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Postdoctoral Position in "Dynamical Systems Biology" at the University of Lille, France. closed


"Topic: Nonlinear dynamics study of stress-induced cell death decisions."

A challenge in biology is to understand the design principles of complex biochemical networks that are required to execute sophisticated regulatory functions in the cell. A theoretical framework to study this issue consists in comprehensively investigating the dynamical properties of small biochemical circuits combining a few elemental feedforward and feedback loop! motifs.

Our team is investigating, computationally and experimentally, the stress-induced cellular response - adaptation or death - depending on the type, intensity and duration of the stress. The adaptation process relies on negative feedback or incoherent feedforward loops while the death decision relies on positive feedback loops. In addition, cellular response shows significant cell-to-cell variability. These features motivate us to investigate the nonlinear and stochastic dynamics of minimal biochemical circuits that combine these motifs.

This theoretical project requires to perform extensive dynamical system analysis of a broad class of low-dimensional differential equation biochemical models, by using and combining various approaches (linear stability, bifurcation, phase-space, control theory and stochastic approaches). This project is closely related with other experimental and systems-bi! ology projects in our team.

The candidate should have (i) a strong background in applied mathematics or physics, especially in the field of nonlinear dynamical systems; (ii) some interest for biology.

The position is for one year renewable, and would start anytime in the first semester of 2017. Net annual salary is about 28000€ and includes a benefits package (health insurance, retirement and unemployment benefits). The laboratory (http://www.phlam.univ-lille1.fr/) is located on the Villeneuve d'Ascq campus of the University of Lille. Lille is a lively city connected by highspeed train to Brussel (30mn), Paris (1h) and London (1h30). Applicants should send a letter of motivation, a CV including a complete list of publication and at least 2 letters of recommendation to: quentin.thommen@univ-lille1.fr and Benjamin.pfeuty@univ-lille1.fr

For more informations: http://www.phlam.univ-lille1.fr/spip.php?article1066

posted 2017.01.08