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2014

Harvard Medical School - Postdoctoral Research Associate Position at the Center for Biomedical Informatics open

Summary:

Imagine a dynamic dataset that encompasses comprehensive information about a patient in the health care system: what diseases they have, their genomic sequence, their social media messages (e.g, tweets and likes), and where they live. How would you - a data hacker--store, retrieve, and analyze this information to drive biomedical discovery to find a new way of predicting disease or even a new therapy for a disease? The Center for Biomedical Informatics (CBMI, https://cbmi.med.harvard.edu) at Harvard Medical School is looking for a data engineer to build cutting edge platforms and data infrastructure to enable large-scale data-driven research to address this question. We aim to integrate diverse data sources from geotemporal information (e.g., HealthMaps.org and EPA AirData), individual genomic sequence, social media data, and health claims information to paint a comprehensive picture of individuals who are sick and healthy.

Responsibilities:

The Research Associate will be responsible for data harmonization and developing APIs to enable integration across diverse data modalities. The Research Associate will implement scalable statistical machine learning algorithms for prediction and discovery of clinical, genetic, and environmental factors related to disease.

The diversity of subject matter will require a creative mind and a candidate capable of deploying imaginative strategies and who is dedicated to solving complex and challenging problems within an interdisciplinary environment.

Requirements:

Candidates must have a PhD in computer science, mathematics, physics, biomedical informatics, bioinformatics, computer science, or a related quantitative field.

Preferences:

Preferred requirements for this position include experience designing large software applications and infrastructure to store, retrieve, and analyze large datasets. Industry experience with R, Python, SQL (Oracle), JavaScript is preferred. Experience in hacking with cloud technologies (e.g., Amazon, Hadoop) is a big plus and preferred.

Terms:

The position is available immediately and can be renewed annually.

How to apply:

Email applications including curriculum vitae, summary statement of personal objectives the names and email addresses of 2-3 references to Chirag Patel (chirag_patel @ hms.harvard.edu).

 

Harvard Medical School is an Equal Opportunity/Affirmative Action Employer.

Women and minorities are especially encouraged to apply.

 

posted 2014.12.18

Researcher/Senior Researcher Position at the Systems Biology Institute open

The Systems Biology Institute (SBI, http://sbi.jp), Tokyo is looking for a researcher/senior researcher for working in research projects at the intersection of basic research and industry application of systems biology approaches. 

Bring in your strengths!
Highly motivated individual with a passion for research and its application to real-life, industry oriented problems.
  
  • Ability to work in goal-oriented, milestone-driven projects
  • Team player, able to lead projects and collaborations spanning geographies
  • Strong knowledge of state-of-the-art computational methods, algorithms, modeling/optimization tools and databases in biology
  • Knowledge in cancer biology, translational research, drug discovery pipeline a strong plus Programming experience in R, Matlab etc. is desirable
  • PhD level degree in engineering or sciences and relevant experience a strong plus

Send in your CV 
Send in your CV via email addressed to Dr.Hiroaki Kitano at info @ sbi.jp

For details: please check http://bit.ly/1zd9nNM

posted 2014.12.12

Professor (all levels) in Metabolic Engineering open

King Abdullah University of Science and Technology (KAUST) (http://www.kaust.edu.sa) is seeking a highly motivated and skilled faculty member whose research focuses on metabolic pathway design, optimization, simulation, and engineering aimed at industrial biotechnology applications.

KAUST is an international, graduate-level research university dedicated to advancing science and technology through interdisciplinary research, education, and innovation. Located on the shores of the Red Sea in Saudi Arabia, KAUST offers superb research facilities, generous assured research funding, and internationally competitive salaries, attracting top international faculty, scientists, engineers, and students to conduct fundamental and goal-oriented research to address the world's pressing scientific and technological challenges in the areas of food, water, energy, and the environment.

The successful applicant is expected to develop strong research in computational design and optimization of metabolic pathways. This research will be complemented by extensive experimental research for the validation of computational designs. The faculty member is also expected to establish an experimental laboratory. The faculty member will be part of the Computational Bioscience Research Center (CBRC) within the Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division. The position will remain open until filled.

Requirements:
PhD or equivalent in a relevant discipline. Candidates should be well-established within the research field. They should demonstrate original research and experience at the highest international level.

Responsibilities and tasks:
Research competence in the following areas is preferred:
• Computational design, optimization, and simulation of metabolic pathways for the bio-production of important chemicals
•Bioinformatics analysis of transcriptomic and metabolomic data for improvement of host organisms used for the production of biochemicals
• Novel high throughput computational or experimental tools for the optimization of metabolic pathways for production of biochemicals at high yield.

Visit http://apptrkr.com/536240 to apply.

www.kaust.edu.sa

posted 2014.12.10

Postdoc in the systems biology: Modelling pattern formation and morphogenesis open

1.Job/ project description:

The main objectives of the project is to:

a) Develop mathematical models of organ development (teeth, hair and wings). The mathematical models include intracellular gene networks, cell signaling and extra-cellular signal diffusion, bio-mechanical interactions between large collectives of cells (all in 3D) (see above publications for orientative examples)

b) Develop models about the evolution of gene networks and embryonic development in general.

Since we want to understand the range of possible phenotypic variations in different animals' development we have decided to use modelling approaches. Our models take as inputs knwon or estimated gene networks and the initial distribution of cells in space (in a given stage in development) and provide as a result the final organ morphology and patterns of gene expression in a given organ (in a given, latter, stage of development). Each model is simply a mathematical implementation of a hypothesis about how an organ develops. We construct these hypotheses, based on experimental work from other groups, and implement them in a computational model. The advantage of computational models in respect to merely verbal arguments is that the models provide precise quantitative predictions that are more easily to unambigously compare with experimental results (from new experiments aimed at testing the hypothesis). Merely verbal arguments are more difficult to be proven wrong or right and get even difficult to express when the process under study involves a large number of cells in complex movement and communication between them (as it is often the case in development). These easily lead to largely unintuitive dynamics that are hard to analyze without quantitative models.

In addition, computational models allow to explore not only the wild-type but also, by variaton in the underlying gene network, the range of possible morphological variants (and how they change through development). The capacity to play with the parameters of the model allows us to actually understand its dynamics.

Ultimately, a model is simply a summary of what we think we understand about a system but that allows us to see if the underlying hypothesis could work. That the model works does not imply that the hypothesis is right, further experiments are required, but if the model can not produce the right wild-type it means that the underlying hypothesis is wrong or incomplete. In other words, what we thought we understood, we did not actually understand.

The biotechnology institute includes a range of experimental biologitst working on several systems. The supervisor of the theoretical aspects will be Dr. Salazar-Ciudad but the project would include close collaboration with Jukka Jernvall group and would include collaboration with developmental biologists, bioinformaticians, paleontologists and other evolutionary and systems biologists. The work may also include, optionally,
collaboration, and spending some time, in Barcelona.
The modeling can focus on gene network regulation, cell-cell communication, cell mechanical interactions and developmental mechanisms in general and, optionally, artifical in silica evolution.


2. Requirements:

The applicant should hold a PhD in either evolutionary biology, developmental biology, systems biology or theoretical biology. Some knowledge of ecology, zoology, cell and molecular biology are also desirable.

Bioinformaticians, systems biologists or computer biologists that do not have a degree in biology or similar similar would not be considered (this excludes Computer scientists, physicists and engineers).

Programming skills or a willingness to acquire them is required.
Familiarity with GPU computing is highly desirable.

The most important requirement is a strong interest and motivation on science, gene networks and evolution. A capacity for creative and critical thinking is also desirable.

3. Description of the position:

The fellowship will be for a period of up to 4 years (100% research work: no teaching involved).


Salary according to Finnish postdoc salaries.


4. The application must include:

-Application letter including a statement of interests
-CV (summarizing degrees obtained, subjects included in degree and
grades, average grade)

-Application should be send to Isaac Salazar-Ciudad by email:

isaac.salazar @ helsinki.fi

Foreign applicants are advised to attach an explanation of their University's grading system. Please remember that all documents should be in English (no official translation is required)

5. Examples of recent publications by Isaac Salazar-Ciudad group.

-Salazar-Ciudad I1, Marín-Riera M. Adaptive dynamics under development-based genotype-phenotype maps. Nature. 2013 May 16;497(7449):361-4.

-Salazar-Ciudad I, Jernvall J. A computational model of teeth and the developmental origins of morphological variation. Nature. 2010 Mar 25;464(7288):583-6.


6. Interested candidates should check our group webpage:

http://www.biocenter.helsinki.fi/salazar/index.html

There is no deadline, positions will be filled as they come.

Isaac Salazar-Ciudad: isaac.salazar @ helsinki.fi

posted 2014.12.10

Bioinformatics Postdoctoral Position at the Research Connection ‐ Genetics Division at Boston Children's Hospital. open

Summary
The Research Connection ‐ Genetics Division at Boston Children's Hospital is looking for  a  Postdoc  to  help  us  build  cutting  edge  research  systems.  The  real  value  in biomedical  research  lies  not  in  the  scale  of  any  single  source  of  data,  but  in  the ability  to  integrate  and  interrogate  multiple,  complementary  datasets simultaneously.  We  are  combining  clinical  and  genomics  data  on  Autism  patients across  different  scales  and  resolutions  to  enable  new  perspectives  for  essential biomedical questions.  The dataset  to be worked on  today has over 6,000 exomes, 10,000  SNP  Chip  results,  hundreds  of  microarrays,  carefully  and  professionally collected  clinical  data  as  well  as  links  to  electronic  health  records  for  the  same subjects.  As  the  project  progresses  the  incumbent  will  have  the  opportunity  to participate in data mining and research on the dataset. 

Responsibilities:
The  Postdoc will  be  responsible  for loading large  datasets into  our warehouse, all the  while  making  improvements  to  an  existing  data  loading  infrastructure. Opportunities  exist  for  publications  both  in  the  infrastructure  of  our  research environment and in novel data analysis. The diversity of subject matter will require a  creative  mind  and  a  candidate  capable  of  deploying  imaginative  strategies  and who  is  dedicated  to  solving  complex  and  challenging  problems  within  an interdisciplinary environment. 

Requirements:
Candidates  must  have  a  PhD  degree  (or  MD/PhD.)  in  biomedical  informatics, bioinformatics,  Computational  Biology,  computer  science,  or  a  related  field. Curriculum in and/or strong experience with NGS, RNA Seq will  be  necessary  for this opportunity. Experience in clinically derived data, clinical ontologies is required as  well  as  strong  experience  in  programming  and  software  development. Specifically,  experience  with  Perl,  R  and  database  programming  are  required.  The candidate interested in this position must be highly motivated, willing to learn and demonstrate  initiative  in  assigned  tasks.  Excellent  written  and  verbal communication skills are crucial. Previous experience on neurodevelopment disorders would be a plus. 

How to apply:  
Email applications to: paul_avillach @ hms.harvard.edu including:  
1) Curriculum vitae 
2) Summary statement of personal objective and research interests 
3) PDFs of the best three papers 
4) Names and email addresses of three references 

Boston Children's Hospital is an Equal Opportunity/Affirmative Action Employer.  
Women and minorities are especially encouraged to apply. 

For additional information contact: 
Paul Avillach, MD, PhD 
_______________________________________________________ 
Assistant Professor 
Center for Biomedical Informatics | Harvard Medical School 

Research  Connection    |    Children's  Hospital  Informatics  Program    |    Boston 
Children's Hospital 

posted 2014.12.04

Post Doctorate RA - Metabolic Modeling in RICHLAND Washington United States open

Job Description

The Pacific Northwest National Laboratory is seeking a motivated postdoctoral candidate with expertise in metabolic network modeling for steady-state and dynamic simulations. The ideal candidate will have extensive experience in flux balance analysis, genome-scale metabolic network reconstruction, and integrating omics-data into network models, as well as mechanistic kinetic modeling. Experience in modeling microbial communities and/or multicellular systems is strongly desired.

The successful candidate will be joining in multidisciplinary scientific teams with microbial ecologists, bioinformaticians, and analysts to develop the multitude of models of microbial consortia/communities for simulating their compositional and functional changes in response to environmental variations. He/she will also have opportunities to have access to state-of-science computational, experimental, and analytical capabilities associated with PNNL and EMSL. The postdoctoral investigator will be responsible for helping meet project requirements and assisting in the writing of manuscripts that describe project work/results. Strong communication and writing skills as well as excellent teaming relationships with experimental scientists are required. He/she will act in close collaboration with senior PNNL staff.

Minimum Requirements

Candidates must have received a PhD within the past five years from an accredited college or university.

Qualifications

The candidate should have a Ph.D. in chemical engineering, biological engineering, or related area and have a strong publication record. Expertise in at least one of the programming languages, such as Matlab, R, Java, Python, Perl, C, C++, and C#, is required. Experience in high-performance computing is a plus.

Equal Employment Opportunity

Pacific Northwest National Laboratory (PNNL) is an Affirmative Action / Equal Opportunity Employer and supports diversity in the workplace. All employment decisions are made without regard to race, color, religion, sex, national origin, age, disability, veteran status, marital or family status, sexual orientation, gender identity, or genetic information. All staff at the Pacific Northwest National Laboratory must be able to demonstrate the legal right to work in the United States.


posted 2014.10.24

Research Fellows, Post-docs and Technicians - Synthetic Biology Research Centre - University of Nottingham, UK open

Be part of one of the largest and most dynamic synthetic biology research teams in the UK.

Nottingham Synthetic Biology Research Centre (SBRC)
a BBSRC / EPSRC Synthetic Biology Research Centre 

The University of Nottingham has a strong track record in microbial synthetic biology. It has recently been awarded research funding of over £14m by BBSRC and EPSRC to further strengthen this area, to develop technologies and carry out fundamental and applied research on anaerobic and aerobic bacteria utilising waste gases including CO, CO2 and H2. A core aim of the SBRC is to generate new knowledge in a coherent, multi-disciplinary environment that ultimately leads to optimisation of production processes to generate sustainable chemicals or biofuels from microbial systems.

The SBRC has a wealth of dedicated new equipment, bespoke facilities, cohorts of PhD studentships and many existing international research and industry connections.

The SBRC's ambition is to combine expertise from a variety of disciplines including sustainable chemistry, biology and computational sciences to create optimised chassis for the sustainable production of chemicals and fuels. Our aim is to replace petrochemical derived commodity compounds, utilise waste GHG, alleviate climate change and facilitate wealth creation through the emerging waste economy.

We seek talented 'wet' and 'dry' scientists to work at research fellow, post-doctoral and technician levels to make this ambition a reality. The available posts are:

• Senior Research Associate/Fellow - Synthetic Biologist 
(level 5, 5 year term) 2 posts

To lead the biological engineering of the chosen anaerobic and aerobic chassis able to utilize 1-carbon gases. These fellows will have management responsibility over more junior staff and may be converted into a permanent academic position under the School of Life Sciences Policy for transitioning to a permanent academic position;


• Research Associate/Fellow - Synthetic Biologist 
(level 4, 3 year term) 5 posts

Post-doctoral research scientists to carry out fermentation optimisation, modification of anaerobic or aerobic microbial systems with a focus on remodelling biochemical and metabolic pathways to enable redesign of microbial systems for maximal product yield;


• Research Associate/Fellow - Responsible Research and Innovation 
(level 4, 3 year term) 1 post 

A post-doctoral social science specialist in Responsible Research and Innovation, exploring the emerging issues in synthetic biology to inform current thinking and help shape strategy and influence policy-makers as the SBRC evolves;


• Research Associate/Fellow - Bioinformatics and Synthetic Biology
(level 4, 3 year term) 1 post

A post-doctoral research scientist specialising in applied bioinformatics for synthetic biology;


• Research Associate/Fellow - Mathematical/Computational Modelling in Synthetic Biology
(level 4, 3 year term) 1 post

A post-doctoral research scientist specialising in genome scale modelling/metabolic network modelling;


• Research Associate/Fellow - Mathematical/Computational Modelling in Synthetic Biology 
(level 4, 3 year term) 1 post

A post-doctoral research scientist specialising in biochemical/synthetic biology modelling;


• Laboratory Technician 
(level 1, 5 year term) 1 post 

A technical role to provide general wet-lab microbiology and fermentation services;


• Research Technician - Fermentation 
(level 3, 5 year term) 1 post

An experienced technician to manage and provide gas fermentation and instrumentation services;


• Research Technician - Analytical Biochemistry 
(level 3, 5 year term) 1 post

An experienced technician to manage and provide analytical (GC, LC, MS) services; 


• Senior Research Technician - Biological Instrumentation 
(level 4, 5 year term) 1 post

A senior technician experienced in managing and maintaining liquid-handling robotics with line-manager responsibility for technical services in SBRC analytical services and gas fermentation. 




For further details and to make an application, please follow the hyperlinks above to the University of Nottingham Jobs page www.nottingham.ac.uk/jobs

Closing date for applications: 4th November 2014

posted 2014.10.08

Assistant Professor, Virginia Tech open

Virginia Tech has a tenure-track opening at the assistant professor level in support of its Integrated Science Curriculum (ISC) (www.science.vt.edu/ais/isc), with tenure line in the Biological Sciences Department, to start Fall 2015 at our Blacksburg, VA campus. Job requirements include a Ph.D. in biology, biochemistry, biophysics, or a closely related field; a research focus in molecular systems biology or computational cell biology; and teaching experience with a dedication to interdisciplinary education. 


The ISC, a multi-department effort including biological sciences, chemistry, geosciences, mathematics, physics, and statistics, resides within the College of Science's Academy of Integrated Science (http://www.science.vt.edu/ais). As the college's home for interdisciplinary degrees, the Academy works with academic departments campus-wide to develop and support new directions in scientific research and education. Applications from researchers whose work and goals straddle traditional academic boundaries are especially encouraged.


Further information is available at the links above; questions may be directed to Prof. John Tyson (tyson@vt.edu). Applications must be submitted online at http://listings.jobs.vt.edu (#TR0140093). Review of applications will begin on November 15, 2014. Virginia Tech is an EO/AA university. Individuals with disabilities desiring accommodation in the application process should notify Ms. Mikhelle Taylor, College of Science, (540) 231-5422, or call TTY 1-800-828-1120.

posted 2014.10.08

Postdoc position in quantitative bacterial cell biology and modeling, Yale University open

The HHMI laboratory of Dr. Jacobs-Wagner at the Microbial Sciences Institute at Yale University has a postdoctoral position for a physicist or computational biologist interested in leveraging his or her quantitative skills to address important questions in the emerging area of bacterial cell biology. Our lab uses a multidisciplinary approach that combines quantitative microscopy with genetics, biochemistry, biophysics and modeling to study the spatial and temporal mechanisms involved in bacterial multiplication. We are particularly interested in candidates with a strong background in quantitative analysis and modeling. Experience in single-cell fluorescence microscopy, bacterial genetics or MATLAB is a plus. 

Information about our lab and publications can be found at http://www.yale.edu/jacobswagner/

To apply, please send a CV, cover letter and contact information for three professional references to Dr. Christine Jacobs-Wagner (christine.jacobs-wagner @ yale.edu).

posted 2014.09.29

Postdoctoral position in Systems Biology in the NYC open

A postdoctoral position is available at the Albert Einstein College of Medicine (NYC) to study the systems-level dynamics of the vertebrate segmentation clock by using zebrafish as the model organism. 
Interested candidates must have a PhD and have a strong record of accomplishment and experience in mathematical modeling and computational biology. 

The applicants must have proficiency in English, at least one first author publication in a reputed international journal from their Ph.D. work, enthusiasm in pursuing research in systems developmental biology. We are looking for a colleague who is collegial, highly motivated, and independent. 

Salary support will be based on research experience and accomplishments. 

Please send applications, which should include a cover letter detailing your past research accomplishments and future research goals, a full CV (with bibliography) by email to: 
Ertugrul Ozbudak Department of Genetics Albert Einstein College of Medicine Email: ertugrul.ozbudak @ einstein.yu.edu

posted 2014.09.25

Yale University - Microbial biophysics open

The multidisciplinary MICROBIAL SCIENCES INSTITUTE, a cornerstone of Yale's new West Campus research enterprise, invites applications for a tenure-track position at the ASSISTANT PROFESSOR level to commence 1 July 2015. The position will have a primary appointment in the Department of MOLECULAR BIOPHYSICS AND BIOCHEMISTRY within the Faculty of Arts and Sciences. We seek candidates with a strong background in quantitative microbiology, working at the interface of physics and biology. Candidates must have a Ph.D. or equivalent degree in physics, engineering, mathematics or biology and a record of outstanding research that demonstrates originality in addressing significant questions in the broad area of microbial sciences. We expect that the successful candidate will establish an active research group, be an interactive member of the faculty, participate in interdisciplinary research and training, and engage in regular graduate and undergraduate teaching. Communication skills conducive to excellence in teaching at both the undergraduate and graduate levels are necessary.

We seek applications from candidates studying any microbes (viruses, bacteria, archaea or eukaryotic microorganisms), and using any experimental or computational approach. 

Applicants should create a profile at https://academicjobsonline.org/ajo/jobs/4517 and upload a statement of research plans (2-3 pages), curriculum vitae, and up to five reprints of published work(s). Applicants should also arrange for three references to upload their letters of recommendation. The review of applications will begin on 15 October 2014 and will continue until the position is filled. For further information, contact Kelly Locke at kelly.locke at yale.edu or Microbial Sciences Institute P.O. Box 27389 West Haven, CT 06516-7390. 

Yale University is an affirmative action, equal opportunity employer. Yale values diversity among its faculty, students, and staff and strongly encourages applications from women, persons with disabilities, underrepresented minorities and protected veterans.

posted 2014.09.24

Assistant Professor in Quantitative Biology open

The Department of Biological Sciences at the University of Alaska Anchorage invites applications for a tenure track faculty position in Quantitative Biology. We are broadly interested in recruiting a candidate working at the nexus of biology and statistics/mathematics, who uses quantitative experimental, computational, and/or mathematical methods, and who will develop an active research program within the department and university community. 

Areas of interest include statistical analysis of large data sets, mathematical models of complex biological phenomena, systems biology, cell biology, population genomics and/or molecular evolution, advanced biostatistical approaches to organismal biology, population ecology, and/or behavior. 

The successful candidate is expected to contribute to the undergraduate and graduate teaching missions of the Department through offering biostatistics courses, teaching advanced classes in their area of expertise, and training graduate students. Candidates will be expected to enhance the research mission of the department through the development of an active, externally funded research program. 

The ideal candidate will have a passion for student learning, evidenced by a record of, or potential for, excellence in teaching, and a commensurate record of significant contributions to quantitative biological research. Interest in collaborative research opportunities within and outside the Department of Biological Sciences is a plus. 

Faculty in the Department of Biological Sciences participate in NSF EPSCoR and NEON, NIH INBRE, and other cross-cutting research programs within and outside the University of Alaska, and closely interact with colleagues from numerous state and federal health, land, wildlife, and fisheries management agencies. Faculty websites detailing current research interests can be found at www.uaa.alaska.edu/ biology 

The University of Alaska Anchorage (UAA) is the largest of three universities in the University of Alaska system, serving nearly 20,000 students. Anchorage, the largest city in Alaska, with an ethnically diverse population of 290,000, offers a lively intellectual and cultural life, including opera, symphony, theater, art events, and a variety of restaurants. Set between snow-capped peaks of the Chugach Mountains and the ocean waters of Cook Inlet, the city offers ready access to state and national forests and parks, year-round outdoor recreation, and unsurpassed natural beauty. 

The Department seeks a candidate dedicated to equity and diversity of the campus community and to promoting an environment that increases student knowledge about local, national, and global communities. UAA is an AA/EO Employer and Educational Institution. Applicant must be eligible for employment under the immigration Reform and Control Act of 1986 and subsequent amendments. Your application for employment with UAA is subject to public disclosure under the Alaska Public Records Act. 

Interested persons should apply by submit a cover letter, curriculum vitae including recent publications, a statement of research accomplishments and future plans, a description of teaching experience and philosophy, and three letters of reference by applying to the University of Alaska Anchorage online at uakjobs.com.

posted 2014.09.01

POSTDOCTORAL POSITIONS IN BIOINFORMATICS AND COMPUTATIONAL BIOLOGY open

UConn Health is engaged in a major expansion of its research programs in computational biology, bioinformatics, and systems biology, as part of several transformative state initiatives. The Bioscience Connecticut initiative, totaling approximately $1B, includes the establishment of the new Center for Quantitative Medicine in 2013. 
  
The Center for Quantitative Medicine is recruiting several postdoctoral fellows to pursue research in bioinformatics and computational systems biology with a particular focus on algorithm development and computational modeling of cellular processes, as well as applications of quantitative methods to biomedicine. Positions are available in the Laubenbacher, Mendes, and Vera-Licona research groups. The Laubenbacher group has ongoing projects in the development and implementation of algorithms related to modeling and simulation, with applications to cancer and infectious diseases related to iron metabolism. A particular focus is on immunological aspects of these and other diseases. Vera-Licona works on algorithm and software development for the modeling and simulation of biological systems. She is looking for a postdoc to work on the development of computational tools for identification of cascading failures and in silico combination therapies in complex biological networks. Mendes studies computational methods in systems biology, including development of simulation software, and is seeking a postdoctoral researcher to work on creating models of iron biochemistry, which is associated with several diseases such as cardiovascular, cancer, neurodegenerative, and many others. There are many collaborative activities between the three research groups. For more information about the CQM, please visit our website at http://cqm.uchc.edu/ 

The successful candidates will be expected to pursue research in the areas described above, with activities including interacting with experimental collaborators, setting up models, data analysis workflows, and other computational procedures, writing up and publishing results in peer-reviewed journals, presenting results at conferences and helping with developing new projects. The successful candidates will be individuals with background in mathematics, computer science, or physics with some knowledge of biology, or biologists with experience in developing computational/mathematical models. All of these positions will be pursuing interdisciplinary work at the boundaries of these disciplines. 

To apply, please send your CV, a brief statement of research interests, and contact information for three references to Kathy Black at kblack @ uchc.edu 

The University of Connecticut is an Affirmative Action/Equal Employment Opportunity employer, M/F/M/PwD/PV

posted 2014.08.27

Postdoctoral Position in Computational Biology open

A postdoctoral position is available immediately for NIH funded projects at the Das Lab at the Battelle Center for Mathematical Medicine at The Research Institute at Nationwide Children's Hospital (www.nationwidechildrens.org/research). We are seeking for outstanding candidates who are interested in applying computational/mathematical methods to solve cutting edge problems in biology. The fellow is expected to work closely with our experimental collaborators and develop and analyze models for two different projects: (i) Single cell activation kinetics in immune cells. (ii) Spatio-temporal kinetics of host-pathogen kinetics in middle ear infections. Highly motivated and career oriented applicants with expertise in statistical physics, inference methods, stochastic methods, and evolutionary dynamics are particularly encouraged to apply. No previous background in biology is required however the fellow is expected to be interested in learning the relevant biology and communicate with our collaborators. The fellow is also required to know programming in Fortran/C/C++ and Perl/Python. The position is available initially for one year and can be potentially extended up to three years. More details about the lab can be found at, http://openwetware.org/wiki/User:Jayajit_Das

We have a state of the art computer cluster over 120 INTEL processors. The resources at the Ohio State University campus and Ohio Supercomputer Center are also available. The position will be for one year, renewable up to three years. Interested candidates should send (preferably by email), a brief cover letter stating your interest in our lab, a short CV and names and contact information of three referees to, 

Jayajit Das
Assistant Professor
Battelle Center for Mathematical Medicine, 
The Research Institute at Nationwide Children's Hospital and Departments of Pediatrics and Physics, Ohio State University, 
Columbus, OH 43206 Email: das.70 @ osu.edu Ph: 614-355-5632 Fax: 614-355-2928 
Please send a copy of the application to: Ms. Rhonda Purcell Admin. Assistant Phone # 614-355-6680 Email: Rhonda.Purcell @ nationwidechildrens.org

posted 2014.08.15

Postdoctoral position in Bacterial Evolutionary Genomics open

University Hospital of Lausanne (CHUV), Switzerland We are seeking an independent, highly motivated postdoctoral researcher to work on the microevolution and transmission dynamics of Methicillin-Resistant Staphylococcus aureus (MRSA). The project will utilise next-generation sequencing of a large strain collection, combined with state-of-the art bioinformatics techniques, to examine the emergence and spread of a MRSA clone at multiple scales; within a single health care setting, regionally and internationally. The analysis will also exploit detailed epidemiological informationon patient movements.The successful candidate will have a proven track record in comparative genomics, molecular epidemiology, and. experience with computational/bioinformatics tools. A background in mathematical modelling would also be advantageous. 

The research group is headed by P.D. Dominique Blanc and is in the service of hospital preventive medicine, with strong interaction with the Institute of Microbiology of Lausanne. The research interests of our group concern the molecular epidemiology of hospital acquired infections, with a special interest in MRSA. 

The candidates should have a good knowledge of English. French is helpful but not necessary. The salary is generous and is set according to the University of Lausanne. The start date will October 1, 2014, or by mutual arrangement, for a 2-year period. 

To apply, please send a single pdf containing your application letter, CV and the names of two or three references to: Dominique.Blanc @ chuv.ch

posted 2014.07.12

Senior Scientist Systems Biology open

We are the world's leading chemical company because we offer intelligent solutions for our customers and for a sustainable future. We link and develop people with diverse talents all over the world. For you, this means a variety of ways to advance. Not only your performance but also your personality matter to us. At BASF, careers develop from opportunities. 

BASF Plant Science develops plant biotechnology solutions to increase the yield and quality of crop plants. CropDesign, the Belgian division of BASF Plant Science, focuses on rice as model crop. The company applies genomics, informatics and robotics technologies and employs about 150 employees in state-of-the-art laboratories and an automated greenhouse complex. www.cropdesign.com  

What you can expect: 
As Senior Scientist Systems Biology you will be part of an international team of scientists. In this team you will be an expert in the mining and interpretation of experimental data derived from multiple -omics platforms. You will drive the development of innovative systems biology data analysis methods. You will write and present reports to colleagues in Belgium, Germany and the US. As an experienced scientist, you will participate in collaborations with academia. 

What we expect: 
You have a PhD in Systems Biology, Bioinformatics, Computational Biology or Plant Molecular Biology. You are an expert in the mining and interpretation of plant biological data. You have experience with the analysis of biological networks. You combine your knowledge of the design and analysis of research experiments with hands-on experience with bioinformatic tools and databases. You are entrepreneurial and you enjoy working in a multidisciplinary international team. 

We offer: 
research environment. On-the-job training as part of a committed team. Competitive compensation including attractive benefits as well as excellent career opportunities in an international company 
Expect to be surprised by the exciting range of career opportunities at BASF. 

Working area: Research & Development 
Location: CropDesign N.V., Zwijnaarde 
Working hours: Full-time 
Contract Type: Permanent 

Reference code EN54244041_ONLE_1 
Please apply online at www.basf.be/career or in writing to BASF Belgium Drève Richelle 161E/F 1410 Waterloo 
For more information please contact: Tel.: 00800 33 0000 33 +32 (0)2 373 2222 E-Mail: jobs@basf.com

posted 2014.07.08

Scientist Systems Biology open

We are the world's leading chemical company because we offer intelligent solutions for our customers and for a sustainable future. We link and develop people with diverse talents all over the world. For you, this means a variety of ways to advance. Not only your performance but also your personality matter to us. At BASF, careers develop from opportunities. 

BASF Plant Science develops plant biotechnology solutions to increase the yield and quality of crop plants. CropDesign, the Belgian division of BASF Plant Science, focuses on rice as model crop. The company applies genomics, informatics and robotics technologies and employs about 150 employees in state-of-the-art laboratories and an automated greenhouse complex. www.cropdesign.com 

What you can expect: 
As Scientist Systems Biology you will analyze and model experimental data that are derived from various -omics platforms. You will take part in the development of innovative data mining and modeling methods. As part of an international team of scientists you will write and present reports to colleagues in Belgium, Germany and the US. You will participate in collaborations with academic groups. 

What we expect: 
You are an expert in machine learning and modeling techniques. You can integrate data from various levels of biology (e.g. phenomic, transcriptomic or genomic data) via computational and statistical means. You have a PhD in Systems Biology, Bioinformatics or Computational Biology. You combine your knowledge of the design and analysis of research experiments with hands-on experience with statistical and bioinformatic tools. You enjoy working in a multidisciplinary international team. 

We offer: 
Responsibility from day one in a cutting-edge research environment. On-the-job training as part of a committed team. Competitive compensation including attractive benefits as well as excellent career opportunities in an international company. Expect to be surprised by the exciting range of career opportunities at BASF. 

Working area: Research & Development 
Location: CropDesign N.V., Zwijnaarde 
Working hours: Full-time 
Contract Type: Permanent 
Reference code EN54244073_ONLE_1 

Please apply online at www.basf.be/career or in writing to BASF Belgium Drève Richelle 161E/F 1410 Waterloo 
For more information please contact: Tel.: 00800 33 0000 33 +32 (0)2 373 2222 E-Mail: jobs@basf.com

posted 2014.07.08

Postdoctoral Position in Statistical Systems Biology open

A postdoctoral position in statistical systems biology is available in the Department of Biostatistics and Computational Biology at the University of Rochester Medical Center under the supervision of Dr. Matthew McCall.  The postdoctoral fellow will work as part of a collaborative team of Biostatisticians and Biomedical Geneticists seeking to understand the complex regulatory networks that govern cellular function.  This group currently focuses primarily on the changes in gene regulatory networks brought about by malignant transformation.  A key element of this ongoing research is the development of new statistical and computational methodology and the application of these methods to cutting-edge research in systems biology and genetics.

The successful applicant should have recently completed a PhD and have training in biostatistics, bioinformatics, computational biology, or a related field.  Candidates with a background in the biological sciences and strong quantitative skills are also encouraged to apply. Experience with statistical programming in R is desirable. The ideal candidate will have or be willing to obtain a familiarity with network modeling methodology.  Preference will be given to candidates that demonstrate a desire to work in a collaborative multi-disciplinary environment.

This position is initially available for one year with the possibility of renewal based on performance, availability of funds for salary support and a mutual desire to continue the appointment.  The start date for this position is September 1st, 2014 or shortly thereafter. The initial salary commensurate with experience is $45,000 - $50,000 plus benefits.  Interested applicants should email a PDF containing their CV and contact information for three references to:

Matthew N. McCall, Ph.D.
Department of Biostatistics and Computational Biology
University of Rochester Medical Center
Email: Matthew_Mccall@urmc.rochester.edu
Website: http://mnmccall.com


The University of Rochester is an Affirmative Action, Equal Opportunity institution.
Applications from women and under-represented minorities are particularly encouraged.

posted 2014.06.27

PhD Studentship in Computational Biology open

PhD Studentship in Computational Biology
Department of Bioengineering, Imperial College London

"Mathematical modelling of multi-scale control mechanisms for skin barrier homeostasis "

We invite applications for a PhD studentship in the Department of Bioengineering at Imperial College London. A stipend and home/EU fees for 3 years will be awarded to the successful candidate. Overseas applicants can apply but have to show the evidence that the difference between the overseas fees and home/EU fees can be covered by other funding.

This project aims to identify fundamental regulatory mechanisms of skin barrier homeostasis, which is the result of regulations across different spatio-temporal scales, including differentiation, cornification, protein interactions and gene regulation. The PhD student will develop mathematical tools and frameworks, based on deep understanding of biology behind combined with systems and control perspective, to provide a unified and practically applicable mechanistic model to elucidate how the deregulation of the mechanisms leads to skin disease such as atopic dermatitis.

More information on research activities in Dr Tanaka's group on biological control is found inhttp://www.bg.ic.ac.uk/research/r.tanaka.

Applicants should have a high calibre Masters degree (or equivalent qualification) in a relevant area to undertake the mathematical modelling part of this project. Strong biological background is desired. Experience in modelling and analysis of biological systems and expertise in modelling with differential equations and numerical methods are preferable. We look for highly motivated applicants with excellent interpersonal, written and oral communication skills and enthusiasm for exposure to a diversity of scientific projects. The PhD will involve close interactions with biological collaborators.

For further details of the post contact Dr Reiko Tanaka (r.tanaka@imperial.ac.uk). Interested applicants should send a current curriculum vitae and research statement to Dr Tanaka by e-mail.

Closing date: Applications are dealt on a rolling basis until the position is filled

Start date: As soon as possible or latest December 2014

posted 2014.06.14

Call for expressions of interest open

Call for expressions of interest


The Computational & Systems Biology Group (https://sites.google.com/site/csbgcnc/) at the Center for Neuroscience and Cell Biology (CNC, http://www.cnbc.pt) - The University of Coimbra (Portugal) welcomes expressions of interest from highly motivated researchers of any nationality seeking to conduct internationally competitive fundamental research with translational potential in the areas of computational biology or biology-oriented computational chemistry. Researchers with a strong publication record in any of the following areas are especially encouraged to apply:

  • Reaction-diffusion systems

  • QSAR

  • Physiological modeling of the vascular system

  • Sequence and phylogenetic analysis


Candidates must have obtained a Ph.D. degree in last 3-8 years and show an outstanding curriculum and publication record. Applicants must send the following documents to salvador@cnc.uc.pt no later than May 11, 2014

  • Motivation letter highlighting main research accomplishments to date and motivation for applying for this position

  • CV and publications list highlighting the two research papers that researcher finds most representative of the scientific quality of his/her work, and describing her/his contributions for the work.

  • Outline of research program to be conducted over a 5 year period at CNC


CNC will strongly support the application of selected  candidates to the upcoming 2014 call for "Investigator FCT" grants (http://www.fct.pt/apoios/contratacaodoutorados/investigador-fct/2014/index.phtml.en, http://www.fct.pt/apoios/contratacaodoutorados/investigador-fct/2014/docs/Highlights_IF2014.pdf). Pending on the selected candidate securing an Investigator FCT 5-year grant, CNC will host him/her at the new UC-Biotech facility. The researcher will be initially integrated in the Computational & Systems Biology Group, and will be encouraged to start an independent group once s/he secures independent research funding.

posted 2014.04.25

Postdoctoral research associate position at the University of Virginia open

Physical Modeling and Computational Methods Development for the Study of 
Transcription Factor-DNA Binding Dynamics In Vivo 

The ongoing genomics revolution is transforming molecular biology research into a scientific discipline with a strong mathematical/computational branch. The demand for computational/systems biologists remains high and represents a fantastic career opportunity for those trained in quantitative areas including physics, chemistry, statistics, mathematics and computer science. This research associate position represents a great opportunity for a PhD in physics, chemistry, biomedical engineering or chemical engineering to work on challenging physical modeling problems applying chemical reaction rate theory (deterministic and stochastic) while developing new skills in the analysis of functional genomic data (skills that are in high demand). 

The Bekiranov lab at the University of Virginia is seeking applicants for a postdoctoral research associate position to extend (to the whole genome) a recently published method (Science 342: 369-72), which determines the dynamics of proteins (transcription factors) that switch genes on and off by binding to DNA. In addition, the candidate will help develop a physical model of and extract dynamic parameters from another experimental approach, which also measures transcription factor-DNA binding dynamics. These studies will yield parameters and methods that enable rigorous physical/mathematical modeling of the complex molecular process of transcription.

Requirements: 
* PhD in physics, biophysics, physical chemistry, biomedical engineering, chemical engineering or other related fields with formal training in physical/mathematical modeling of molecular systems. Candidates with extensive experience and a publication track record of mathematical modeling of the dynamics (deterministic and/or stochastic) of chemical reactions or molecular systems are highly encouraged to apply. 
* Minimum of 2-3 years experience programming in Mathematica, MATLAB or R with a strong background in UNIX is required. In addition, experience with a scripting language including Python, Perl, Java, etc is also highly desirable. Importantly, the position will involve extensive mathematical modeling and programming, so the candidate must have experience and interest in both.
* Experience with non-linear regression analysis. Some background with statistical data analysis is also highly desirable.
* Strong publication record and demonstrated scientific track record.
* Knowledge of molecular biology concepts is also highly desirable but not required.

Application Instructions:
To apply for this position, visit https://jobs.virginia.edu and search on Posting Number 0613969. 
Complete a Candidate Profile online, attach a cover letter, curriculum vitae and information for three references. 

The position will remain open until filled. 

For additional information regarding the application process, please contact Helen Norfleet-
Shiflett, via email hn6u@virginia.edu or telephone (434) 924-1667. 

The University of Virginia is an affirmative action/equal opportunity employer committed to diversity, equity, and inclusiveness.

posted 2014.04.18

Specialist, ETL and Application Developer open

Job tile:
Specialist, ETL and Application Developer

Starting March 1st 2014
Duration 18 months 

General Summary 
Installs, configures and loads clinical data into tranSMART in support of the Phelan- McDermid Syndrome Data Network at the Center of Biomedical Informatics, Harvard Medical School. The open source tranSMART platform is an i2b2 based research environment providing researchers a single self-service web portal with access to phenotypic, 'omics, and unstructured text-based data from multiple internal and external sources, combined with search and analysis capabilities. The goal of the Phelan-McDermid Syndrome Data Network is to collect all available medical and research data from individuals diagnosed with Phelan-McDermid Syndrome to make meaningful, well-annotated clinical data available to researchers and to share insights with members of the PCORI network. This will help researchers to mine much more meaningful information for future studies of those diagnosed with Phelan-McDermid Syndrome. This short video presents our work using tranSMART on an Autism pilot. 

Duties Notice
The statements below describe the essential duties of the person assigned to this job. They are not intended as an exhaustive list of all job duties and responsibilities. 

Principal Duties and Responsibilities 
  1. Installs tranSMART and configures it to utilize an Oracle database. 
  2. Develops loading programs and procedures to handle data from different clinical and computational sources. Data will be loaded into the existing tranSMART schema. 
  3. If it requires, extends the existing tranSMART schema to handle new data formats. 
  4. Installs PopMedNet™ software 
  5. Configure the interface between i2b2/tranSMART and PopMedNet™ 
  6. Works closely with researchers to understand data derived from both healthcare providers and computational methods. 
  7. Works independently and self-manages different aspects of the project lifecycle. 
  8. May assist team members in database administration, maintenance, and preparing reports. 
  9. Documents any software written to inform end users of its functionality, and developers for support purposes. 

Minimum Knowledge and Skills Required 
  1. Work requires the knowledge of theories, principles, and concepts typically acquired through completion of a Bachelor's degree in Computer Science and/or Biomedical Informatics or a closely related field and three to four years of experience. 
  2. Work requires knowledge biomedical terminologies and ontologies. 
  3. Work requires a strong knowledge of Oracle database design and development. 
  4. Work requires knowledge of Java, Perl and Pentaho Data Integration (Kettle). 
  5. Work requires the analytical skills to collect information from diverse sources, apply professional principles in performing various analyses, and summarize the data in order to solve problems. 
  6. Work requires the ability to communicate effectively both orally and in writing. 
  7. Work requires the ability to manage projects in a self-starting, nearly autonomous fashion.    
  8. Works requires the ability to work well on a team, communicating effectively and supporting team members as needed. 
  9. Work requires that incumbent works on-site for most or all of the workweek, being available for frequent in-person meetings. 
  10. Work requires the ability to interact with outside collaborators, providing prompt and professional service, support and communication. 

For additional information contact: 
Paul Avillach, MD, PhD 
Harvard Medical School 
Center for Biomedical Informatics 
10 Shattuck Street Boston, MA 02115 
paul_avillach @ hms.harvard.edu

posted 2014.03.01

Postdoc position in single cell systems biology (CyTOF) open

Postdoc position in single cell systems biology (CyTOF)

The position:
A position is available for a postdoctoral fellow interested in the systems biology of tumor-associated immune cells (TAICs) and their role in the progression of cancer. The selected candidate will use mass cytometry (CyTOF) data to generate and refine signaling network models to describe TAIC plasticity. Our ultimate goal is to predict and validate network modulations that control TAIC plasticity. The candidate will perform experiments AND drive the development of the systems biology network model. The postdoctoral fellow will be located at the University of Zurich and will interact with Roche research groups. This project is supported by SystemsX, the Swiss Initiative in Systems Biology for 2 years with the option to extend for a third year.

The successful candidate will:

  • Systematically modulate and reprogram TAICs to change their functional state at the bench
  • Become proficient in mass cytometry (CyTOF), a recently developed high-capacity single-cell proteomics technology
  • Use mass cytometry data to generate network models to predict in silico optimal modulation strategies
  • Experimentally validate predictions to discover potential new targets for therapeutic intervention
  • Aim for results relevant for human health, publishable in highly visible journals

Apply by:
Send a cover letter (including an explanation of your motivation), CV, and at least two references to Prof. B. Bodenmiller to  bernd.bodenmiller@imls.uzh.ch
Prof. Bernd Bodenmiller, Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. http://www.imls.uzh.ch/research/bodenmiller.html...

posted 2014.03.01

9 open doctoral researcher fellowships in Jena open

The Jena School for Microbial Communication (JSMC) is funded by the German Excellence Initiative. JSMC is an ambitious Graduate School with over 150 PhD students who are educated in a structured, interdisciplinary training program based on top-level fundamental research. It conceptionally combines different research areas to a comprehensive picture of microbial communication (www.jsmc.uni-jena.de). Institutes at five faculties of the Friedrich Schiller University Jena, six non- university research institutes as well as 12 partner companies are participating in this cutting-edge research and training program. 

The Graduate School of Excellence 'JSMC' invites applications for 
9 Doctoral Researcher Positions (TV-L E13, 65%) 
Research projects on several topics in Natural and Life Sciences 

We expect: 
  • a Master's degree (or equivalent) in Natural or Life Sciences (e.g., Biology, Chemistry, Bioinformatics, Geosciences, Biomedical Sciences, Biotechnology, etc.). Candidates about to obtain their degree are welcome to apply 
  • high motivation and interest in joining one of the interdisciplinary research areas of the JSMC   
  • creativity and interest in shaping your own thesis project 
  •  an integrative and cooperative personality with enthusiasm for actively participating in the lively JSMC Community 
  •  very good communication skills in English (the language of instruction at the JSMC) 

We offer: 
  •  a highly communicative atmosphere within a scientific network providing top-level research facilities 
  • a doctoral researcher position (TV-L E13, 65%) funded for three years based on the regulations of the DFG (German Research Foundation) as well as generous research funding 
  • a comprehensive mentoring program with supervision by a team of advisors 
  • a top-level PhD training program with courses in state-of-the-art research technologies and soft skills 
  • Jena - the German City of Science 2008: a young and lively town with dynamic business activities, successful scientific centers of innovation and a vibrant cultural scene around the famous 

Friedrich Schiller University Friedrich Schiller University Jena is an equal opportunity employer. We also welcome applications from disabled persons. 
The application procedure takes place exclusively online via the Online Application Portal on the JSMC website: 
Please acquaint yourself with the open PhD projects and the application process described on this website. www.jsmc.uni-jena.de
Selected applicants will be invited to the JSMC Recruitment Meeting in Jena, Germany, on June 16-18, 2014. Awarding decisions will be made shortly thereafter, allowing the projects to start immediately. 
Application deadline: March 31st www.jsmc.uni-jena.de , 2014 (12pm, CET) 


PhD Research Projects / JSMC Recruitment Call 2014/1 
Project details available at: www.jsmc.uni-jena.de/phd-program/fellowship-application/vacant-projects/ http://www.jsmc.uni-jena.de/phd-program/fellowship-application/vacant-projects/

posted 2014.02.25

Post-doctoral researcher job opening: Systems Biology of Infectious Diseases open

Global Health Department & Center for Drug Discovery and Innovation University of South Florida, Tampa bay area, FL USA 

Post-doctoral researcher job opening #3476 
Systems Biology of Infectious Diseases 

The Systems Biology of Infectious Diseases laboratory, as part of the Department of Global Health (GH) and the Center for Drug Discovery and Innovation (CDDI), University of South Florida (USF), is searching for postdoctoral researchers in the field of infectious diseases. 

He/She is part of an interdisciplinary program focusing on human hepatocyte- malaria interaction. The suitable candidate will use innovative approaches to answer infectious disease questions involving genetics, metabolomics, transcriptomics, genomics and epigenomics. The project will be on computational set up of liver infectious disease systems including computational analysis, integration and modeling of large-scale data sets. The incumbent will attend conferences, participate on submission of grant applications, write scientific papers based on research findings, assist with the oversight of graduate laboratory students and other duties as assigned. 

Minimum Qualifications: Applicant must have a Ph.D. or equivalent degree in one of the following areas: computational biology, bioinformatics, statistical genetics, and systems biology. Applicant should have experience working with large biological data sets such as Next Generation Sequencing (NGS) data sets. 

Preferred Qualifications: Preferred applicants will be proficient in UNIX environment; and fluent in at least one programming language: C++, Java, Perl or Python and have demonstrated a record of academic and research achievements. 

Applicant must be highly motivated, able to think independently and work as part of an integrated multidisciplinary research team. Interested candidates should submit a curriculum vitae, brief research overview and contact of references to Dr Rays Jiang (jiang2 @ health.usf.edu) 

Additional information 

The position will be in the Integrative Research Building, a new research center with diverse sets of expertise from computational biology, molecular biology to chemical biology. 

The university is located in Tampa, part of the great metropolitan area of Tampa bay. The city offers year around sunshine on the gulf coast, with a vibrant culture and numerous beautiful state parks close by.

posted 2014.02.03

3-year PhD Studentship in Imperial College London open

"Mathematical modelling of multi-scale control mechanisms for skin barrier homeostasis "

We invite applications for a PhD studentship in the Department of Bioengineering at Imperial College London. A stipend and home/EU fees for 3 years will be awarded to the successful candidate. Overseas applicants can apply but have to show the evidence that the difference between the overseas fees and home/EU fees can be covered by other funding.

This project aims to identify fundamental regulatory mechanisms of skin barrier homeostasis, which is the result of regulations across different spatio-temporal scales, including differentiation, cornification, protein interactions and gene regulation. The PhD student will develop mathematical tools and frameworks, based on deep understanding of biology behind combined with systems and control perspective, to provide a unified and practically applicable model to elucidate how the deregulation of the mechanisms leads to skin disease such as atopic dermatitis. This is a collaborative project with RIKEN IMS Centre for Integrative Medical Sciences.

ore information on research activities in Dr Tanaka's group on biological control is found in http://www.bg.ic.ac.uk/research/r.tanaka.

Applicants should have a high calibre Masters degree (or equivalent qualification) in a relevant area to undertake the mathematical modelling part of this project. Strong biological background is required. Experience in modelling and analysis of biological systems and expertise in modelling with differential equations and numerical methods are preferable. We look for highly motivated applicants with excellent interpersonal, written and oral communication skills and enthusiasm for exposure to a diversity of scientific projects. The PhD will involve close interactions with biological collaborators.

For further details of the post contact Dr Reiko Tanaka (r.tanaka@imperial.ac.uk). Interested applicants should send a current curriculum vitae and research statement to Dr Tanaka by e-mail.

Closing date: 1st March 2014

Start date: October 2014

posted 2014.01.23

A postdoctoral position is available in Computational Biology open

A postdoctoral position is available in Computational Biology in the Department of Mathematics, Ryerson University (http://www.math.ryerson.ca), Toronto, Canada.  This position provides an opportunity to engage in research in Applied Mathematics, with a limited amount of teaching. The salary is competitive, with funding provided for one year.  


We are seeking qualified and motivated applicants in Applied Mathematics, to work on interdisciplinary projects aimed at developing stochastic modelling and simulation tools for studying biological systems. The ideal candidate would have a strong background in Applied Mathematics (Numerical Analysis and Probability) and/or Computer Science. Strong programming skills in Matlab are mandatory. Experience with dynamical systems is expected. In addition, knowledge of biological/chemical reaction modelling and stochastic simulation is considered an asset.


The fellowship is open to candidates of any nationality and selection will be based upon the candidate's research potential and teaching ability. Ideally the job will begin as early as May 1, 2014, however there is some flexibility in the starting date. The research will be led jointly by Dr. Silvana Ilie and Dr. Katrin Rohlf.


The screening process will start on February 17, 2014, and continue until the position is filled.  Applicants should submit a curriculum vitae and three letters of recommendation. At least one of these letters should report on the candidate's teaching abilities. Application material and reference letters should be sent directly by e-mail to compbio@ryerson.ca  


We appreciate all replies to this advertisement, but only applicants under consideration will be contacted. Ryerson University has an Employment Equity Program and encourages applications from all qualified candidates, including aboriginal peoples, persons with disabilities, members of visible minorities, and women. 

posted 2014.01.20