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2019

PhD student in BioComputing, University of Lille open

We are looking for a PhD student to work in the BioComputing group (University of Lille) on formal methods (especially inspired by logic and semantics of programming languages) for modeling and static analysis of biological systems. More precisely, the thesis entitled "Computational Models of Intestinal Glucose Absorption for Diabetes Prediction", aims at developing new computational methods for the prediction of glucose intestinal absorption at the physiological and cellular level in order to improve the understanding of diabetes pathology. In addition of having a background in formal methods, we expect candidates interested in health sciences and biology. For more details, see

The thesis will be co-supervised by Cédric Lhoussaine and François Pattou (Professor of Surgery). 
The starting date will be September or October 2019.
Potential candidates are encouraged to contact Cedric Lhoussaine (Cedric.Lhoussaine@univ-lille.fr) as early as possible. 
The deadline for application is 1st of May.

posted 2019.03.01

Research Associate/Senior Research Associate open

Qatar Biomedical Research Institute (QBRI), part of Hamad Bin Khalifa University (HBKU), is a national center of excellence in biomedical research. It aims to transform healthcare through
harnessing and converting the latest advances in science, medicine and technology into novel
discoveries that will lead to more effective treatments and preventive strategies for human diseases such as: diabetes, cancer and neurological disorders. The institute strives toward the development of novel diagnostic and therapeutic strategies to facilitate early diagnosis, treatment and management of these devastating diseases with the purpose of improving personalized medicine and healthcare.
QBRI has recently occupied state-of-the-art life sciences laboratories in a newly established research campus

Research Associates/Senior Research Associates
To fulfil its mission, QBRI is seeking a full-time research associate/senior research associate to work under the guidance of Dr Paul J Thornalley studying dysfunctional glucose metabolism and the role of methylglyoxal, glyoxalase 1 and its transcriptional regulation, and other metabolic dysfunction, in obesity and diabetes - including in collaboration with other groups within the institute and beyond. The research focuses on advanced understanding of mechanisms underlying cell dysfunction in obesity and diabetes - particularly associated with the development of insulin resistance and vascular complications of diabetes. Systems modelling will include: multi-compartment modelling of glucose metabolism; modeling of the Nrf2 oscillator and transcriptional signaling; and semi-automated image analysis from live cell microscopy. The appointment provides an opportunity to lead systems modelling within a pioneering team in diabetes and obesity research.

Key Responsibilities
  • To perform research in a multi-disciplinary, multi-skilled environment supporting cellular and molecular biology, proteomics, focused-metabolomics and systems biology studies.
  • To maintain good laboratory records, prepare standard operating procedures, interim reports,assist in the instruction of supporting research staff and preparation of manuscripts, and participate in the presentation and promotion of research findings.
  • To liaise with colleagues and collaborators for sample preparation and analysis, data extraction, systems modelling and reporting of outcomes.
  • To undertake literature searches and ensure the research program is kept current of new developments in the field.
  • To attend and contribute to regular research team meetings.
  • To demonstrate a commitment to personal continuing professional development.
  • To ensure compliance with health and safety in all aspects of work.

Requirements
  • A minimum of a PhD degree (or equivalent) in systems biology, mathematical biology biochemistry, cellular and molecular biology, proteomics, metabolomics or related subject appropriate for the post.
  • Demonstrated background knowledge, expertise and experience appropriate for the post.
  • An excellent record of success in the area(s) of previous research including publications (or papers in press) in peer reviewed journals
Additional Qualifications
  • Strong communication skills in English (both written and verbal) and excellent interpersonal skills are essential.
  • Interest and experience in metabolic dysfunction associated with obesity, diabetes and diabetic vascular complications is as advantage

How to Apply
- Please submit your complete application through the HBKU website
- https://hbku.edu.qa/en/qbri/research-associate

Deadline
- Complete applications will be reviewed and interviews will be arranged on a rolling basis until the position is filled Hamad Bin Khalifa University is an equal opportunity educator and employer. We are committed to maintaining culturally and academically diverse staff of the highest caliber.

Specimen papers:
1. Xue, M., Momiji, H., Rabbani, N., Barker, G., Shmygol, A., Bretschneider, T., Rand, D.A.
and Thornalley, P.J. (2015) Frequency modulated translocational oscillations of Nrf2
mediate the ARE cytoprotective transcriptional response. Antioxidants & Redo Signalling
Xue, M., Weickert, M.O., Qureshi, S., Kandala, N.-B., Anwar, A., Waldron, M., Shafie,
2. A., Messenger, D., Fowler, M., Jenkins, G., Rabbani, N. and Thornalley, P.J. (2016)
Improved glycemic control and vascular function in overweight and obese subjects by
glyoxalase 1 inducer formulation. Diabetes 65, 2282 - 2294.

posted 2019.01.28