Home > Jobs > 2015 > Postdoctoral fellow - University of North Carolina, USA


Postdoctoral fellow - University of North Carolina, USA open

We are seeking one or more postdoctoral fellows to develop computational models and/or conduct live cell imaging analysis. The goal of the project is to study the role of noise in cellular signal transduction pathways (via G protein coupled receptors and MAPKs) and cell fate transitions.

This NIH-funded project is a collaborative effort between the labs of Drs. Timothy Elston, Henrik Dohlman and Beverly Errede.

Project details: All intracellular processes are subject to large amounts of molecular-level fluctuations.  In certain contexts, this "noise" may serve as a bet-hedging mechanism to diversify the response of a population of otherwise identical cells, whereas in other contexts noise suppression may be required to properly coordinate response pathways when cells are faced with multiple competing stimuli. The yeast Saccharomyces cerevisiae is the premier model system for studying mechanisms of noise regulation. Planned investigations will combine microfluidic devices and fluorescent imaging to follow single cells in well controlled environments, quantitative image analysis to characterize fluctuations in signaling and gene expression, and stochastic modeling to suggest and test noise regulation mechanisms.

The successful candidate will have a PhD in computational biology, biophysics, physics, applied mathematics, biochemistry, cell biology, or a related field, a proven track record of research productivity, and enjoy participating in interdisciplinary team science.

The University of North Carolina is the oldest public university in the nation, and constently ranked in the top ten for NIH funding. The city of Chapel Hill is a vibrant community with excellent public schools and low cost of living.

Lab websites:

Elston: http://www.med.unc.edu/pharm/elstonlab/index.html

Dohlman: http://www.med.unc.edu/~hdohlman/research.html

Errede: http://www.med.unc.edu/biochem/errede

To apply write directly to Dr. Elston at: timothy_elston @ med.unc.edu

posted 2015.05.29