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Doctorale Candidate (PhD student) in computational modeling of host-microbe interactions open

The University of Luxembourg has the following vacancy in the Luxembourg Centre for Systems Biomedicine (LCSB):

Doctorale Candidate (PhD student) in computational modeling of host-microbe interactions (m/f)


  • Fixed-term contract 3 years, 40h/week
  • Employee and student status (start date: as soon as possible)
  • Ref.: I1R-MSP-COM-120000
Area: Constraint-based modeling (COBRA) of host-microbe interactions

Your Role
  • Computational modeling of host metabolism and its metabolic interactions with selected microbes.
  • Reconstruction and validation against published data of the microbial metabolic reconstruction using established protocols.
  • Integration and analysis of experimental data in the microbial and host metabolic model.
  • Databases and literature mining for genomic information.
  • The project will thus include key technologies used in computational systems biology and bioinformatics.
Your Profile
  • Master´s degree (or equivalent) in Biochemistry, Medicine, (Molecular) Biology, Microbiology, or Biotechnology.
  • Strong interest in metabolism, biochemistry, and computational modeling.
  • Basic skills/ experience in programming and statistical data analysis.
  • Excellent communication skills are required.
  • Excellent working knowledge of English is required.
We offer
  • Fully funded position.
  • Working in a scientifically stimulating, innovative, dynamic, well-equipped, and international surrounding.
  • Opportunity to participate in the development of the newly created LCSB and to work closely with worldwide academic partners.
  • In-depth training in cutting edge technologies used in systems biology.
  • Numerous training opportunities in (molecular) biology, systems biology, and bioinformatics.
The University offers highly competitive salaries based on the candidate's experience and is an equal opportunity employer.

Further Information

Applications (in English) need to contain the following documents:
  • Cover letter mentioning the reference number
  • Detailed curriculum vitae
  • Description of past research experience and future interests
  • Name and addresses of three referees
For further information, please contact: Prof. Ines Thiele Ines.thiele@gmail.com
Please apply online by 20th May 2013 here: http://emea3.mrted.ly/5yr1
Relevant recent publications:
  • Thiele, I. et al.,''A community-driven global reconstruction of human metabolism'', Nat Biotech, doi:10.1038/nbt.2488 (2013). Heinken, A., Sahoo, S., Fleming, R. M. T., Thiele, I., "Systems-level characterization of the host-microbe metabolic symbiosis in the mammalian gut", Gut Microbes, 4(1):1-13 (2013).
  • Thiele, I., Heinken, A., Fleming, R.M.T. "A systems biology approach to studying the role of microbes in human health, Curr Opin Biotech, 24(1):4-12 (2013).
  • Thiele, I. and Palsson, B. O.,"''A protocol for generating a high-quality genome-scale metabolic reconstruction'', Nat Prot, 5(1): 93 - 121(2010).

posted 2013.05.07