A portal site for systems biology.

PhD Student Position in Systems Biology - 2008
Systems Biology of Apoptotic Cell Death Signaling Networks

Applications are invited for a PhD studentship in Systems Biology in the Department of Physiology and Medical Physics/RCSI, Dublin, Ireland.

Candidates should have a background in computational biology, biophysics, or systems biology, and be experienced in numerical analysis/programming (e.g. C++, MATLAB, Mathematica or others). Good written and communication skills and a high level of motivation and commitment are required. The institute is located in the heart of Dublin city and offers an international and interdisciplinary working environment spanning the fields of systems biology, cancer and molecular biology, biophysics, and medical research.

Apoptotic cell death is regulated by complex signalling networks spanning several compartments within living cells. Impaired apoptosis can result in developmental disorders and cancer. In an industry collaboration with SIEMENS (Medical Division) the student will translate biological systems into novel computational models that allow the spatiotemporal and quantitative prediction of signalling events, and the identification of key regulatory factors or threshold mechanisms deciding on apoptotic cell death.

The applicant will work interactively with the experimentalists to discuss model validity and restrictions. Generated models will qualitatively and quantitatively be validated by experimentalists measuring the real time kinetics of key signalling events within living cells.

Applications should include CV, scans of relevant certificates and names and addresses of two referees and be sent (preferably by e-mail) to:

Dr. rer. nat. Markus Rehm
Lecturer in Physiology and Biophysics
Department of Physiology and Medical Physics
Royal College of Surgeons in Ireland
York Street Building Dublin 2 Ireland
email: mrehm at rcsi.ie Key

publications are available on request

posted 2008.03.25

Three research positions "Theoretical Systems Biology" at Dresden University of Technology, Germany

Applications from highly qualified candidates are invited for
* two full postdoctoral fellow positions for up to three years and
* one PhD position for three years in theoretical systems biology, mathematical biology and computational cell biology.

The goal is to discover, in close collaboration with experimental and medical partners, novel biophysical and biochemical mechanisms of information and material transport between subcellular compartments such as the plasma membrane, Golgi and nucleus as well as the spatio-temporal regulation of such mechanisms. The new members of our group will coordinate and conduct the above research and complement running projects which utilise a broad spectrum of theoretical tools with a focus on multi-scale modelling of spatio-temporal pattern formation.

The ideal postdoctoral candidate holds a Ph.D. in physics, applied mathematics or biology (or similar), has demonstrated expertise in systems biology, biophysics, nonlinear dynamics, stochastic methods or network analysis and has a strong interest in molecular cell biology. The Ph.D. candidate should possess a masters or diploma degree in physics or applied mathematics. A high level of motivation and commitment are required. Strong communication skills are important for the close collaborations with experimentalists and medical doctors.

The envisaged research will be conducted at the interdisciplinary Center for Information Services and High Performance Computing (ZIH), Dresden University of Technology, Germany, which hosts a department focusing on the mathematical modelling of biological systems (head: Andreas Deutsch). The Dresden campus is characterized by a vibrant international community of researchers that performs cross-disciplinary research at the highest level in state-of-the-art research centers. The city of Dresden and its surroundings are also rich in culture and impressive scenery. ZIH is an equal opportunity employer and strives to increase the number of women in research. We also encourage and invite applications from disabled individuals, who will be given priority if suitably qualified.

The positions are available from June 1, 2008. Deadline for applications
(by email, including contact details of two references): April 10, 2008.

Contact:
Andreas Deutsch
Center for Information Services and High Performance Computing (ZIH)
Dresden University of Technology, Germany
Tel.: +49 351 463-31943
Fax.: +49 351 463-38245
Email: andreas.deutsch at tu-dresden.de
WWW: http://theobio.mtbio.de/imc

posted 2008.03.25