered within the JSMC Recruitment Call 2012/1 (see list at the following website). 
http://www.jsmc.uni-jena.de/phd-program/fellowship-application/vacant-projects/

posted 2012.03.29

Job opportunities in Computational and Systems Biology open

The Fondazione Edmund Mach, in Trentino, Italy, is pleased to inform you of the following open training and job opportunities:

15 Research positions in Computational and Systems Biology 
- open until the 31st July 2012;

More information:
http://www.fmach.it/FEM_work_with_us

Daniele Barbacovi
Fondazione Edmund Mach
Via Mach 1, 38010 San Michele all'Adige (TN) - Italy
Phone +39 0461 615542 - Fax + 39 0461 615183

posted 2012.03.29

Doctoral candidate position (PhD student) Systems Biology/Database and Information Systems open

Doctoral candidate position (PhD student)
Systems Biology/Database and Information Systems

Job offer opened: 26th of March, 2012

The junior research group „Simulation Experiment Management System" (SEMS) is looking for a PhD student. The offered contract is for a 40h/week, 3yrs, full time position (TVL-E13), starting from June 2012.

Area: Systems Biology, Database and Information Systems

Project objectives:
"Tools and concepts for Simulation Experiment Management in Systems Biology: Improving the production of simulation experiments through standard formats and management support" (SEMS)

Standardization efforts and the exchange of protocols to generate data in the life sciences have become a necessity for large scale projects and multinational collaborations. The data under consideration are highly context dependent and if the processes by which the data were generated are not sufficiently well documented, it becomes difficult to reproduce these results and to share and integrate results across projects. The same arguments apply to the generation of scientific results that are based on mathematical models and computer simulations. Systems biology is a scientific approach characterized by an iterative cycle of data-driven modelling and model-driven experimentation. The present project is to provide support for this iterative cycle through techniques and tools that improve and ease the working with simulation setups, in particular through better model version control.

Further information: www.sbi.uni-rostock.de/sems


Specific objectives for the PhD position:

The successful applicant for a PhD position will investigate methods and techniques for model version control. Models are here regarded as XML encodings of computational models of biological systems. Today, version changes on these models are not sufficiently stored, maintained, curated, classified and presented to the users of model databases. This project will enable model version control to ensure improved reusability of models in the computational biology field.

Main tasks
- Evaluation of existing version control techniques (XML and non-XML)
- Development of methods and concepts tailored to model version control in computational systems biology
- Development of an ontology of model changes
- Design and implementation of a database for the management of XML-encoded simulation descriptions & their integration with existing model data
- Data import, creation of sample XML files, prototype search interface

What we expect
- Experience with database systems and version control
- Experience with XML-data
- An interest in biological questions
- Good programming experience (preferred: Java)
- Good command of English
- Dedication & enthusiasm
- Master's degree or equivalent

What we offer
- International interdisciplinary training
- International working environment 
- Participation at presentations & scientific group events
- An excellent preparation for a scientific career
- Equal opportunity employer

Applications should include standard documents (cover letter, curriculum vitae, diploma certificate, etc.) and be addressed to (postal or e-mail):

Dr. Dagmar Waltemath
Department of Systems Biology and Bioinformatics
Institute for Computer Science
Ulmenstrasse 69 (building 3, 3rd floor)
18057 Rostock, Germany
dagmar.waltemath(at)uni-rostock.de

posted 2012.03.29

BIOGEMMA is seeking A System Biologist/Bioanalyst open

BIOGEMMA is seeking
A System Biologist/Bioanalyst

Biogemma is a leading European plant biotech company based in France, dedicated to research in genetics and genomics in field crops, for the improvement of native traits and the development of GM. You will be immersed in a multidisciplinary environment, where collaboration and search for innovation are crucial and permanent.

Role purpose:

Join the Genomic and Genetic Research Group, and participate to our gene candidate discovery process for plant traits and breeding by analyzing complex datasets in the context of biological pathways and omics data. Your main mission will be to responsible for the interpretation of large scale array-based data (genomics, transcriptomics, metabolomics) related to trait of interest (Yield, drought, nitrogen use efficiency...) and in relationship with quantitative genetic data. Identify and build biological networks and pathways that may help us in the understanding of such complex traits.

Primary responsibilities:
  • Analysis of transcriptomic/metabolomic data, genes networks, pathway analysis
  • Data-mining and experience with managing high throughput 'omics data as well as public repositories such as NCBI, PlexDb, Genevestigator...
Qualifications:
  •   Experience in Biology, computational biology, Bioinformatics, preferably with a focus in large scale data analysis.
  • Experience with modern high-throughput 'omics data including sequence expression, genomic variation and metabolic profiling data is highly desired.
Required skills:
  • Experience with gene expression analysis and gene interactions networks.
  • Experience with pathway databases and softwares (Pathway studio...), analysis and visualization tools such as Spotfire, GeneSpring...
  • Tools of bioanalyst (UNIX, Blast, GGB, gene prediction, promoter analysis etc...)
  • Excellent interpersonal skills,
  • Excellent verbal and written communication skills in French or/ and English.

Application instructions:
Ref 12-GGC-001-CR is mandatory when submitting your application
Apply until 30 April 2012: rh @ biogemma.com

Additional information:
Temporary contract (15 months); position based in Chappes, France (63, Puy-de-Dôme). Starting date as soon as possible.

posted 2012.03.21

Post-Doctoral Research Associate Position open

Department of Chemical Engineering
University of Massachusetts
Amherst, MA

A post-doctoral research position is available in the laboratory of Professor Michael A. Henson in the Chemical Engineering Department at the University of Massachusetts. The research involves the development of microbial metabolic models and solid-state fermentation technology for the conversion of lignocellu-losic feedstocks into precursors for high-density hydrocarbon fuels. The project is funded by the Navy through a research subcontract from PSI Inc. Close interactions with microbiologists and engineers from PSI and the Navy will be required. Candidates with a Ph.D. in chemical engineering or a related eld and the following background are sought: (1) microbial and/or solid-state fermentation; (2) genome-scale metabolic modeling; and (3) metabolic engineering.

The position is available starting April 1, 2012 for a period of 12-18 months. A nine month extension is possible with satisfactory progress and availability of funds. The stipend and bene ts are competitive. Please send a letter of application, a curriculum vitae, and three letters of recommendation to:

Dr. Michael A. Henson
Professor, Director of the Center for Process Design and Control, and Co-
director of the Institute for Massachusetts Biofuels
Department of Chemical Engineering
University of Massachusetts Amherst
686 N. Pleasant Street
Amherst, MA 01003-9303
Phone: 413-545-3481
Fax: 413-545-1647
E-mail: henson @ ecs.umass.edu

posted 2012.03.14

JUNIOR SCIENTIST (M/F) - BIOINFORMATICS/BIOSTATISTICS open

JUNIOR SCIENTIST (M/F) - BIOINFORMATICS/BIOSTATISTICS
Ref. 2011/1339

We are a member of the Helmholtz Association of German Research Centres, a leading Europe-wide association focusing on environmental health. The international research network "Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health" (HICE) investigates the effect of anthropogenic aerosols on biological systems, applying state-of-the-art analytical techniques, in order to obtain detailed information on molecular mechanisms of effect. In the framework of this interdisciplinary research project, the cooperation group Comprehensive Molecular Analytics as well as the Institute of Biomathematics and Biometry, University of Rostock, in cooperation with the Chair of Systems Biology and Bioinformatics (SBI) and the Institute for Mathematics, also located at the University of Rostock, are seeking a Junior Scientist (m/f) in Bioinformatics/Biostatistics.

Description
• Establishment and leadership of a junior research group
• Explorative data analysis of highly complex data sets
• Combination of exposure data with biological response data
• Graphic presentation of scientific data sets
• Statistical design of experiments and data management
• Supervision of PhD students
• Proactive participation in the acquisition of third party funds

Qualifications
• Successful completion of a university degree and a PhD in the areas of bioinformatics, biostatistics and/or biomathematics
• Extensive experience with data derived from scientific measurement procedures are an advantage
• Strong team skills
• Excellent knowledge of English

Work Environment and Compensation
• Innovative, well-equipped and scientifically stimulating surrounding with further training opportunities
• Initial short-term employment contract until 31 December 2014 with a standard public service salary (TVöD EG 13). In case of a positive project evaluation, an extension for another two years in the framework of the project is possible.

Application deadline: 30 March 2012.
Please send your application to Dr. Juergen Schnelle-Kreis at juergen.schnelle @ helmholtz-muenchen.de.
Further information is available at:
http://www.helmholtz-muenchen.de/en/career-and-education/ 

posted 2012.03.01

Postdoctoral Associate - Computational and Systems Biology open

The Center for Genome Dynamics (www.genomedynamics.org) is an NIGMS National Center for Systems Biology housed at The Jackson Laboratory. The Center embraces a systems approach to genetics, with an emphasis on rodent models of complex disease-related phenotypes. Center investigators have interests in computation, mathematical modeling and statistics, with a shared focus on the genetics of complex traits within the Center's collaborative and cross-disciplinary environment.

The Jackson Laboratory (www.jax.org) in Bar Harbor, Maine, USA, offers a unique research and training environment characterized by scientific collaboration, unparalleled mouse resources and outstanding core services within a spectacular setting adjacent to Acadia National Park.  The Jackson Laboratory's postdoctoral program ranks among the nation's top - voted #2 in a poll of postdocs conducted by The Scientist (2009).
 
Applicants should have a PhD (or equivalent degree) in a quantitative field such as computer science, statistics, applied mathematics or in the biological sciences but with a strong quantitative background. Applicants must demonstrate a commitment to solving biological problems. Successful applicants must have good communication skills.  Experience with scientific programming languages including java, c/c++, ruby, perl, or R is recommended. Work within the center is highly interdisciplinary, and applicants must demonstrate a desire to develop skills in new areas of science and in building strong collaborations.

Apply online at www.jax.org/careers (Job ID 2311). The Jackson Laboratory is an EOE/AA employer. 

posted 2012.02.07

POSTDOCTORAL POSITIONS IN THEORETICAL BIOPHYSICS open

Department of Health and Human Services
National Institutes of Health
National Heart, Lung and Blood Institute

Postdoctoral positions are immediately available in the Theoretical Cellular Physics Section of Biochemistry and Biophysics Center at the National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD. Applicants should have PhD in theoretical chemistry, physics, applied math or engineering. Candidates with theoretical modeling experiences in biophysics and strong computational skill are highly desirable. Projects would utilize sophisticated statistical mechanics techniques to investigate mechanochemical couplings in various cellular processes, including membrane mechanics, cytoskeleton dynamics and reaction networks. All the projects would be in extensive and close collaborations with experiments. For more information, see: http://www.lobos.nih.gov/tcps/index.shtml

Appointment and salary are dependent on experience. Applicants should submit, in a PDF file, a letter of interest, curriculum vitae, and three letters of reference to: Dr. Jian Liu at jian.liu @ nih.gov

HHS and NIH are Equal Opportunity Employers. Applications from women, minorities and persons with disabilities are strongly encouraged.

posted 2012.01.30

Doctoral Candidate in Systems Biochemistry open

The University of Luxembourg is looking for the newly established Luxembourg Centre for Systems Biomedicine (LCSB) for a Doctoral Candidate (PhD student) in Systems Biochemistry Ref.I1C-DIR-COM-11ICOO Fixed-term contract 3 years, 40h/week renewable once Student and Employee status The PhD student will be a member of the highly interdisciplinary research centre, integrating experimental biological and computational biology approaches in order to develop the foundation of a future predictive, preventive and personalised medicine. Area: Biochemistry/Medical Biochemistry/Neurochemistry. Mission: Experimental determination of metabolic flux and concentration is a critical tool for developing understanding of the physiological state of a cell. Using isotopically labeled substrates with different labeling patterns, experimental techniques are used to measure the mass isotopomer distributions of select metabolites. Estimation of metabolic flux is by integration of mass isotopomer distributions with an isotopomer (isotope isomer) mapping model, that traces the path of each isotopomer through a metabolic network. Recently an algorithm for automated generation of draft genome-scale isotopomer mapping models has been developed. The latest reconstruction of human metabolism (Recon 2.0) is a stoichiometric model of a generic human cell. It is necessary to tailor Recon 2.0 to represent the metabolic capabilities of a particular cell type of interest. Extensive manual curation of neurochemical experimental data is necessary to tailor Recon 2.0 to accurately represent the metabolism of a normal neuron. A tailored stoichiometric model of a dopaminergic neuron, that also represents atom transitions for each reaction, would be an invaluable resource for estimation of metabolic flux and concentration in cultured dopaminergic cell lines. Tasks: To address the aforementioned challenges, the PhD project objectives are: Reconstruction of a tailored stoichiometric model of a normal dopaminergic neuron by literature review. Manual curation of an existing algorithmically created draft isotopomer mapping model of Recon 2.0 to retain only biochemically realistic atom transitions. Biological interpretation of whole cell metabolic flux and concentration data in normal and diseased dopaminergic neuronal cells toward a deeper understanding of Parkinsonism pathogenesis. Profile: A broad and deep knowledge of metabolic biochemistry e.g. M.Sc. level Medical Biochemist, Biochemist, Neurochemist. Excellent English writing and speaking skills. Offer: Contribution to an international, interdisciplinary project: Dr. Karsten Hiller, LCSB, Dr. Ronan Fleming, Center for Systems Biology, University of Iceland (CSBUI).International interdisciplinary training: In the first year, a 6 month training period in metabolic network reconstruction & modeling at the CSBUI. The University of Luxembourg offers competitive salaries and is an equal opportunity employer. Application: All applications (in English) should contain the following documents: A detailed curriculum vitaeCover letter mentioning the reference number. List of publications. Description of past research experience and future interests. Name and addresses of three referees Please send your electronic applications until the Feb 3rd 2012 to the following address: katrin.effenberger@uni.lu

posted 2012.01.19

Postdoctoral Research Fellow in Computationa Systems Biology open

Application End:  Saturday March 31 2012

The Laboratory of Computational Systems Biology at the Faculty of Informatics, Masaryk University is currently expanding its research team and is looking for highly motivated and talented individuals to a three year-fixed term post.

The position is available to participate in a project focused on parameter estimation in computational systems biology.

A central challenge in computational modeling of biological systems is the determination of the model parameters. Typically, only a fraction of the parameters (such as kinetic rate constants) are experimentally measured, while the rest are often fitted. The fitting process is usually based on experimental time course measurements of observables, which are used to assign parameter values that minimize some measure of the error between these measurements and the corresponding model prediction.

The goal of our research is to develop effective, fast, and scalable methods, techniques and tools for automated parameter estimation for computational analysis of biological systems. Our approach considers a generalized form of the problem provided that traditional fitting to experimental measurements is enhanced by considering several explicit hypotheses about expected behavior of the system. We employ computer science approaches, methods and techniques as known from the analysis of computer systems (like model checking) to fit parameters according to the expected behavior.
Requirements

Candidates must hold a PhD degree (or equivalent) awarded after 1 April 2008, should be highly motivated and have either a strong background in systems biology, molecular biology, cell biology or biochemistry OR a strong background in informatics or computational modeling and an interest in biological systems. Candidate must have excellent analytical skills, and strong interpersonal and communication skills.

The deadline for applications is March 31, 2012. The gross salary is about 2200 EUR per month. The post is available from 1 September 2012, but the precise starting date is negotiable.

Interested candidates should email their CV, list of publications, brief statement of interest and career goals, names and contact information for 3 references contained in one single PDF file to:

Prof. Lubos Brim
Masaryk University Brno
Faculty of Informatics
Botanicka 68a, 602 00 Brno
Czech Republic
Email: brim at fi dot muni dot cz

posted 2012.01.05