A portal site for systems biology.

The »Magdeburg Center for Systems Biology« (MaCS) was formed in 2007 as an initiative of the University of Magdeburg and the Max Planck Institute for Dynamics of Complex Technical Systems. It is one of four research centres in Systems Biology that have been funded with financial support of the Federal Ministry of Education and Research of Germany (BMBF). Focus of our research is the development of new aproaches in systems biology and their application to the analysis and reconstruction of molecular networks for signal processing and regulation of cellular processes. As model organisms various pro- and eucaryotic species, e.g. cells of the human immune system, that respond to viral or bacterial infection provides as a basic for research. The goal is the establishment of new, broadly applicable concepts for modeling and systems analysis with reliability on different levels of molecular and functional complexity.

www.systembiologie-magdeburg.de
www.molecularinteractions.de

http://www.genego.com
GeneGo is a leading provider of data mining & analysis solutions in systems biology. Our data mining tools and databases help to capture and define the underlying biology behind different types of high-throughput experimental data and understand the effects of small molecule drug compounds in human tissues. We provide systems biology solutions for a full range of applications in life science research and drug development, from pre-clinical discovery and NCE applications to clinical trials, covering all aspects of biology and chemistry.

http://www.jhu.edu/apopel/
Department of Biomedical Engineering,
School of Medicine, Johns Hopkins University

www.sysbio.nl
The Netherlands Institute for Systems Biology (NISB) has been established early 2007.
NISB research will be characterised by the iterative cycle of experiment ----> predictive model --> quantitative prediction --> experimental verification --> improved model.
NISB will initially concentrate on the integrated functioning of metabolic, signal transduction and genetic networks in combination with systems that drive the generation of shape and force in cells. NISB will integrate expertise from biologists, chemists, physicists, and mathematicians available within Dutch research organisations.

http://www.vcu.edu/csbc/

http://www.biocant.pt/
Systems Biology Research Unit in a biotechnology research park. The Unit is devoted to pursuing fundamental and applied research in the Life Sciences from a systems biology standpoint.

www.imperial.ac.uk/cisbic
The Centre for Integrative Systems Biology at Imperial College (CISBIC) was established in 2005 with investment from the BBSRC. CISBIC will use state-of-the-art technologies to look at the interactions of a disease causing organism and its host on the level of molecules and individual cells. This will provide a platform for development of novel approaches to fight infectious diseases in humans, animals and plants. The centre will pioneer the development of new technologies in Systems Biology - a new approach to genomics which uses complex computational and mathematical analysis to advance on traditional methods.

http://www.systemsbiologyireland.org/

http://www.sysbio.org
Systems biology researchers at Pacific Northwest National Laboratory (PNNL) are focused on understanding gene and protein networks involved in individual cell signaling, communication between cells in communities, and cellular metabolic pathways. Our unique set of advanced instrumentation and technologies provide a strong technical
infrastructure for our systems biology research. We combine world-class, high-throughput proteomic tools; advanced sensors; precise analytical methods; enhanced imaging capabilities; and sophisticated computational tools to characterize and model cells responding to environmental changes, interrogating their surroundings, and communicating with other organisms in communities.

The Institute for Advanced Biosciences, established in the spring of 2001, is a pioneering research institute part of Keio University, Japan. Ongoing research activities focus on multiple aspects of systems biology and bioinformatics and aim, among other things, toward the complete description, understanding, and in silico modeling of the E. coli
bacterial cell and other living organisms.

The Manchester Centre for Integrative Systems Biology to be based in the Manchester Interdisicplinary Biocentre. Director Prof Douglas Kell.

Center for Cancer Systems Biology, Dana-Farber Cancer Institute is located in Boston, MA, USA. Dirctor, Prof. Marc Vidal

Hamilton Institute, Ireland

Centre for Computational and Systems Biology, University of Trento - Microsoft Research

Department of Systems Biology, Harvard Medical School

The Molecular Science Institute

Ottawa Institute of Systems Biology

The Systems Biology Institute: http://sbi.jp/
Host of this site:http://www.systems-biology.org/

The Warwick Systems Biology Centre is a new academic department at the University of Warwick.
http://www2.warwick.ac.uk/fac/sci/systemsbiology/

Institute for Systems Biology
http://www.systemsbiology.org/

Entelos
http://www.entelos.com/

Physiome Sciences
http://www.physiome.com

Gene Network Sciences
http://www.gnsbiotech.com/

Gene Networks, Inc.
http://www.gene-networks.com/

Beyond Genomics
http://www.beyondgenomics.com/

Systems Biology at Rostock University
The Systems Biology and Bioinformatics research group at Rostock University (O.Wolkenhauer) focusses on the development of systems- and control methodologies, using mathematical modelling and statistical data analysis applied to complex dynamical systems. Although these methodologies that can be applied in general, we concentrate on applications in molecular and cell biology.

Tyson Lab, Virginia Tech, USA
A research group located at the Virginia Polytechnic Institute and State University, specializing in computational models of cell cycle regulation.
The group also develops software for network modeling (JigCell), parameter estimation (PET), and bifurcation analysis (Oscill8).

Systems biology at PNNL is focused on understanding cellular networks-protein networks involved in cell signaling as well as networks of cells and their metabolic pathways. Advanced sensors, precise analytical methods, enhanced imaging, sophisticated computer modeling-these are combined to observe cells responding to environmental changes, interrogating their surroundings, and communicating with other organisms in communities.

MIT's Cell Decision Processes (CDP) Center is a multi-investigator cross-discplinary research program that takes a systems biology approach to the analysis of programmed cell death in human cells.CDP is a NIGMS Center of Excellence in Complex Biomedical Systems Research.

Ueda Lab, Center for Developmental Biology, RIKEN: a
systems biology lab of mammalian circadian clocks located in Kobe, Japan.
Headed by Prof. Hiroki R. Ueda.

Integrative Biochemistry laboratory, University of Barcelona is A laboratory of Systems Biology applied to Biomedicine and Biotechnology located in Barcelona, Spain.
Headed by Prof. Marta Cascante.

The group Computational Neurobiology develops quantitative models of neuronal signalling. It also maintains public services such as BioModels Database.

Kuroda lab, University of Tokyo: a systems biology lab of mammalian signal transduction located in Tokyo.
Headed by Prof. Shinya Kuroda.

Systems Biology Laboratory, Seoul National University
Lead by Kwang-Hyun Cho (Systems Biology), Sang-Mok Choo (Mathematics), Sung Hoon Jung (Computer Science), Seong-Jin Park (Electrical and Computer Engineering), and Hyeon-Woo Lee (Molecular Biology).

A research group located in Trento, Italy.
http://www.dit.unitn.it/~bioinfo

http://www.bioinfo.sfc.keio.ac.jp
A research group located in Kanagawa, Japan. This group has been developing a simulator E-Cell.

A research group located in Tokyo, and California Institute of Technology.
http://www.symbio.jst.go.jp
http://www.sbw-sbml.org